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A structural study on the protection of glycation of superoxide dismutase by thymoquinone.

Abstract：

:Accumulation of advanced glycation end products (AGEs) in tissues and serum plays important roles in diabetes-associated complications. Therefore, the identification of antiglycating compounds is attracting considerable interest. In this study, the structural changes associated with the glycation of superoxide dismutase (SOD) and its protection by thymoquinone (TQ) have been investigated by biophysical techniques. Incubation of SOD with glucose, methylglyoxal (MG) or both at 37̊C resulted in progressive hyperchromicity at 280nm, intrinsic fluorescence quenching at 310nm, decrease in negative ellipticity at 208nm, AGE-specific fluorescence enhancement in the wavelength range 400-480nm and Thioflavin T (ThT) fluorescence enhancement at 480nm (fibrillar state enhancement). Therefore, glycation by glucose or MG induced both tertiary and secondary structural changes in SOD and formation of AGEs and fibrils. The changes were more and faster with MG than with glucose since MG is a stronger glycating agent than glucose. TQ offered protection against glucose or MG-induced glycation of SOD as observed by a reduction in the structural changes, formation of AGEs and fibrils. Thus, TQ can be used for reducing diabetic complications many of which are due to protein glycation.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Anwar S,Khan MA,Sadaf A,Younus H

doi

10.1016/j.ijbiomac.2014.06.003

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

476-81

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(14)00386-9

journal_volume

69

pub_type

杂志文章

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