当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Novel pH-sensitive blend microspheres for controlled release of nifedipine--an antihypertensive drug.

Novel pH-sensitive blend microspheres for controlled release of nifedipine--an antihypertensive drug.

Abstract：

:Water-soluble acrylamide (AAm)-grafted-chitosan (CS) copolymer (AAm-g-CS) was synthesized using potassium persulfate (PPS) initiator from which interpenetrating polymer network (IPN) microspheres were prepared by water-in-oil (w/o) emulsion that are cross-linked with glutaraldehyde (GA) and used for encapsulating nifedipine (NFD). Microspheres were coated with sodium alginate (NaAlg) to enhance their pH-sensitivity for extending the release time of NFD up to 14 h, releasing with 93% of NFD. The coated and uncoated microspheres were characterized by Fourier transform infrared spectra (FTIR) and differential scanning calorimetry (DSC) to understand chemical interactions and blend compatibility. Morphology and particle size of the microspheres were assessed by scanning electron microscopy (SEM) and particle zeta analyzer, respectively. Swelling and in vitro release experiments were performed in pH 1.2 and 7.4 buffer media, which showed a dependence on IPN blend composition, extent of cross-linking and amount of AAm used. Empirical analysis of drug patterns suggested the differences between NaAlg coated and uncoated microspheres.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Phadke KV,Manjeshwar LS,Aminabhavi TM

doi

10.1016/j.ijbiomac.2015.01.045

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

505-14

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(15)00056-2

journal_volume

75

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Lactic acid oligomer (OLLA) grafted gum arabic based green adhesive for structural applications.

    abstract：:L-Lactic acid (LA)-grafted-gum arabic (GA) graft copolymer [OLLA-g-GA] was prepared by using microwave heating in which the hydrophilic GA was grafted with insitu grown lactic acid oligomer. The grafting at OH and NH groups in GA backbone with oligo-(l-lactic acid) (OLLA) chains proved with the help of FTIR and NMR an...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.07.199

    authors： Tripathi N,Katiyar V

    更新日期：2018-12-01 00:00:00

  • Effect of locust bean gum-sodium alginate coatings incorporated with daphnetin emulsions on the quality of Scophthalmus maximus at refrigerated condition.

    abstract：:In this study, the microbiological, physicochemical, and flavor changes of turbot (Scophthalmus maximus) coated with a composite active coating of locust bean gum (LBG) and sodium alginate (SA) supplemented with daphnetin emulsions (0.16, 0.32, 0.64 mg·mL-1) were determined during 18 days of refrigerated storage (4 ± ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.12.089

    authors： Liu W,Mei J,Xie J

    更新日期：2021-02-15 00:00:00

  • Molecular and biochemical characterization of All0580 as a methylglyoxal detoxifying glyoxalase II of Anabaena sp. PCC7120 that confers abiotic stress tolerance in E. coli.

    abstract：:Abiotic stresses enhance cellular reactive oxygen species (ROS) level which results in toxic methylglyoxal (MG) production. Glyoxalases catalyze the conversion of toxic MG into non-toxic lactic acid whose properties and function are still unknown in cyanobacteria. This is the first attempt to characterize All0580 from...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.11.172

    authors： Rai S,Yadav S,Rai R,Chatterjee A,Singh S,Rai LC

    更新日期：2019-03-01 00:00:00

  • GH43 endo-arabinanase from Bacillus licheniformis: Structure, activity and unexpected synergistic effect on cellulose enzymatic hydrolysis.

    abstract：:The hydrolysis of the plant biomass provides many interesting opportunities for the generation of building blocks for the green chemistry industrial applications. An important progress has been made for the hydrolysis of the cellulosic component of the biomass while, for the hemicellulosic components, the advances are...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.05.157

    authors： Farro EGS,Leite AET,Silva IA,Filgueiras JG,de Azevedo ER,Polikarpov I,Nascimento AS

    更新日期：2018-10-01 00:00:00

  • Susceptibilities of bacterial cellulose containing N-acetylglucosamine residues for cellulolytic and chitinolytic enzymes.

    abstract：:Detailed characterization of enzyme susceptibility of bacterial cellulose containing N-acetylglucosamine (GlcNAc) residues (N-AcGBC) which possess high susceptibility for cellulase and lysozyme and slight susceptibility for chitinase was studied. Turbidimetric lysozyme assay of N-AcGBC showed that (i) the susceptibili...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(05)80076-5

    authors： Ogawa R,Miura Y,Tokura S,Koriyama T

    更新日期：1992-12-01 00:00:00

  • Characterization of the mitochondrial genomes of three species in the ectomycorrhizal genus Cantharellus and phylogeny of Agaricomycetes.

    abstract：:Cantharellus is a large ectomycorrhizal genus. Here, we assembled and annotated the mitochondrial genomes of C. lutescens, C. appalachiensis, and two specimens of C. cibarius. We found that all four mitochondrial genomes were circular and between 56,786 bp and 80,736 bp, long. The length and GC content of the protein-...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.06.129

    authors： Li Q,Liao M,Yang M,Xiong C,Jin X,Chen Z,Huang W

    更新日期：2018-10-15 00:00:00

  • Lignin from oil palm empty fruit bunches: Characterization, biological activities and application in green synthesis of silver nanoparticles.

    abstract：:Lignin was extracted from oil palm empty fruit bunches under four different conditions. The lignin samples were characterized and employed in the green synthesis of silver nanoparticles. Two-dimensional HSQC NMR analysis showed that lignins extracted under more aggressive conditions (3.5% acid, 60 min) exhibited less ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.11.104

    authors： Zevallos Torres LA,Woiciechowski AL,Oliveira de Andrade Tanobe V,Zandoná Filho A,Alves de Freitas R,Noseda MD,Saito Szameitat E,Faulds C,Coutinho P,Bertrand E,Soccol CR

    更新日期：2021-01-15 00:00:00

  • Stability of halophilic proteins: from dipeptide attributes to discrimination classifier.

    abstract：:To investigate the molecular features responsible for protein halophilicity is of great significance for understanding the structure basis of protein halo-stability and would help to develop a practical strategy for designing halophilic proteins. In this work, we have systematically analyzed the dipeptide composition ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.10.031

    authors： Zhang G,Huihua G,Yi L

    更新日期：2013-02-01 00:00:00

  • RNA sequencing revealed the abnormal transcriptional profile in cloned bovine embryos.

    abstract：:Somatic cell nuclear transfer (SCNT) has potential applications in agriculture and biomedicine, but the efficiency of cloning is still low. In this study, the transcriptional profiles in cloned and fertilized embryos were measured and compared by RNA sequencing. The 2-cell embryos were detected to identify the earlies...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.02.026

    authors： Zhang L,Yu M,Xu H,Wei X,Liu Y,Huang C,Chen H,Guo Z

    更新日期：2020-05-01 00:00:00

  • Laccase immobilization on the tailored cellulose-based Granocel carriers.

    abstract：:Extracellular laccase produced by Cerrena unicolor was immobilized by adsorption or covalent bonds formation on the cellulose-based carrier Granocel. Immobilization was optimized by changing the anchor groups and the methods of activation/immobilization. On the base of measured activity and stability of immobilized pr...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2007.09.014

    authors： Rekuć A,Kruczkiewicz P,Jastrzembska B,Liesiene J,Peczyńska-Czoch W,Bryjak J

    更新日期：2008-03-01 00:00:00

  • Vaccinomics strategy to concoct a promising subunit vaccine for visceral leishmaniasis targeting sandfly and leishmania antigens.

    abstract：:Visceral leishmaniasis (VL) has been declared as one of the most severely neglected tropical diseases by the World Health Organization report 2017. Cumulative incidences of treatment failure and drug resistance, demanding a potential treatment and preventive strategy for VL. In this study, we have devised a multi-epit...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.097

    authors： Ojha R,Pandey RK,Prajapati VK

    更新日期：2020-08-01 00:00:00

  • Thermoplastic cassava starch/poly(lactic acid) blend reinforced with coir fibres.

    abstract：:One way to obtain more benefit from coconut waste is to utilise coir fibre (CF) as reinforcement in biodegradable plastics. The current work aims to study the effect of CF on the performance of a thermoplastic starch (TPS)/poly(lactic acid) (PLA) blend. TPS/PLA/CF biocomposites with a constant TPS: PLA ratio of 60:40 ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.121

    authors： Chotiprayon P,Chaisawad B,Yoksan R

    更新日期：2020-08-01 00:00:00

  • Effects of manganese (II) on Bacillus licheniformis ATCC 9945A physiology and gamma-poly(glutamic acid) formation.

    abstract：:Bacillus licheniformis ATCC 9945A was cultivated in shake flasks using citrate (12 gl-1), glutamate (20 gl-1) and glycerol (80 gl-1) as carbon sources for cell growth and gamma-poly(glutamic acid) (gamma-PGA) production. The effect of the MnSO4 concentration in the medium over a range from 0.0 to 615 microns was studi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/0141-8130(95)98153-p

    authors： Cromwick AM,Gross RA

    更新日期：1995-10-01 00:00:00

  • Study of the mechanical degradation mechanism of guar gum in turbulent flow by FTIR.

    abstract：:Guar gum is used in low concentrations as a drag reducing agent in turbulent flows to significantly accelerate flow in oil pipelines, oil well operations and aqueous systems. Drag reduction also promotes a decrease in energy demand in pumping systems. However, the polymers undergo mechanical degradation and lose the a...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.09.214

    authors： Motta MVL,de Castro EVR,Muri EJB,Costalonga ML,Loureiro BV,Filgueiras PR

    更新日期：2019-01-01 00:00:00

  • Carbon dot festooned and surface passivated graphene-reinforced chitosan construct for tumor-targeted delivery of TNF-α gene.

    abstract：:Gene therapy is a promising alternative that ensures effective treatment and cure for cancer. Here, we report graphene-reinforced chitosan (CS) construct based non-viral vector for tumor-targeted gene therapy. The therapeutic gene, pDNA-TNF-α, was loaded on to chitosan-carboxylated graphene oxide (CS-CGO) construct vi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.01.174

    authors： Jaleel JA,Ashraf SM,Rathinasamy K,Pramod K

    更新日期：2019-04-15 00:00:00

  • Catalytic biosynthesis of levan and short-chain fructooligosaccharides from sucrose-containing feedstocks by employing the levansucrase from Leuconostoc mesenteroides MTCC10508.

    abstract：:Levansucrase gene (LmLEVS) was cloned from Leuconostoc mesenteroides MTCC 10508. The heterologous expression and purification of the truncated (TrLmLEVS) gene, lacking the N-terminal signal peptide, was performed in Escherichia coli. The recombinant enzyme (TrLmLEVS) was physico-kinetically characterized using sucrose...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.01.070

    authors： Jadaun JS,Narnoliya LK,Agarwal N,Singh SP

    更新日期：2019-04-15 00:00:00

  • Understanding the adhesion mechanism of a mucin binding domain from Lactobacillus fermentum and its role in enteropathogen exclusion.

    abstract：:Lactobacillus species possesses surface exposed Mucin Binding Protein (MucBP) which plays a role in adhesion to gastrointestinal mucin. MucBP contains one or more mucin binding domain (MBD), the functionality of which has yet not been characterized thoroughly. Here, we have characterized a 93-amino acid MBD (MBD93) of...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.10.107

    authors： Chatterjee M,Pushkaran AC,Vasudevan AK,Menon KKN,Biswas R,Mohan CG

    更新日期：2018-04-15 00:00:00

  • Two novel lipases purified from rice bran displaying lipolytic and esterification activities.

    abstract：:In this study, two novel lipases, rice bran lipase 1 (RBL1) and rice bran lipase 2 (RBL2), were first identified in rice (Oryza sativa) bran. Through the purification by ammonium sulfate precipitation, ion-exchange chromatography and size-exclusion chromatography, RBL1 and RBL2 were purified to 36- and 339-fold with t...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.08.026

    authors： Chen CC,Gao GJ,Kao AL,Tsai CT,Tsai ZC

    更新日期：2019-10-15 00:00:00

  • NMR studies on the solution structure of a deletion mutant of the transcarboxylase biotin carrier subunit.

    abstract：:A deletion mutant of the transcarboxylase biotin carrier protein was completely labeled with 13C and 15N. A multitude of 2D and 3D NMR spectra were recorded and assigned. An NMR solution structure was derived from the data and compared in detail with the recently published structure of the wild-type. It is shown that ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(02)00033-8

    authors： Jank MM,Sadowsky JD,Peikert C,Berger S

    更新日期：2002-10-01 00:00:00

  • Fabrication of a novel low-cost superoleophilic nonanyl chitosan-poly (butyl acrylate) grafted copolymer for the adsorptive removal of crude oil spills.

    abstract：:A novel superoleophilic-hydrophobic nonanyl chitosan-poly (butyl acrylate) grafted copolymer was fabricated as a low-cost oil-adsorbent. Chitosan (CS) was coupled with a hydrophobic nonanal (N) to form nonanyl chitosan (NCS) schiff base, and followed by grafting with butyl acrylate monomers (ButA). The grafted copolym...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.08.169

    authors： Omer AM,Khalifa RE,Tamer TM,Elnouby M,Hamed AM,Ammar YA,Ali AA,Gouda M,Eldin MSM

    更新日期：2019-11-01 00:00:00

  • Preparation of chitosan derivative with polyethylene glycol side chains for porous structure without specific processing technique.

    abstract：:The graft copolymer, chitosan-g-polyethylene glycol (PEG), was prepared through graft polymerization of PEG chains to chitosan due to the esterification reaction between PEG and 6-O-succinate-N-phthaloyl-chitosan (PHCSSA). The graft copolymer with porous structure was observed from scanning electron micrographs. It is...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2006.02.008

    authors： Huang M,Liu L,Zhang G,Yuan G,Fang Y

    更新日期：2006-05-30 00:00:00

  • Synthesis and characterization of a new soluble soybean polysaccharide-iron(III) complex using ion exchange column.

    abstract：:A new ion exchange column method was investigated to synthesize the soluble soybean polysaccharide-iron(III) complex (SSPS-FeIII1) using soluble soybean polysaccharides (SSPS). The feasibility of ion exchange column reaction was explored firstly. Results indicated the D730 anion macroporous adsorption resin could effe...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.11.038

    authors： Gao W,Huang Y,He R,Zeng XA

    更新日期：2018-03-01 00:00:00

  • Biopolymers - Calcium phosphates composites with inclusions of magnetic nanoparticles for bone tissue engineering.

    abstract：:Composites based on combination of biopolymers (chitosan, hyaluronic acid and bovine serum albumin or gelatin), calcium phosphates (CP) and magnetic nanoparticles have been prepared by a biomimetic co-precipitation method. The biomimetic strategy is inspired by natural mineralization processes, where the synthesized m...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.12.083

    authors： Cojocaru FD,Balan V,Popa MI,Lobiuc A,Antoniac A,Antoniac IV,Verestiuc L

    更新日期：2019-03-15 00:00:00

  • Chemical and biological characterization of polysaccharides isolated from Ilex paraguariensis A. St.-Hil.

    abstract：:The potential gastroprotection of polysaccharides (SP) isolated from maté (Ilex paraguariensis) leaves of different growth stages, under different sunlight conditions and of processing methods were evaluated. The SP consist of type I arabinogalactan (AG1) containing a (1→4)-linked β-Galp chain, with substituents of ar...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.04.038

    authors： Maria-Ferreira D,Dartora N,da Silva LM,Pereira IT,de Souza LM,Ritter DS,Iacomini M,Werner MF,Sassaki GL,Baggio CH

    更新日期：2013-08-01 00:00:00

  • pH dependent green synthesis of gold nanoparticles by completely C6-carboxylated curdlan under high temperature and various pH conditions.

    abstract：:A C6-carboxylated curdlan (C6-Cc) obtained from 4-acetamido-TEMPO-mediated oxidation of curdlan was used both as a reducing and stabilizing agent for green synthesis of pH-responsive AuNPs, which was carried out by controlling the pH of the C6-Cc solution at a high temperature (100°C). C6-Cc presented a semi-flexible ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.08.029

    authors： Qiu WY,Wang K,Wang YY,Ding ZC,Wu LX,Cai WD,Yan JK

    更新日期：2018-01-01 00:00:00

  • Preparation and characterization of polymeric nanoparticles surface modified with chitosan for target treatment of colorectal cancer.

    abstract：:5-Fluorouracil (5-FU) loaded chitosan (C) coated polylactic-co-glycolic acid (PLGA) nanoparticles [NPs] (C-5-FU PLGA NPs) and polycaprolactone [PCL] (C-5-FU PCL NPs) were employed as the carriers for cancer treatment. The prepared NPs showed the spherical shape of NPs with the particle size in the range of 188.1-302.2...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.11.098

    authors： Badran MM,Mady MM,Ghannam MM,Shakeel F

    更新日期：2017-02-01 00:00:00

  • Dibutyrylchitin nanoparticles as novel drug carrier.

    abstract：:Chitin is a ubiquitous renewable biopolymer that is significantly distributed in the natural world. Biopolymeric nanoparticles (Nps) have been developed for various biomedical applications by researchers. Here, chitin derivative, dibutyrylchitin Nps (DBC) was synthesized as a nanocarrier for drug delivery using butyri...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.11.031

    authors： Jain T,Kumar S,Dutta PK

    更新日期：2016-01-01 00:00:00

  • Microwave functionalization of titanium oxide nanoparticles with chitosan nanolayer for instantaneous microwave sorption of Cu(II) and Cd(II) from water.

    abstract：:The present study is aimed to evaluate the microwave-enforced sorption approach (MES) for instantaneous extraction and removal of trace concentration of metal ions using microwave-synthesized titanium oxide nanoparticles-bonded-chitosan nanolayer (NTiO2-NCh). The proposed and designed nanocomposite was characterized b...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.01.014

    authors： Mahmoud ME,Abou Ali SAA,Elweshahy SMT

    更新日期：2018-05-01 00:00:00

  • Renoprotective effect of ramulus mori polysaccharides on renal injury in STZ-diabetic mice.

    abstract：:Recently, increasing evidences have suggested that inflammatory stress is markedly occurred in the impaired tissue. Thus, the streptozotocin (STZ)-induced diabetic mice were used to investigate the potential renoprotective effect of ramulus mori polysaccharides (RMP) and to discuss the underlying mechanism. The result...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.09.022

    authors： Guo C,Liang T,He Q,Wei P,Zheng N,Xu L

    更新日期：2013-11-01 00:00:00

  • Effects of cataract-causing mutations W59C and W151C on βB2-crystallin structure, stability and folding.

    abstract：:β/γ-Crystallins, the predominant structural proteins in vertebrate lens with lifelong stability to maintain lens transparency, share a high similarity in their primary sequences and tertiary structures. Four conserved Trp residues have been shown to be important to γ-crystallin structure, stability and protection agai...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.05.109

    authors： Zhao WJ,Xu J,Chen XJ,Liu HH,Yao K,Yan YB

    更新日期：2017-10-01 00:00:00