当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Overexpressed LRIG3 gene ameliorates prostate cancer through suppression of cell invasion and migration.

Overexpressed LRIG3 gene ameliorates prostate cancer through suppression of cell invasion and migration.

Abstract：

:Prostate cancer (PC) is one of the most common human malignancies, which has been steadily rising among males in many countries. The leucine-rich repeats and immunoglobulin-like domains (LRIG) genes were applied in the prognosis of different types of cancers, including PC. In that case, this study is supposed to investigate the effects of LRIG3 on PC cells. LRIG3 was overexpressed or under-expressed by the rAd and siRNA to determine the effect of LRIG3 on PC and explore the possible mechanism. The mRNA and protein levels of LRIG3 were tested by RT-qPCR and western blot analysis. Cell apoptosis, viability, migration and invasion were measured using MTT assay, flow cytometry and Transwell assay respectively. We observed that LRIG3 mRNA and protein levels were decreased in PC-3 cells. PC-3 cells treated with rAd-LRIG3 exhibited significantly increased cell apoptosis while inhibited viability, adhesion, migration and invasion. However, C4-2 cells treated with siRNA-LRIG3 showed reciprocal results. In conclusion, these data of the current study indicated that overexpressed LRIG3 gene expression might inhibit the viability, adhesion, invasion and migration and promote the apoptosis of PC cells. rAd-mediated LRIG3 may facilitate a novel aspect of the treatment of patients suffering from with PC.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Chen Y,Wang Q,Wang M,Li M

doi

10.1016/j.ijbiomac.2018.11.028

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

1-9

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)32968-4

journal_volume

124

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • The transition of polymers into a network of polymers alters per se the water activity.

    abstract：:We have found that polyacrylamide gels cross-linked with bisacrylamide induce a larger macromolecular osmotic pressure than the non cross-linked gels. This means also that in the cross-linked gels hydration water is held more tightly to the polymer, i.e., more work is needed to remove water, than in the non cross-link...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2004.11.002

    authors： Trombetta G,Di Bona C,Grazi E

    更新日期：2005-03-01 00:00:00

  • Brönsted acidic ionic liquid based ultrasound-microwave synergistic extraction of pectin from pomelo peels.

    abstract：:3-Methyl-1-(4-sulfonylbutyl) imidazolium hydrogensulfate, [HO3S(CH2)4mim]HSO4, was applied as an extractant in an ultrasound-microwave synergistic extraction approach to substitute conventional solvent for the extraction of pectin from the albedo part of pomelo peels. The analysis of variance (ANOVA) test and response...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.10.028

    authors： Liu Z,Qiao L,Yang F,Gu H,Yang L

    更新日期：2017-01-01 00:00:00

  • Light-induced phosphorylation of crystallins in the retinal pigment epithelium.

    abstract：:Protein phosphorylations have essential regulatory roles in visual signaling. Previously, we found that phosphorylation of several proteins in the retina and retinal pigment epithelium (RPE) is involved in anti-apoptotic signaling under oxidative stress conditions, including light exposure. In this study, we used a ph...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2010.11.006

    authors： Lee H,Chung H,Lee SH,Jahng WJ

    更新日期：2011-01-01 00:00:00

  • Complexation of rice starch/flour and maize oil through heat moisture treatment: Structural, in vitro digestion and physicochemical properties.

    abstract：:This study investigated structural, in vitro digestion and physicochemical properties of normal rice starch (NRS)/flour (NRF) complexed with maize oil (MO) through heat-moisture treatment (HMT). The NRS-/NRF-MO complex displayed an increased pasting temperature and a decreased peak viscosity. After HMT, less ordered M...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.01.105

    authors： Chen X,He X,Fu X,Zhang B,Huang Q

    更新日期：2017-05-01 00:00:00

  • Boron stabilizes peroxide mediated changes in the structure of heme proteins.

    abstract：:Boron is reported in this study to stabilize the structure of heme proteins exposed to peroxides. The oxidized heme protein (15 microM) was treated with H(2)O(2) (10mM) in 1M glycine-NaOH buffer (pH 9.2) at 25 degrees C in absence/presence of boron, and characterized by visible absorption spectroscopy, gel exclusion c...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2010.05.013

    authors： Ali S,Farooqi H,Prasad R,Naime M,Routray I,Yadav S,Ahmad F

    更新日期：2010-08-01 00:00:00

  • Electrospinning of multifunctional cellulose acetate membrane and its adsorption properties for ionic dyes.

    abstract：:Electrospinning of cellulose acetate with appropriated solvent system is the most straightforward method for fabricating micro- and nanofibers. To simultaneously and effectively remove both cationic and anionic dyes, a novel cost-effective multifunctional cellulose acetate (CA) fibers membrane was prepared by electros...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.249

    authors： Chen W,Ma H,Xing B

    更新日期：2020-05-03 00:00:00

  • Comparative study on citric acid modified instant starches (alcoholic alkaline treated) isolated from white sorghum and corn grains.

    abstract：:This study investigated the impact of citric acid modification combined with alcoholic-alkaline treatment on physicochemical, textural and rheological properties of sorghum and corn starches. Both starches were modified with citric acid (CA) using concentrations (20 and 40%) w/w and were named as SCA and CCA, respecti...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.10.143

    authors： Zehra N,Mohsin Ali T,Hasnain A

    更新日期：2020-05-01 00:00:00

  • Molecular characterization, constitutive expression and GTP binding mechanism of Cirrhinus mrigala (Hamilton, 1822) Myxovirus resistance (Mx) protein.

    abstract：:Myxovirus resistance (Mx) proteins represents the subclass of the dynamin superfamily of large Guanosine triphosphates (GTPases), play esential role in intracellular vesicle trafficking, endocytosis, organelle homeostasis and mitochondria distribution. These proteins are key players of the vertebrate immune system, in...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.06.161

    authors： Roy P,Rout AK,Maharana J,Sahoo DR,Panda SP,Pal A,Nayak KK,Behera BK,Das BK

    更新日期：2019-09-01 00:00:00

  • Effect of O-glycosylation on amyloid fibril formation of the variable domain in the Vλ6 light chain mutant Wil.

    abstract：:Glycosylation is one of the major post-translational modifications in eukaryotic cells and has been reported to affect the amyloid fibril formation in several amyloidogenic proteins and peptides. In this study, we expressed a Vλ6 light chain mutant, Wil, which is an amyloidogenic mutant in AL amyloidosis, by the yeast...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.10.194

    authors： Abe Y,Shibata H,Oyama K,Ueda T

    更新日期：2021-01-01 00:00:00

  • Microencapsulation of lectin anti-cancer agent and controlled release by alginate beads, biosafety approach.

    abstract：:Hepatocellular carcinoma (HCC) is considered as one of the most aggressive cancer worldwide. In Egypt, the prevalence of HCC is increasing during last years. Recently, drug-loaded microparticles were used to improve the efficiency of various medical treatments. This study is designed to evaluate the anticancer potenti...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.05.031

    authors： El-Aassar MR,Hafez EE,El-Deeb NM,Fouda MM

    更新日期：2014-08-01 00:00:00

  • Evaluation of microwave assisted grafted sago starch as controlled release polymeric carrier.

    abstract：:In the present investigation an attempt has been made to develop a new co-polymeric material for controlled release tablet formulations. The acrylamide grafting was successfully performed on the backbone of sago starch. The modified starch was tested for acute toxicity and drug-excipient compatibility study. The graft...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.05.008

    authors： Singh AV,Nath LK

    更新日期：2013-09-01 00:00:00

  • N-terminal residues are crucial for quaternary structure and active site conformation for the phosphoserine aminotransferase from enteric human parasite E. histolytica.

    abstract：:Phosphoserine aminotransferase (PSAT) is a pyridoxal-5'phosphate (PLP)-dependent enzyme that catalyzes the second reversible step in the phosphoserine biosynthetic pathway producing serine. The crystal structure of E. histolytica PSAT (EhPSAT) complexed with PLP was elucidated at 3.0 Å resolution and the structures of...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.04.027

    authors： Singh RK,Tomar P,Dharavath S,Kumar S,Gourinath S

    更新日期：2019-07-01 00:00:00

  • Polysaccharides from loquat (Eriobotrya japonica) leaves: Impacts of extraction methods on their physicochemical characteristics and biological activities.

    abstract：:Impacts of hot water extraction (HWE), pressurized water extraction (PWE), high-speed shearing homogenization extraction, microwave assisted extraction (MAE), ultrasound assisted extraction (UAE), ultrasound assisted enzymatic extraction, and ultrasound-microwave assisted extraction (UMAE) on physicochemical character...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.12.273

    authors： Fu Y,Li F,Ding Y,Li HY,Xiang XR,Ye Q,Zhang J,Zhao L,Qin W,Gan RY,Wu DT

    更新日期：2020-03-01 00:00:00

  • From cashew byproducts to biodegradable active materials: Bacterial cellulose-lignin-cellulose nanocrystal nanocomposite films.

    abstract：:While the cashew culture is focused on processing and commercialization of cashew nuts, the pseudofruit (cashew apples) - highly perishable and of limited acceptance - are mostly wasted. The cashew tree pruning fiber (CTPF) is another interesting cashew byproduct. In this study, films have been made from bacterial cel...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.07.269

    authors： Sá NMSM,Mattos ALA,Silva LMA,Brito ES,Rosa MF,Azeredo HMC

    更新日期：2020-10-15 00:00:00

  • Surface characteristics of polyurethane elastomers based on chitin/1,4-butane diol blends.

    abstract：:Biodegradable polyurethane elastomers with tunable hydrophobicity were synthesized by step-growth polymerization techniques using poly(epsilon-caprolactone) (PCL) and 4,4'-diphenylmethane diisocyanate (MDI). The prepolymer was extended with different mass ratios of chitin and 1,4-butane diol (BDO). The effect of chiti...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2008.12.004

    authors： Zia KM,Barikani M,Zuber M,Bhatti IA,Barmar M

    更新日期：2009-03-01 00:00:00

  • Molecular mechanisms and genetics of hyaluronan biosynthesis.

    abstract：:Hyaluronan is an extremely important polysaccharide from both the biological and commercial points of view. This review summarizes the present state of the art concerning the polymer and our understanding of the molecular mechanisms of its synthesis with emphasis on the implications of this understanding for polysacch...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/0141-8130(94)90056-6

    authors： O'Regan M,Martini I,Crescenzi F,De Luca C,Lansing M

    更新日期：1994-12-01 00:00:00

  • Structural characterisation and immunomodulatory activity of a neutral polysaccharide from Sambucus adnata Wall.

    abstract：:A neutral polysaccharide, SPW-2, was purified from the leaves of Sambucus adnata Wall. using water extraction and alcohol precipitation, Sevage deproteination, ion exchange chromatography and gel filtration chromatography. This molecule had an average molecular weight of 7040 Da and was composed of arabinose, xylose, ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.11.021

    authors： Yuan L,Zhong ZC,Liu Y

    更新日期：2020-07-01 00:00:00

  • Development of albumin-based nanoparticles for the delivery of abacavir.

    abstract：:The study was designed to prepare and evaluate albumin nanoparticles containing antiviral drug abacavir sulphate. Various batches of albumin nanoparticles containing abacavir sulphate were prepared by desolvation method. The abacavir loaded particles were characterized for their yield, percentage of drug loading, surf...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.09.015

    authors： Wilson B,Paladugu L,Priyadarshini SR,Jenita JJ

    更新日期：2015-11-01 00:00:00

  • Enhanced antibacterial activity of PEO-chitosan nanofibers with potential application in burn infection management.

    abstract：:Chitosan (CS) is a well-known biological macromolecule having numerous applications due to its exceptional properties especially in the form of nanofibers. The antibacterial activity is compromised when co-polymers are added to electrospun CS but, the reproducibility can be enhanced which is key to commercialization. ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.06.022

    authors： Abid S,Hussain T,Nazir A,Zahir A,Ramakrishna S,Hameed M,Khenoussi N

    更新日期：2019-08-15 00:00:00

  • 4- Substituted sampangine derivatives: Novel acetylcholinesterase and β-myloid aggregation inhibitors.

    abstract：:A series of 4- substituted sampangine derivatives (4-aminoalkylaminosampangine Ar-NH(CH2)nNR1R2) has been designed, synthesized, and tested for their ability to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and β-myloid (Aβ) aggregation. The synthetic compounds exhibited high AChE inhibitory activi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.10.157

    authors： Chen KL,Gan L,Wu ZH,Qin JF,Liao WX,Tang H

    更新日期：2018-02-01 00:00:00

  • Purification and partial characterization of a new lectin from Parkia panurensis Benth. ex H.C. Hopkins seeds (Leguminosae family; Mimosoideae subfamily) and evaluation of its biological effects.

    abstract：:Lectins are proteins that have as one of their main characteristics recognizing and reversibly binding to carbohydrates. In this work, it was possible to purify and characterize a lectin from Parkia panurensis (Leguminosae family; Mimosoideae subfamily) seeds by a combination of the techniques: protein precipitation, ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.10.102

    authors： Cavada BS,Bari AU,Pinto-Junior VR,Lossio CF,Silva MTL,Souza LAG,Oliveira MV,Souza-Filho CHD,Correia SEG,Vital APMS,Lima LD,Osterne VJS,Nascimento KS

    更新日期：2020-02-15 00:00:00

  • Effect of polyamines on the structure, thermal stability and 2,2,2-trifluoroethanol-induced aggregation of alpha-chymotrypsin.

    abstract：:Naturally occurring polyamines are known to interact with a variety of biomolecules and critically involve in some important physiological processes. They have also been shown to influence protein aggregation in vitro in some cases. The aim of the present study was to investigate how polyamines may influence the struc...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2007.07.018

    authors： Rezaei-Ghaleh N,Ebrahim-Habibi A,Moosavi-Movahedi AA,Nemat-Gorgani M

    更新日期：2007-12-01 00:00:00

  • Identification of Inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses.

    abstract：:Inonotus obliquus polysaccharides (IOPs) are a potential drug for the prevention and treatment of cancer, cardiopathy, diabetes, AIDs, pancreatitis and other diseases. In this study, we found that IOP can act as a broad-spectrum antiviral drug against feline viruses in the in vitro experiment. Using cell models of fel...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.11.054

    authors： Tian J,Hu X,Liu D,Wu H,Qu L

    更新日期：2017-02-01 00:00:00

  • Use of guar gum, gum arabic, pectin, beta-glucan and inulin for microencapsulation of anthocyanins from chokeberry.

    abstract：:The aim of this study was to use micro-encapsulation technology to create microcapsules containing anthocyanins from chokeberry with guar gum, gum arabic, pectin, β-glucan and inulin as wall material. Aqueous extracts from chokeberry fruit were enclosed and spray dried using maltodextrin as a coating material with the...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.02.073

    authors： Pieczykolan E,Kurek MA

    更新日期：2019-05-15 00:00:00

  • Graphene oxide derivatives with variable alkyl chain length and terminal functional groups as supports for stabilization of cytochrome c.

    abstract：:In this study we report the ability of reduced and non-reduced graphene oxide-based nanomaterials (GONs), modified with variable alkyl chain length and terminal functional groups, to act as effective scaffolds for the immobilization of cytochrome c (cyt c) using different immobilization procedures. The GONs/cyt c conj...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.12.023

    authors： Patila M,Pavlidis IV,Kouloumpis A,Dimos K,Spyrou K,Katapodis P,Gournis D,Stamatis H

    更新日期：2016-03-01 00:00:00

  • Novel hydrogels based on yeast chitin-glucan complex: Characterization and safety assessment.

    abstract：:Chitin-glucan complex (CGC) was used for the first time for the preparation of hydrogels. Alkali solvent systems, NaOH and KOH solutions, either at 1 or 5 mol/L, were used for CGC dissolution using a freeze-thaw procedure (freezing at -20 °C and thawing at room temperature; four cycles). The CGC solutions thus obtaine...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.11.141

    authors： Araújo D,Alves VD,Lima SAC,Reis S,Freitas F,Reis MAM

    更新日期：2020-08-01 00:00:00

  • Structure of spherical viruses.

    abstract：:This review summarizes some of the results obtained from the crystal structure determination of viruses. The structural similarities of viral coat proteins is discussed, as well as some structural results related to the regulation of viral disassembly. ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/0141-8130(91)90026-q

    authors： Liljas L

    更新日期：1991-10-01 00:00:00

  • Low molecular weight chitosan nanoparticles for CpG oligodeoxynucleotides delivery: Impact of molecular weight, degree of deacetylation, and mannosylation on intracellular uptake and cytokine induction.

    abstract：:Although synthetic CpG oligodeoxynucleotides (ODNs) have shown substantial potential as immunotherapeutic agents, their effective intracellular delivery remains challenging. In this work, nanoparticles prepared from low-molecular weight (LMW) chitosans were investigated as CpG ODN delivery systems. Chitosan samples wi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.05.048

    authors： Babii O,Wang Z,Liu G,Martinez EC,van Drunen Littel-van den Hurk S,Chen L

    更新日期：2020-09-15 00:00:00

  • Alginate-based hydrogels for cancer therapy and research.

    abstract：:Cancer is a major health issue concerning to all of us. Current treatment options are still limited due to not-selective action. Encapsulation is contemplated as an innovative approach to address systemic toxicity and tumor resistance caused by traditional therapies, while increasing encapsulated compounds bioavailabi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2020.12.161

    authors： Reig-Vano B,Tylkowski B,Montané X,Giamberini M

    更新日期：2021-02-15 00:00:00

  • Psyllium arabinoxylan: carboxymethylation, characterization and evaluation for nanoparticulate drug delivery.

    abstract：:The objective of present investigation was to optimize the interaction between carboxymethylated psyllium arabinoxylan and chitosan to prepare polyelectrolyte naoparticles for drug delivery applications. Arabinoxylan extracted from psyllium was carboxymethylated by reacting with monochloroacetic acid under alkaline co...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.08.051

    authors： Bhatia M,Ahuja M

    更新日期：2015-01-01 00:00:00