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Thermo-sensitive chitosan based semi-IPN hydrogels for high loading and sustained release of anionic drugs.

Abstract：

:Thermo-sensitive poly(N-isopropyl acrylamide-co-vinyl pyrrolidone)/chitosan [P(NIPAM-co-NVP)/CS] semi-IPN hydrogels with improved loading capacity and sustained release for anionic drugs NAP were prepared by free-radical polymerization. The LCST of hydrogels was adjusted to the vicinity of body temperature by introducing hydrophilic NVP. The presence of CS in semi-IPN networks improves the swelling behavior and provides a high affinity for anionic drug NAP due to the strong interactions between NAP molecules and CS chains. Release of NAP was suppressed at pH 2.2 and 5.0 and accelerated at pH 7.4 due to the deprotonation of amino groups in CS. Increasing temperature above LCST, hydrogels showed a continuous release of NAP without burst diffusion due to the shrinkage of PNIPAM restraining the drug release.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Li G,Guo L,Chang X,Yang M

doi

10.1016/j.ijbiomac.2012.02.013

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

899-904

issue

4

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(12)00067-0

journal_volume

50

pub_type

杂志文章

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