Abstract:
:Pseudomonas chlororaphis subsp. aurantiaca (DSM 19603) was grown on crude glycerol from biodiesel production to produce a medium-chain-length polyhydroxyalkanoate (mcl-PHA), composed of 3-hydroxydodecanoate (43 ± 1.8 mol%), 3-hydroxydecanoate (29 ± 3.1 mol%), 3-hydroxytetradecanoate (12 ± 0.4 mol%), 3-hydroxyoctanoate (10 ± 1.5 mol%) and 3-hydroxyhexanoate (6 ± 0.3 mol%). The biopolymer had an average molecular weight of 1.1 × 105 Da, with a polydispersity index of 1.5, and was semi-crystalline, as shown by its crystallinity index of 37 ± 0.2%. It had low melting (44 °C) and glass transition (-48 °C) temperatures, and was thermally stable up to 285 °C. The biopolymer films were elastic and translucid, were hydrophobic and presented relatively high permeability to oxygen and carbon dioxide. The films demonstrated to have good adhesion properties towards porcine skin and human skin. The tension (61.1 ± 20.6 kPa) and shear (12.7 ± 2.14 kPa) bond strength of the mcl-PHA for porcine skin suggest its potential as a biomaterial for the development of novel natural adhesives for wound closure or wound dressings.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Pereira JR,Araújo D,Marques AC,Neves LA,Grandfils C,Sevrin C,Alves VD,Fortunato E,Reis MAM,Freitas Fdoi
10.1016/j.ijbiomac.2018.09.064subject
Has Abstractpub_date
2019-02-01 00:00:00pages
1144-1151eissn
0141-8130issn
1879-0003pii
S0141-8130(18)33650-Xjournal_volume
122pub_type
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