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Roles of galectin-3 in metabolic disorders and tumor cell metabolism.

Abstract：

:The galactoside-binding protein galectin-3 is commonly overexpressed by cancer cells and promotes cancer progression and metastasis. Over the past few years, evidence has emerged that galectin-3 is also overexpressed in several metabolic malfunction conditions such as diabetes, obesity and atherosclerosis and is involved in the regulation of the occurrence and development of these diseases. Recently, Galectin-3 expression is shown also to be associated with glycolysis and mitochondrial metabolism in tumors, and promotes tumor metabolic reprogramming for their adaption to the microenvironment stress imposed by oxygen and nutrients deprivation. This brief review summarizes the current understanding of the roles and actions of galectin-3 in these metabolic diseases and in tumor metabolism.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Li YS,Li XT,Yu LG,Wang L,Shi ZY,Guo XL

doi

10.1016/j.ijbiomac.2019.09.118

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

463-473

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)35217-1

journal_volume

142

pub_type

杂志文章,评审

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