Abstract:
:Chitosan was chemically modified through a four-step procedure. First, the amino groups of chitosan have reacted with benzaldehyde (Derivative 1); second, hydroxyl groups on C6 of Derivative 1 have reacted with epichlorohydrin (Derivative 2); third, the epoxy groups of Derivative 2 have reacted with 4-aminosalicylic acid (Derivative 3); and fourth, benzaldehyde moieties of Derivative 3 have been removed to retrieve the amino groups (Derivative 4). For further modification, three nano-biocomposites were synthesized via impregnating three different concentrations of silver nanoparticles inside Derivative 4. These derivatives and Derivative 4/AgNP composites were structurally identified using elemental analysis, FTIR, XPS, 1H NMR, XRD, SEM, EDS and TEM techniques. These derivatives and Derivative 4/AgNP composites have superior antimicrobial activities than virgin chitosan. Some of them have inhibition zone analogous or superior than the utilized reference drugs. Cytotoxic activity of Derivative 4 and Derivative 4/AgNPs-5 composite indicated that these materials are safe on normal human cells. Accordingly, combinations between chitosan and functional groups derived from the different modifiers in addition to AgNPs within a single structure have extraordinarily enhanced the efficiency of chitosan. It might be deemed as a path to attain promising frameworks which are taken as proper competitors for antimicrobial materials in biomedical fields.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Elmehbad NY,Mohamed NAdoi
10.1016/j.ijbiomac.2020.01.298subject
Has Abstractpub_date
2020-05-15 00:00:00pages
92-103eissn
0141-8130issn
1879-0003pii
S0141-8130(19)39621-7journal_volume
151pub_type
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