当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Structural characterization and functional analysis of juvenile hormone diol kinase from the silkworm, Bombyx mori.

Structural characterization and functional analysis of juvenile hormone diol kinase from the silkworm, Bombyx mori.

Abstract：

:Juvenile hormone diol kinase (JHDK) is an important enzyme involved in the juvenile hormone metabolism pathway, which catalyzes the phosphorylation of juvenile hormone diol to form the polar metabolite JH diol phosphate. Here, we reported the first crystal structure of insect JHDK from Bombyx mori, BmJHDK-L2, determined at a resolution of 1.22 Å. The structure of BmJHDK-L2 mainly comprises of eight α-helical segments linked with loops, forming four helix-loop-helix motifs. In these four helix-loop-helix motifs with only one calcium ion bound in the first motif. Circular dichroism spectra indicated that BmJHDK-L2 has strong thermal stability, which is independent of the divalent cation. The structure of BmJHDK-L2 further allowed us to define an ATP-binding site using computational simulation and binding assays, providing a structural basis for development of inhibitor of JHDK. Moreover, the expression profile of BmJHDK-L2 indicated a predominant role in juvenile hormone metabolism in the Malpighian tubules of silkworm. Collectively, these findings expand our knowledge regarding the structural and biochemical features of insect JHDK proteins.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Xu H,Zhang Y,Zhang L,Wang Z,Guo P,Zhao P

doi

10.1016/j.ijbiomac.2020.11.138

subject

Has Abstract

pub_date

2021-01-15 00:00:00

pages

570-577

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(20)35065-0

journal_volume

167

pub_type

杂志文章

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