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Evaluation of polyurethane based on cellulose derivative-ketoprofen biosystem for implant biomedical devices.

Abstract：

:A polyether-urethane based on polytetrahydrofuran containing hydroxypropyl cellulose for biomedical applications was tested for its biocompatibility. Ketoprofen was incorporated (3% and 6%) in the polyurethane matrix as an anti-inflammatory drug. Dynamic vapour sorption method was employed for testing the water sorption/desorption behaviour of these materials with the determination of the surface isotherms, surface parameters and the kinetic curves of sorption/desorption processes. Cytotoxicity testing in vitro for quantifying cell proliferation was employed, and the results evidence noncytotoxicity for the studied polyurethane-drug systems. In vivo biocompatibility study was performed on 200 g weight male rats. It was found that after implantation of the polyether-urethane samples a reduced acute inflammation occurred, especially for polyurethane samples with added ketoprofen.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Macocinschi D,Filip D,Vlad S,Butnaru M,Knieling L

doi

10.1016/j.ijbiomac.2012.09.026

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

32-7

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(12)00380-7

journal_volume

52

pub_type

杂志文章

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