Abstract：
:Ultrasound treatment was applied to modify the physicochemical properties of an exopolysaccharide from mycelial culture of Schizophyllum commune. Molecular weight (MW) degradation, viscosity and anti-inflammatory property of ultrasonic treated polysaccharide were optimized with response surface methodology. The best ultrasonic parameters were obtained with a three-variable-three-level Box-Behnken design. The optimized conditions for efficient anti-inflammatory activity are initial concentration at 0.4%, ultrasonic power at 600W, and duration of ultrasonic irradiation for 9min. Under these conditions, the nitric oxide inhibition rate was 95±0.03% which agreed closely with the predicted value (96%). Average MW of polysaccharide decreased after ultrasonic treatments. The viscosity of degraded polysaccharide dropped compared with native polysaccharide. The anti-inflammatory activity was improved by ultrasound treatment. The results suggested that ultrasound treatment is an effective approach to decrease the MW of polysaccharide with high anti-inflammatory activity. Ultrasonic treatment is a viable modification technology for high MW polymer materials.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Du B,Zeng H,Yang Y,Bian Z,Xu Bdoi
10.1016/j.ijbiomac.2016.05.052subject
Has Abstractpub_date
2016-10-01 00:00:00pages
100-5eissn
0141-8130issn
1879-0003pii
S0141-8130(16)30463-9journal_volume
91pub_type
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