当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Synthesis, characterization and biomedical applications of a novel Schiff base on methyl acrylate-functionalized chitosan bearing p-nitrobenzaldehyde groups.

Synthesis, characterization and biomedical applications of a novel Schiff base on methyl acrylate-functionalized chitosan bearing p-nitrobenzaldehyde groups.

Abstract：

:Amino-functionalization has gained significant attention in the chemical modification of carbohydrate polymers due to their potential biomedical applications. Here, the preparation of innovative functionalized chitosan bearing amino-containing groups and equipped with p-nitrobenzaldehyde groups, resulting in an aminated chitosan bearing p-nitrobenzaldehyde (AmCs-pNBA) was described for the first time. The most important advantage of the chitosan functionalization was the success of its preparation at room temperature, avoiding the polymerization of methyl acrylate and instead it reacted entirely with chitosan. The resulting methyl acrylate chitosan was subsequently improved by the synthesized AmCs-pNBA Schiff base via the condensation of aldehyde groups with aminated chitosan. The structural characteristics of AmCs-pNBA were examined by FT-IR, XRD, TGA, SEM, and elemental analysis techniques. The antimicrobial, antioxidant, and anti-biofilm activities of AmCs-pNBA were assessed in vitro. The results revealed that this newly synthesized chitosan derivative displayed significant superior antibacterial, antioxidant, and anti-biofilm activities over the original chitosan. Besides, cytotoxicity and hemolytic analysis of the AmCs-pNBA were also evaluated. Results indicated that AmCs-pNBA support cell viability and proliferation without obvious hemolysis. These results show the potential of synthesizing the novel biomaterial candidate, AmCs-pNBA, with improved antibacterial, anti-biofilm, and antioxidant properties that may open a new perspective in biomedical applications.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Kenawy ER,Ali SS,Al-Etewy M,Sun J,Wu J,El-Zawawy N

doi

10.1016/j.ijbiomac.2018.11.005

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

833-843

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)33110-6

journal_volume

122

pub_type

杂志文章

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