当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Antitumor evaluation of carboxymethyl chitosan based norcantharidin conjugates against gastric cancer as novel polymer therapeutics.

Antitumor evaluation of carboxymethyl chitosan based norcantharidin conjugates against gastric cancer as novel polymer therapeutics.

Abstract：

:Novel polymer-drug conjugates (CNC) were prepared from carboxymethyl chitosan (CMCS) and norcantharidin (NCTD) via amidation reaction and characterized by FTIR and 1H NMR spectroscopy. The aim of this study was to elucidate the antitumor efficacy of CNC on gastric cancer and the possible underlying mechanisms. The CNC conjugates possessed significant inhibitory effects on the proliferation of SGC-7901 cells and suppressed the migration as well as tube formation of HUVECs. Besides, Hoechst 33258 staining and Annexin V-FITC/PI detection suggested that the conjugates were more effective in triggering apoptosis of SGC-7901 cells compared with free NCTD. Moreover, CNC remarkably reduced systemic toxicity and enhanced the antitumor efficacy in vivo with a tumor suppression rate of 59.57% against SGC-7901 gastric tumor in BALB/c nude mice. Further investigation about the underlying mechanisms indicated that CNC could upregulate expressions of TNF-α and Bax, and downregulate expressions of VEGF, Bcl-2, MMP-2 and MMP-9, thereby inhibiting tumor metastasis and inducing apoptosis in vivo. Overall, our results demonstrated that CNC might be a promising and feasible polymer therapeutics for gastrointestinal tumor therapy.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Chi J,Jiang Z,Qiao J,Zhang W,Peng Y,Liu W,Han B

doi

10.1016/j.ijbiomac.2019.05.216

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

1-12

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)30081-9

journal_volume

136

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Multifunctional alginate-based hydrogel with reversible crosslinking for controlled therapeutics delivery.

    abstract：:Glycan-based alginate hydrogels have great potential in creating new vehicles with responsive behavior and tunable properties for biomedicine. However, precise control and tunability in properties present major barrier for clinical translation of these materials. Here, we report the synthesis of pH responsive anthrace...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.02.042

    authors： Batool SR,Nazeer MA,Ekinci D,Sahin A,Kizilel S

    更新日期：2020-05-01 00:00:00

  • Rapid self-association of highly amyloidogenic H-fragments of insulin: Experiment and molecular dynamics simulations.

    abstract：:The so-called 'H-fragment' of insulin is an extremely amyloidogenic double chain peptide consisting of the N-terminal parts of A-chain and B-chain linked by a disulfide bond between Cys-7A and Cys-7B. Here, we conduct a detailed investigation of the self-association behavior of H-fragment monomers into amyloid-like fi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.02.153

    authors： Dec R,Koliński M,Kouza M,Dzwolak W

    更新日期：2020-05-01 00:00:00

  • Structural alteration of low pH, low temperature induced protonated form of DNA to the canonical form by the benzophenanthridine alkaloid nitidine: Spectroscopic exploration.

    abstract：:Polymorphism of DNA plays a very important part of research relating to the drug-DNA interactions. Here main focus of our investigation is to monitor the interaction of the benzophenanthridine plant alkaloid, nitidine (NIT) with two different forms of DNA i.e. B-DNA and protonated form of DNA maintaining proper temper...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.08.031

    authors： Haque L,Bhuiya S,Giri I,Chowdhury S,Das S

    更新日期：2018-11-01 00:00:00

  • Purification, biochemical and biophysical characterization of lysosomal β-D-glucuronidase from an edible freshwater mussel, Lamellidens corrianus.

    abstract：:A lysosomal glycosidase, β-glucuronidase, has been purified to homogeneity, from the soluble extracts of a freshwater mussel, L. corrianus, by a series of chromatography techniques involving phenyl-Sepharose, ion exchange, affinity and gel filtration chromatography. In native PAGE, β-glucuronidase resolved into a sing...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.02.190

    authors： Konada RSR,Venugopal A,Nadimpalli SK

    更新日期：2020-06-01 00:00:00

  • Development of inter-polymeric complex of anionic polysaccharides, alginate/k-carrageenan bio-platform for burn dressing.

    abstract：:A novel approach in fabricating anionic inter-polymeric complex polysaccharide bio-platform with enhanced mechanical, structural and chemical properties for burn wound dressings. This approach implies a facile, insitu method to design soft nano-floral inter-polymeric complexes. In particular, sodium alginate (SA) and ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.157

    authors： Zia T,Usman M,Sabir A,Shafiq M,Khan RU

    更新日期：2020-08-15 00:00:00

  • Chaperone-like activity of heme group against amyloid-like fibril formation by hen egg ovalbumin: possible mechanism of action.

    abstract：:It is well accepted that porphyrins related to heme, are effectively able to act as pharmaceutical. For instance, they were found to interfere with the aggregation of beta-amyloid peptide. In present study, the influence of heme concentration on the amyloid-type aggregation of ovalbumin was investigated. We provided e...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2008.10.011

    authors： Khodarahmi R,Soori H,Karimi SA

    更新日期：2009-01-01 00:00:00

  • Synthesis of anionic chitosan surfactant and application in silver nanoparticles preparation and corrosion inhibition of steel.

    abstract：:Three anionic chitosan surfactant with different hydrophobic tails labeled Chitosan-R8, Chitosan-R12 and Chitosan-R16 were prepared and their surface behavior in aqueous solution was determined by surface tension measurements at three different temperatures 20, 40 and 60 °C. The affinity of the synthesized anionic chi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.184

    authors： Badr EA,Hefni HHH,Shafek SH,Shaban SM

    更新日期：2020-08-15 00:00:00

  • Bacterial cellulose in biomedical applications: A review.

    abstract：:Bacterial cellulose (BC) derived materials represents major advances to the current regenerative and diagnostic medicine. BC is a highly pure, biocompatible and versatile material that can be utilized in several applications - individually or in the combination with different components (e.g. biopolymers and nanoparti...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2017.05.171

    authors： Picheth GF,Pirich CL,Sierakowski MR,Woehl MA,Sakakibara CN,de Souza CF,Martin AA,da Silva R,de Freitas RA

    更新日期：2017-11-01 00:00:00

  • Transcriptomic analysis of differentially expressed genes and related pathways in Harmonia axyridis after sulfoxaflor exposure.

    abstract：:Harmonia axyridis (Pallas) is a major biological control agent that is indirectly threatened by sulfoxaflor insecticide applications targeting pests in agro-ecosystems. However, the genome-wide response of H. axyridis to sulfoxaflor remains largely unknown. Here, we used high-throughput RNA-seq technology to character...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.07.032

    authors： Nawaz M,Hafeez M,Mabubu JI,Dawar FU,Li X,Khan MM,Hua H,Cai W

    更新日期：2018-11-01 00:00:00

  • Cross-linked chitosan in nano and bead scales as drug carriers for betamethasone and tetracycline.

    abstract：:Chitosan nanoparticles and chitosan beads were synthesized through the ionic gelation procedure in which sodium citrate was used as the cross-linking agent. The prepared nanoparticles were characterized by using transmission electron microscopy (TEM), X-ray diffraction (XRD), zeta potential, and Fourier transform infr...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.03.094

    authors： Taghizadeh MT,Ashassi-Sorkhabi H,Afkari R,Kazempour A

    更新日期：2019-06-15 00:00:00

  • Anti-tumor activity and the mechanism of a green tea (Camellia sinensis) polysaccharide on prostate cancer.

    abstract：:In this study, a homogeneous polysaccharide (GTP), with a molecular weight of 7.0 × 104 Da, was isolated from Green tea, which was only composed of glucose. The antitumor effects of GTP on prostate cancer (PC) cell line along with the possible mechanism was examined. First, we investigate the potential role of microRN...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.10.101

    authors： Yang K,Gao ZY,Li TQ,Song W,Xiao W,Zheng J,Chen H,Chen GH,Zou HY

    更新日期：2019-02-01 00:00:00

  • Intelligent and active furcellaran-gelatin films containing green or pu-erh tea extracts: Characterization, antioxidant and antimicrobial potential.

    abstract：:Biodegradable films from furcellaran and gelatin (FUR/GEL) with pu-erh (RTE) and green tea (GTE) water extracts (TEs) were obtained by a casting method. The films were examined in terms of physical properties (thickness, density, water solubility, water content, degree of swelling, color), antioxidant properties (DPPH...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.11.008

    authors： Jamróz E,Kulawik P,Krzyściak P,Talaga-Ćwiertnia K,Juszczak L

    更新日期：2019-02-01 00:00:00

  • Antifungal property of quaternized chitosan and its derivatives.

    abstract：:Five water-soluble chitosan derivatives were carried out by quaternizing either iodomethane or N-(3-chloro-2-hydroxypropyl) trimethylammonium chloride (Quat188) as a quaternizing agent under basic condition. The degree of quaternization (DQ) ranged between 28±2% and 90±2%. The antifungal activity was evaluated by usin...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2011.11.004

    authors： Sajomsang W,Gonil P,Saesoo S,Ovatlarnporn C

    更新日期：2012-01-01 00:00:00

  • Alginate-magnetic short nanofibers 3D composite hydrogel enhances the encapsulated human olfactory mucosa stem cells bioactivity for potential nerve regeneration application.

    abstract：:The design of 3D hydrogel constructs to elicit highly controlled cell response is a major field of interest in developing tissue engineering. The bioactivity of encapsulated cells inside pure alginate hydrogel is limited by its relatively inertness. Combining short nanofibers within a hydrogel serves as a promising me...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.11.199

    authors： Karimi S,Bagher Z,Najmoddin N,Simorgh S,Pezeshki-Modaress M

    更新日期：2021-01-15 00:00:00

  • Study the effect of trypsin enzyme activity on the screening of applying frontal affinity chromatography.

    abstract：:Frontal affinity chromatography (FAC) combined with enzyme has been widely used for drug screening. In this paper, the effect of target enzyme activity on screening of bioactive compounds was studied through applying FAC. Trypsin with different degree of inactivation were prepared as target enzyme by thermal denaturat...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.07.218

    authors： Qian J,Zhao C,Tong J,Jiang S,Zhang Z,Lu S,Guo H

    更新日期：2019-10-15 00:00:00

  • Purification and partial characterization of coxsackievirus B3 2A protease expressed in Escherichia coli.

    abstract：:Reported here is the overexpression, purification and partial characterization of recombinant coxsakievirus B3 2A protease (CVB3 2Apro) from bacterial cells transformed with a plasmid containing the CVB3 2Apro cDNA sequences. The structural investigation showed that the protein contains mostly beta-strand elements and...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2008.05.008

    authors： Maghsoudi N,Khodagholi F,Sadjadi M,Zeinodini M,Sabbaghian M

    更新日期：2008-10-01 00:00:00

  • Helicoidal self-ordering of cellulose microfibrils in aqueous suspension.

    abstract：:In many skeletal support systems of plants and animals, cellulose, chitin, and collagen occur in the form of microfibrils ordered in a chiral nematic fashion (helicoids). However, these structures remain poorly understood due to the many constituents present in biological tissues. Here we report an in vitro system tha...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(05)80008-x

    authors： Revol JF,Bradford H,Giasson J,Marchessault RH,Gray DG

    更新日期：1992-06-01 00:00:00

  • 4- Substituted sampangine derivatives: Novel acetylcholinesterase and β-myloid aggregation inhibitors.

    abstract：:A series of 4- substituted sampangine derivatives (4-aminoalkylaminosampangine Ar-NH(CH2)nNR1R2) has been designed, synthesized, and tested for their ability to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and β-myloid (Aβ) aggregation. The synthetic compounds exhibited high AChE inhibitory activi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.10.157

    authors： Chen KL,Gan L,Wu ZH,Qin JF,Liao WX,Tang H

    更新日期：2018-02-01 00:00:00

  • Development of three-dimensional bacterial cellulose/chitosan scaffolds: Analysis of cell-scaffold interaction for potential application in the diagnosis of ovarian cancer.

    abstract：:Bacterial cellulose (BC) has emerged as a biomaterial for diverse biomedical applications owing to its unique structural, physico-chemical, mechanical, and biological features. Its porous geometry and three-dimensional fibrous structure allow the impregnation of various materials into its matrix. The current study was...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.07.050

    authors： Ul-Islam M,Subhan F,Islam SU,Khan S,Shah N,Manan S,Ullah MW,Yang G

    更新日期：2019-09-15 00:00:00

  • E.p.r. studies of photolysis of nitrosyl haemoglobin at low temperatures.

    abstract：:Photolysis of HbNO has been studied from 6.2 K to 15.5 K by electron spin resonance during and after continuous illumination. Non-exponential kinetics of both dissociation and reassociation of NO was observed. The prolonged illumination separates the fast and slow ligands. This picture is consistent with NO tunnelling...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/0141-8130(90)90083-m

    authors： Linhares MP,el-Jaick LJ,Bemski G,Wajnberg E

    更新日期：1990-02-01 00:00:00

  • Magnetic field-driven drug release from modified iron oxide-integrated polysaccharide hydrogel.

    abstract：:Salecan is a novel water-soluble extracellular β-glucan and suitable for the hydrogel preparation due to its excellent physicochemical and biological properties. The present article describes the fabrication and characterization of a pH/magnetic field-driven hydrogel based on salecan-g-poly(vinylacetic acid-co-2-hydro...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.12.018

    authors： Hu X,Wang Y,Zhang L,Xu M,Zhang J,Dong W

    更新日期：2018-03-01 00:00:00

  • TPR domain of Ser/Thr phosphatase of Aspergillus oryzae shows no auto-inhibitory effect on the dephosphorylation activity.

    abstract：:A Ser/Thr phosphatase gene cloned from Aspergillus oryzae, aoppt, revealed that the tetratricopeptide repeat (TPR) and catalytic domains of the full-length AoPPT are located at the N- and C-terminal regions, respectively, similar to those of human Ser/Thr phosphatase 5 (PP5) and yeast Ppt1. Four different regions of A...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2007.03.005

    authors： Feng B,Zhao CH,Tanaka S,Imanaka H,Imamura K,Nakanishi K

    更新日期：2007-08-01 00:00:00

  • A novel matrix for the immobilization of acetylcholinesterase.

    abstract：:In this study, a new matrix for immobilization of acetylcholinesterase was investigated by using alginate and kappa-carrageenan. The effects of pH, temperature, storage and thermal stability on the free and immobilized acetylcholinesterase activity were examined. Maximum reaction rate (V(max)) and Michaelis-Menten con...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2005.10.003

    authors： Sahin F,Demirel G,Tümtürk H

    更新日期：2005-11-15 00:00:00

  • Purification and structural characterization of a novel antioxidant and antibacterial protein from Arca inflata.

    abstract：:A novel protein (J2-C4) with antioxidant and antibacterial activities was purified from the edible portion of Arca inflata. The purity of J2-C4 was measured to be 97.62% by RP-HPLC analysis, and the molecular weight was 20,537.0 Da by ESI-MS/MS. The isoelectric point of J2-C4 was determined to be 5.18 by IEF-PAGE. Sec...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.05.008

    authors： Wang W,Shi H,Zhu J,Li C,Song L,Yu R

    更新日期：2018-09-01 00:00:00

  • Physical properties and structure of aquatic silk fiber from Stenopsyche marmorata.

    abstract：:To study the properties and structure of aquatic silk, nest-spinning hydropsychid caddisfly (Stenopsyche marmorata) larva were collected from a Japanese river and the silk glands were removed from the larva by dissecting and dried on the glass plate at room temperature. The silk fibers were obtained by removing fibrou...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2009.10.003

    authors： Tsukada M,Khan MM,Inoue E,Kimura G,Hun JY,Mishima M,Hirabayashi K

    更新日期：2010-01-01 00:00:00

  • Immunostimulatory and anti-allergic potential of novel heterotrimeric lectin from seeds of Zizyphus mauritiana Lam.

    abstract：:Zizyphus mauritiana Lam. seeds (ZMS) have been used medicinally as sedative or hypnotic drugs in most of Asian countries. ZMS has significant benefits to the human health. Therefore, we have evaluated immunomodulatory effect of lectin extracted from these ZMSL in both in vitro and in vivo study. Anaphylaxis is a sever...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2021.01.027

    authors： Butle AB,Talmale SA,Jadhao VV,Patil MB,Lambat TL

    更新日期：2021-01-09 00:00:00

  • Structural-functional insights and studies on saccharide binding of Sophora japonica seed lectin.

    abstract：:Functional and conformational transitions of the Sophora japonica seed lectin (SJL) were studied in detail using bioinformatics and biophysical tools. Homology model of the lectin displayed all the characteristics of the legume lectin monomer and the experimental observations correlated well with the structural inform...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.05.047

    authors： Yadav P,Shahane G,Ramasamy S,Sengupta D,Gaikwad S

    更新日期：2016-10-01 00:00:00

  • Pectin-non-starch nanofibers biocomposites as novel gastrointestinal-resistant prebiotics.

    abstract：:Incorporation of nanofibers of chitin (NC), lignocellulose (NLC) and bacterial cellulose (BNC) in pectin was studied to improve prebiotic activity and gastrointestinal resistance of the pectin-nanofibers biocomposites for protection of probiotics under simulated gastrointestinal conditions. The biocomposites were prep...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.10.011

    authors： Khorasani AC,Shojaosadati SA

    更新日期：2017-01-01 00:00:00

  • Ginger polysaccharides induced cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.

    abstract：:In this study, ginger polysaccharide (GP) was obtained from ginger by enzymatic method, its chemical properties and antitumor activity were investigated. The results indicated that the composition and proportion of GP were l‑rhamnose, d‑arabinose, d‑mannose, d‑glucose and d‑galactose in a molar ratio of 3.64:5.37:3.04...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.10.169

    authors： Wang Y,Wang S,Song R,Cai J,Xu J,Tang X,Li N

    更新日期：2019-02-15 00:00:00

  • Production of exopolysaccharides by Acinetobacter strains in a controlled fed-batch fermentation process using soap stock oil (SSO) as carbon source.

    abstract：:The production of two extracellular capsular heteropolysaccharides by two different Acinetobacter strains has been studied in separate controlled fermentation processes with a view to their industrial applications as specific dispersing agents. The first, emulsan, is an extracellular polyanionic amphipathic heteropoly...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/0141-8130(90)90066-j

    authors： Shabtai Y

    更新日期：1990-04-01 00:00:00