Abstract:
:Chitosan nanoparticles and chitosan beads were synthesized through the ionic gelation procedure in which sodium citrate was used as the cross-linking agent. The prepared nanoparticles were characterized by using transmission electron microscopy (TEM), X-ray diffraction (XRD), zeta potential, and Fourier transform infrared (FT-IR) spectroscopy. The synthesized nanoparticles and beads were examined as drug carriers for controlled release of two important drugs including betamethasone and tetracycline. For this purpose, various properties such as swelling behavior, loading capacity, encapsulation efficiency, and release degree of the particles were obtained. The effect of pH on the aforementioned parameters was also studied. The results indicated that the amount of drug released from chitosan nanoparticles is lower than that released from chitosan beads. It was also found that the release degree for both of the drugs at the pH of 4.8 is much larger than that at the pH of 7.4.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Taghizadeh MT,Ashassi-Sorkhabi H,Afkari R,Kazempour Adoi
10.1016/j.ijbiomac.2019.03.094subject
Has Abstractpub_date
2019-06-15 00:00:00pages
581-588eissn
0141-8130issn
1879-0003pii
S0141-8130(18)35329-7journal_volume
131pub_type
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