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Evaluation of mucoadhesive potential of gum cordia, an anionic polysaccharide.

Abstract：

:The study involves mucoadhesive evaluation by formulating buccal discs using fluconazole as the model drug. The effect of compression pressure and gum cordia/lactose ratio on the ex vivo bioadhesion time and in vitro release of fluconazole was optimized using central composite experimental design. It was observed that the response ex vivo bioadhesion time was affected significantly by the proportion of gum cordia in the buccal discs while the in vitro release of fluconazole from the buccal discs was influenced significantly by the compression pressure. The optimized batch of buccal discs comprised of gum cordia/lactose - 0.66, fluconazole - 20 mg and was compressed at the pressure of 6600 kg. Further, it provided the ex vivo bioadhesion of 22 h and in vitro release of 80% in 24h. In conclusion, gum cordia is a promising bucoadhesive polymer.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Ahuja M,Kumar S,Kumar A

doi

10.1016/j.ijbiomac.2012.12.038

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

109-12

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(12)00523-5

journal_volume

55

pub_type

杂志文章

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