Synthesis of a dextran based thermo-sensitive drug delivery system by gamma irradiation.

Abstract:

:Gamma radiation was used as the initiator/crosslinker agent for the synthesis of thermo-sensitive hydrogel networks, under the form of membranes, using dextran and N-isopropylacrylamide. The prepared membranes were loaded with Ondansetron™, a potent antiemetic drug and tested as drug delivery systems. The characterization of the materials was accomplished by: Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectroscopy, elemental analysis, lower critical solution temperature (LCST) determination, swelling behaviour evaluation, determination of surface energy by contact angle measurement and drug delivery kinetics studies. Also, the influence of irradiation time and temperature on the materials properties was evaluated.

journal_name

Int J Biol Macromol

authors

Almeida JF,Ferreira P,Alves P,Lopes A,Gil MH

doi

10.1016/j.ijbiomac.2013.07.002

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

150-5

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(13)00385-1

journal_volume

61

pub_type

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