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Glycation of α-synuclein amplifies the binding with glyceraldehyde-3-phosphate dehydrogenase.

Abstract：

:α-Synuclein was recently found to interact with moonlighting glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) involved in neurodegenerative diseases development. In the present work, we have analyzed influence of α-synuclein glycation on this interaction, because the literature data suggest relation between diabetes and Parkinson's disease. According to zeta potential measurement, glycation can shift the charge of α-synuclein to more negative values that was pronounced in case of modification by glyceraldehyde-3-phosphate. We selected carboxymethyl lysine as a typical advanced glycation end product and performed molecular dynamics simulations. The binding was found to be electrostatically driven and was significantly amplified after α-synuclein glycation because of increase the number of acidic residues. Since the main binding site was located in the anion-binding groove, which comprises the active site of GAPDH, enhanced binding of α-synuclein can result in GAPDH inactivation. This hypothesis was proven experimentally. Glycation of α-synuclein resulted in increase of GAPDH inactivation, and this effect was more pronounced in case of modification by glyceraldehyde-3-phosphate. The obtained results can reflect the probable relations between protein glycation and neurodegenerative diseases.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Semenyuk P,Barinova K,Muronetz V

doi

10.1016/j.ijbiomac.2019.01.064

subject

Has Abstract

pub_date

2019-04-15 00:00:00

pages

278-285

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)36292-5

journal_volume

127

pub_type

杂志文章

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