当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Myo-inositol hexasulphate and low molecular weight heparin binding to human acidic fibroblast growth factor: a calorimetric and FTIR study.

Myo-inositol hexasulphate and low molecular weight heparin binding to human acidic fibroblast growth factor: a calorimetric and FTIR study.

Abstract：

:The interaction of an amino-terminal-truncated 139 amino-acids form of human acidic fibroblast growth factor with myo-inositol hexasulphate and low molecular weight (3500 g mol(-1)) heparin has been studied by isothermal titration calorimetry, differential scanning calorimetry and Fourier transform infrared spectroscopy. A slightly higher affinity for the monosaccharide has been measured. The binding of the ligands causes an increase of 13--15 degrees C in the melting temperature of the free protein (45 degrees C). From measured enthalpy and heat capacity changes, calculations of changes in accessible surface areas have been made. These calculations, together with infrared spectroscopy data, indicate that a small conformational change is induced by the binding of both ligands. This conformational change would affect the tertiary structure, not the secondary one.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Guzmán-Casado M,Cardenete A,Giménez-Gallego G,Parody-Morreale A

doi

10.1016/s0141-8130(01)00131-3

keywords:

subject

Has Abstract

pub_date

2001-04-12 00:00:00

pages

305-13

issue

4

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(01)00131-3

journal_volume

28

pub_type

杂志文章

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