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Modulating cationicity of chitosan hydrogel to prevent hypertrophic scar formation during wound healing.

Abstract：

:It is of great clinical significance to design wound dressing materials with combined excellent wound healing properties and superior capability to suppress hypertrophic scar formation. This study aimed to examine if and how the cationicity of chitosan would affect the hypertrophic scar-related outcomes, through preparing carboxymethyl chitosan hydrogels with different genipin concentrations (2.5%, 5%, 10% and 15%, respectively). An optimum window of chitosan cationicity (5% in our case) demonstrated potential to mitigate hypertrophic scar in wound healing by suppressing the expression of a-smooth muscle actin (a-SMA) and promoting secretion of type I matrix metalloproteinases (MMP-1). In vivo, the CMCS-5% hydrogel again showed smaller, thinner and smoother wound appearance. Moreover, the CMCS-5% sample with additional incorporation of 2% (V/V) Aloe vera gel exhibited further improved performance in scar inhibition. Overall, such findings might have important implications in chitosan-based wound dressing design for high-quality wound repair and effective scar inhibition.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Zhang N,Gao T,Wang Y,Liu J,Zhang J,Yao R,Wu F

doi

10.1016/j.ijbiomac.2020.03.161

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

835-843

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(20)32065-1

journal_volume

154

pub_type

杂志文章

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