Abstract：
:A prospective completely randomized experimental study was conducted using 48 animals to evaluate the physiometabolic effects of Agave salmiana fructans as a dietary supplement in healthy Wistar rats. Five fructans concentrations from 5 to 20% (w/w) and one control were used in the rats' diet and were divided into six groups (n=8 rats/group). The treatments were carried out for 35days, during which glucose, cholesterol, triglycerides, body-weight gain, food intake, fecal excretion, organ weights, renal and hepatic functions and a histological analysis of the cecum were evaluated. Glucose, cholesterol, triglycerides, renal and hepatic functions were not significantly affected by any treatment. Body-weight gain and food intake were lower in the rat groups fed fructans than in the control group. Increased fecal excretion (p<0.05) was observed only in animals fed 12.5 and 20% fructans. Mice supplemented with fructans exhibited increased weight and length (p<0.05) in the cecum and colon. A histological analysis of the cecum showed cellular proliferation with a dose of 12.5% and membrane lysis at doses of 15 and 20%. In conclusion, the inclusion of 12.5% of Agave salmiana fructans in the animals' diets exerts beneficial physiometabolic effects after the seventh treatment day.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Castillo Andrade AI,Rivera Bautista C,Godínez Hernández C,Ruiz Cabrera MA,Fuentes Ahumada C,García Chávez E,Grajales Lagunes Adoi
10.1016/j.ijbiomac.2017.11.043subject
Has Abstractpub_date
2018-03-01 00:00:00pages
1300-1309eissn
0141-8130issn
1879-0003pii
S0141-8130(17)33509-2journal_volume
108pub_type
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journal_title：International journal of biological macromolecules
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