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Effect of hyaluronic acid molecular weight on the morphology of quantum dot-hyaluronic acid conjugates.

Abstract：

:The morphological analysis of novel quantum dot-hyaluronic acid (QDot-HA) conjugates was carried out with a transmission electron microscope (TEM). Adipic acid dihydrazide-modified HA (HA-ADH) was synthesized and conjugated to quantum dots (QDots) having carboxyl terminal ligands which were activated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysulfosuccinimide (sulfo-NHS). HA molecules with a molecular weight (MW) of 20K, 234 K and 3000 K were used to investigate the effect of MW on the morphology of QDot-HA conjugates. The TEM micrographs of QDot-HA conjugates showed branched and multi-layered chain type morphology formed by inter- and intra-molecular conjugation of QDots to HA molecules. The size of QDot-HA conjugate increased with the MW of HA. QDot-HA conjugate could be successfully used for real-time bio-imaging of HA derivatives in nude mice. The novel QDot-HA conjugate will be further used to investigate the biological roles of HA with a different MW in the body.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Kim J,Park K,Hahn SK

doi

10.1016/j.ijbiomac.2007.09.002

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

41-5

issue

1

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(07)00216-4

journal_volume

42

pub_type

杂志文章

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