Abstract:
:In recent days, the green synthesized nanomagnetic biocomposites have been evolved with tremendous potential as the future catalysts. This has encouraged us to design and synthesis of a novel Au NPs immobilized pectin modified magnetic nanoparticles (Fe3O4/Pectin/Au). It was meticulously characterized using advanced analytical techniques like FT-IR, FESEM, TEM, EDX, XPS, VSM, XRD and ICP-OES. We investigated the chemical applications of the material in the catalytic reduction of nitroarenes using N2H4.H2O as the reducing agent in the EtOH/H2O solvent without any promoters or ligands. Due to strong paramagnetism, the catalyst was easily recovered and reused in 11 cycles without considerable leaching or loss in reactivity. The green protocol involves several advantages like mild conditions, easy workup, high yields, and reusability of the catalyst. Furthermore, the desired nanocomposite was employed in biological studies like anti-oxidant assay by DPPH radical scavenging test. Subsequently, on exhibiting a good IC50 value in the DPPH assay, we extended the bio-application of the Fe3O4/Pectin/Au in the anticancer study of adenocarcinoma cells of human lungs using three cancer cell lines, PC-14, LC-2/ad and HLC-1 and a normal cell line HUVEC. The best result was accomplished in PC-14 cell lines with the lowest IC50 values.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Li Y,Li N,Jiang W,Ma G,Zangeneh MMdoi
10.1016/j.ijbiomac.2020.09.102subject
Has Abstractpub_date
2020-11-15 00:00:00pages
2162-2171eissn
0141-8130issn
1879-0003pii
S0141-8130(20)34461-5journal_volume
163pub_type
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