Abstract：
:A simple method to fabricate redox-responsive composite hydrogel films via incorporating chitosan (CS) microspheres into carboxymethyl cellulose (CMC) hydrogel using a di-sulphide cross-linker cystamine dihydrochloride (CYS) have done in this paper. Dual drugs, an anticancer, 5-Fluorouracil (5-FU) and an antibiotic, Tetracycline Hydrochloride (TH) were used as model drugs. The prepared composite hydrogel films were characterized using FTIR, SEM, rheology measurement, mechanical and swelling tests. Our results showed that the well dispersed spherical CS microspheres endowed hydrogel film increased mechanical properties and swellability. In vitro drug release displayed an accelerated release under weak acidic or reducing media. The in vitro cytotoxicity and cell apoptosis studies showed the drug-loaded composite film caused enhanced inhibition to HepG2 cells in presence of glutathione (GSH). Moreover, the film has exhibited excellent antimicrobial efficacy against E.coli and Staphylococcus aureus. Therefore, our simple and effective dual drug-loaded system has the potential to be used for cancer therapy in the future.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Wang F,Zhang Q,Li X,Huang K,Shao W,Yao D,Huang Cdoi
10.1016/j.ijbiomac.2019.05.049subject
Has Abstractpub_date
2019-08-01 00:00:00pages
413-421eissn
0141-8130issn
1879-0003pii
S0141-8130(19)30703-2journal_volume
134pub_type
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. ...
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journal_title：International journal of biological macromolecules
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