当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Sustained release gastroretentive tablet of metformin hydrochloride based on poly (acrylic acid)-grafted-gellan.

Sustained release gastroretentive tablet of metformin hydrochloride based on poly (acrylic acid)-grafted-gellan.

Abstract：

:Development of a gastroretentive sustained release tablet of metformin based on poly (acrylic acid)-grafted-gellan (PAAc-g-GG) is the main purpose of this study. At first, PAAc-g-GG was synthesized by microwave-promoted free radical initiation method using cerric (IV) ammonium nitrate (CAN) as redox initiator and characterized by elemental analysis, FTIR, DSC-TGA, 13C NMR, biodegradation and viscosity study. The synthetic parameters were optimized by 23 full factorial design using Design Expert software. Acute oral toxicity and histological studies were also performed as per OECD guideline. Tablets were then prepared employing wet granulation method using PAAc-g-GG and evaluated for various physical characters, in vitro drug release, ex-vivo mucoadhesion and swelling. Compatibility between drug and excipients was checked by DSC and FTIR analysis. The F3 batch showed excellent mucoadhesion and sustained drug release over a period of 10h with dissolution similarity factor, f2=77.43. Kinetic modeling unveiled Case-1 Fickian diffusion based drug release mechanism.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Sarkar D,Nandi G,Changder A,Hudati P,Sarkar S,Ghosh LK

doi

10.1016/j.ijbiomac.2016.12.022

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

137-148

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(16)31459-3

journal_volume

96

pub_type

杂志文章

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