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Effects of β-glucans from Coriolus versicolor on macrophage phagocytosis are related to the Akt and CK2/Ikaros.

Abstract：

:Coriolus versicolor has been known to be an immune stimulator effects. For further understanding of the phagocytic activity and the intracellular mechanisms of β-glucan from C. versicolor (CVG), we examined the phagocytic activity, phosphorylation of Akt and CK2, nucleus translocation of p65 and Ikaros activity in β-glucan-treated macrophages using RT-PCR, western blotting, and IP assay. The role of Ikaros in regulating phagocytic effects of CVG was also determined using Ikaros dominant negative isoform cells. This study suggests that CK2/Ikaros are positive regulators and novel signaling pathway involved in phagocytosis and contributes to elucidating the mechanism underlying phagocytic activity induced by β-glucan.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Kang SC,Koo HJ,Park S,Lim JD,Kim YJ,Kim T,Namkoong S,Jang KH,Pyo S,Jang SA,Sohn EH

doi

10.1016/j.ijbiomac.2013.03.017

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

9-16

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(13)00100-1

journal_volume

57

pub_type

杂志文章

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