Abstract：
:3D porous composites based on blends of chitosan, collagen and hyaluronic acid were obtained through the lyophilization process. Mechanical properties, swelling behavior and thermal stability of the blends were studied. Moreover, SEM images were taken and the structure of the blends was studied. Biological properties of the materials obtained were investigated by analyzing of proliferation rate of fibroblast cells incubated with biomaterial extract using MTT assay (3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide). The results showed that the properties of 3D composites based on the blends of chitosan and collagen were altered after the addition 1%, 2% and 5% of hyaluronic acid. Mechanical properties and thermal stability of chitosan/collagen blends were improved in the presence of hyaluronic acid in the composite. New 3D materials based on the blends of chitosan, collagen and hyaluronic acid were non-toxic and did not significantly affect cell morphology.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Sionkowska A,Kaczmarek B,Lewandowska K,Grabska S,Pokrywczyńska M,Kloskowski T,Drewa Tdoi
10.1016/j.ijbiomac.2016.04.085subject
Has Abstractpub_date
2016-08-01 00:00:00pages
442-8eissn
0141-8130issn
1879-0003pii
S0141-8130(16)30402-0journal_volume
89pub_type
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