当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > The antitumor activity of a red alga polysaccharide complexes carrying 5-fluorouracil.

The antitumor activity of a red alga polysaccharide complexes carrying 5-fluorouracil.

Abstract：

:Porphyran is a sulfated galactan isolated from red algae Porphyra haitanensis, and have been reported to have many kinds of biological activities such as antitumor activity. In order to provide a water-soluble macromolecule prodrug of 5-Fu showing slow release of 5-Fu and reducing side-effect, we carried out fixation of 5-Fu to porphyran at 6-position. In this study, the antitumor and immunomodulation activities of low MW porphyran carrying 5-Fu on transplanted S180 tumor mice were studied. Weight of immune organ, proliferation ratio of lymphocyte concentration of TNF-α and NO from the transplanted S180 tumor mice were also determined. Results indicated that the conjugate could enhance antitumor activity of 5-Fu and improve immunocompetence damaged by 5-Fu.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Wang X,Zhang Z

doi

10.1016/j.ijbiomac.2014.06.017

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

542-5

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(14)00400-0

journal_volume

69

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Pasting and paste properties of waxy rice starch as affected by hydroxypropyl methylcellulose and its viscosity.

    abstract：:The objective of this study was to investigate the impacts of hydroxypropyl methylcellulose (HPMC) and its viscosity on the pasting and paste properties of waxy rice starch (WRS). HPMC with different viscosities (low, BN50; medium, BN40M; high, BN40H) but similar substituted group contents was used. Although the total...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.10.250

    authors： Lee H,Kim HS

    更新日期：2020-06-15 00:00:00

  • Biosynthesis and native granule characteristics of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in Delftia acidovorans.

    abstract：:The ability of Delftia acidovorans to incorporate a broad range of 3-hydroxyvalerate (3HV) monomers into polyhydroxyalkanoate (PHA) copolymers was evaluated in this study. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(3HB-co-3HV)] containing 0-90 mol% of 3HV was obtained when a mixture of sodium 3-hydroxybutyrate an...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2006.11.003

    authors： Loo CY,Sudesh K

    更新日期：2007-04-10 00:00:00

  • Characterization, antioxidant activities, and inhibition on α-glucosidase activity of corn silk polysaccharides obtained by different extraction methods.

    abstract：:The polysaccharides (CSPw, CSPc, CSPa, and CSPu) were prepared by hot water extraction, acid-assisted extraction, alkaline-assisted extraction, and ultrasound-assisted extraction from corn silk, respectively. High performance gel permeation chromatography (HPGPC), fourier-transform infrared (FT-IR) spectroscopy, and s...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.09.068

    authors： Jia Y,Gao X,Xue Z,Wang Y,Lu Y,Zhang M,Panichayupakaranant P,Chen H

    更新日期：2020-11-15 00:00:00

  • Observation of in vitro cellulose synthesis by bacterial cellulose synthase with time-resolved small angle X-ray scattering.

    abstract：:Cellulose synthase is the enzyme that produces cellulose in the living organisms like plant, and has two functions: polymerizing glucose residues (polymerization) and assembling these polymerized molecules into a crystalline microfibril with a "cellulose I" crystallographic structure (crystallization). Many studies, h...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.02.167

    authors： Tajima H,Penttilä PA,Imai T,Yamamoto K,Yuguchi Y

    更新日期：2019-06-01 00:00:00

  • Cross-linking effects of carbodiimide, oxidized chitosan oligosaccharide and glutaraldehyde on acellular dermal matrix of basa fish (Pangasius bocourti).

    abstract：:Basa acellular dermal matrix (BADM) has advantages in the preparation of oral prosthetic membranes. In order to prepare high-quality BADM, a suitable cross-linking agent is necessary. In this study, acellular dermal matrix was prepared from basa fish skin and then cross-linked with carbodiimide (EDC), oxidized chitosa...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.07.019

    authors： Ma P,Wang Y,Li B,Hou H

    更新日期：2020-12-01 00:00:00

  • Chemical modification of pullulan exopolysaccharide by octenyl succinic anhydride: Optimization, physicochemical, structural and functional properties.

    abstract：:Pullulan (PU) is an exo-polysaccharide used in the food and pharmaceutical industries. However, the use of PU in different industries is limited due to its highly hydrophilic nature and consequently weakness in surface properties which can be remedied by its chemical modification with octenyl succinic anhydride (OSA)....

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.08.158

    authors： Omar-Aziz M,Yarmand MS,Khodaiyan F,Mousavi M,Gharaghani M,Kennedy JF,Hosseini SS

    更新日期：2020-12-01 00:00:00

  • Molecular structures, chemical properties and biological activities of polysaccharide from Smilax glabra rhizome.

    abstract：:The water-soluble crude polysaccharides, extracted from the rhizome of Smilax glabra, were fractionated using an anion exchange chromatography, yielding two fractions, F1 and F2. The crude and fractions (F1 and F2) mainly consisted of carbohydrates (66.7%-91.1%), proteins (7.30%-23.9%) and minor amount of sulfates (1....

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.09.138

    authors： Lee J,Li C,Surayot U,Yelithao K,Lee S,Park W,Tabarsa M,You S

    更新日期：2018-12-01 00:00:00

  • Synthesis and characterization of a novel organosilane-functionalized chitosan nanocarrier as an efficient gene delivery system: Expression of green fluorescent protein.

    abstract：:Semi-essential arginine amino acid was selected to synthesis an organosilane linker for modifying chitosan biopolymer. The novel organosilane linker which was chemically synthesized by reaction of arginine with 3‑chloropropyl trimethoxy silane, covalently bonded to the chitosan amino group. The chemical structure of r...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.11.145

    authors： Kashkouli KI,Torkzadeh-Mahani M,Mosaddegh E

    更新日期：2019-03-15 00:00:00

  • Encapsulation of Bunium persicum essential oil using chitosan nanopolymer: Preparation, characterization, antifungal assessment, and thermal stability.

    abstract：:The present study reports the antifungal, aflatoxin B1 inhibitory, and free radical scavenging activity of chitosan-based nanoencapsulatedBunium persicum Boiss. essential oil (Ne-BPEO). The chemical profile ofBPEO was identified through Gas chromatography mass spectrometry analysis where cuminaldehyde (21.23%), sabine...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.09.089

    authors： Yadav A,Kujur A,Kumar A,Singh PP,Gupta V,Prakash B

    更新日期：2020-01-01 00:00:00

  • N-terminal residues are crucial for quaternary structure and active site conformation for the phosphoserine aminotransferase from enteric human parasite E. histolytica.

    abstract：:Phosphoserine aminotransferase (PSAT) is a pyridoxal-5'phosphate (PLP)-dependent enzyme that catalyzes the second reversible step in the phosphoserine biosynthetic pathway producing serine. The crystal structure of E. histolytica PSAT (EhPSAT) complexed with PLP was elucidated at 3.0 Å resolution and the structures of...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.04.027

    authors： Singh RK,Tomar P,Dharavath S,Kumar S,Gourinath S

    更新日期：2019-07-01 00:00:00

  • Evidence of two oxidation states of copper during aggregation of hen egg white lysozyme (HEWL).

    abstract：:In vitro fibrillation of hen egg white lysozyme (HEWL) causes complete reduction of Cu(II) to Cu(I) at pH 7. Here in the present article, we have shown the presence of both Cu(II) and Cu(I) at pH 11 during fibrillation of HEWL using electron paramagnetic resonance and Raman spectroscopy. Our results suggest the existe...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.02.014

    authors： Ghosh S,Pandey NK,Bhattacharya S,Roy A,Nagy NV,Dasgupta S

    更新日期：2015-05-01 00:00:00

  • Structural characteristics and properties of the regenerated silk fibroin prepared from formic acid.

    abstract：:Structural characteristics and thermal and solution properties of the regenerated silk fibroin (SF) prepared from formic acid (FU) were compared with those of SF from water (AU). According to the turbidity and shear viscosity measurement, SF formic acid solution was stable and transparent, no molecular aggregations oc...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(01)00159-3

    authors： Um IC,Kweon HY,Park YH,Hudson S

    更新日期：2001-08-20 00:00:00

  • Highly efficient adsorption of Pb(II) from aqueous solution using amino-functionalized SBA-15/calcium alginate microspheres as adsorbent.

    abstract：:In this work, amino-functionalized Santa Barbara Amorphous-15/calcium alginate (ASBA-15@CA) microspheres were fabricated and characterized by FTIR, SEM, XRD, TGA, and XPS analyses. The Pb(II) adsorption properties of the ASBA-15@CA microspheres were studied in terms of the effects of the adsorption time, adsorbent dos...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.12.112

    authors： Song Y,Yang LY,Wang YG,Yu D,Shen J,Ouyang XK

    更新日期：2019-03-15 00:00:00

  • Structure and properties of chitin/alginate blend membranes from NaOH/urea aqueous solution.

    abstract：:Chitin/alginate (CA) blend membranes were successfully prepared from 8 wt% NaOH/4 wt% urea aqueous solution by coagulating with 0.5M CaCl(2) aqueous solution containing 5 wt% HCl. Morphology, mechanical properties, thermal stability, and antimicrobial effects of the membranes were investigated by scanning electron mic...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.08.030

    authors： Li G,Li W,Deng H,Du Y

    更新日期：2012-12-01 00:00:00

  • Toxic heavy metal cadmium removal using chitosan and polypropylene based fiber composite.

    abstract：:The aim of the present work was to evaluate the performance of polypropylene (PP)/sisal fiber (SF)/banana fiber (BF) and chitosan-based hybrid (chitosan(CS)/SF)/BF) composite materials for the adsorptive removal of cadmium (Cd) ions from water waste. Polypropylene is harnessed for its importance in forming strong comp...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.07.252

    authors： Alaswad SO,Lakshmi KB,Sudha PN,Gomathi T,Arunachalam P

    更新日期：2020-12-01 00:00:00

  • The first mitochondrial genome for Phaudidae (Lepidoptera) with phylogenetic analyses of Zygaenoidea.

    abstract：:Phauda flammans Walker belongs to Phaudidae (Lepidoptera), which is a holometabolous and leaf-eating pest that harms trees. So far, there is no mitochondrial (mt) genome reported of Phaudidae. Herein, we sequenced and annotated the complete mt genome of P. flammans representing the first mt genome of Phaudidae and pre...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.01.307

    authors： Zhang R,Li J,Geng S,Yang J,Zhang X,An Y,Li C,Cui H,Li X,Wang Y

    更新日期：2020-04-15 00:00:00

  • Anti-psoriatic and toxicity evaluation of methotrexate loaded chitin nanogel in imiquimod induced mice model.

    abstract：:Methotrexate loaded chitin nanogel (MCNG) was formulated for its topical use in psoriasis. MCNG was characterized by DLS, TEM and FTIR. The MCNG particles were spherical in shape with size of 196±14nm, having surface charge of +9.21±0.42 mv. MCNG exhibited greater swelling and drug release at acidic pH than neutral an...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.10.112

    authors： Panonnummal R,Sabitha M

    更新日期：2018-04-15 00:00:00

  • Thermal helix-coil transition in UV irradiated collagen from rat tail tendon.

    abstract：:The thermal helix-coil transition in UV irradiated collagen solution, collagen film and pieces of rat tail tendon (RTT) were compared. Their thermal stability's were determined by differential scanning calorimeter (DSC) and by viscometric measurements. The denaturation temperatures of collagen solution, film and piece...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(99)00047-1

    authors： Sionkowska A,Kamińska A

    更新日期：1999-05-01 00:00:00

  • Evaluation of microwave assisted grafted sago starch as controlled release polymeric carrier.

    abstract：:In the present investigation an attempt has been made to develop a new co-polymeric material for controlled release tablet formulations. The acrylamide grafting was successfully performed on the backbone of sago starch. The modified starch was tested for acute toxicity and drug-excipient compatibility study. The graft...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.05.008

    authors： Singh AV,Nath LK

    更新日期：2013-09-01 00:00:00

  • Role of Hsp90 and ATP in modulating apyrase activity and firefly luciferase kinetics.

    abstract：:The present manuscript describes a novel bioassay consisting of apyrase and heat shock protein 90 (Hsp90) without additional co-chaperone supplementation; intended for high-throughput screening of anti-cancer drugs and prognosis of stress. In this regard, Hsp90 and adenosine 5'-triphosphate (ATP) mediated firefly luci...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.03.110

    authors： Kirillova MA,Ranjan R,Esimbekova EN,Kratasyuk VA

    更新日期：2019-06-15 00:00:00

  • Novel insights into the treatment of SARS-CoV-2 infection: An overview of current clinical trials.

    abstract：:The emergence of the global pandemic caused by the novel SARS-CoV-2 virus has motivated scientists to find a definitive treatment or a vaccine against it in the shortest possible time. Current efforts towards this goal remain fruitless without a full understanding of the behavior of the virus and its adaptor proteins....

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2020.09.204

    authors： Oroojalian F,Haghbin A,Baradaran B,Hemmat N,Shahbazi MA,Baghi HB,Mokhtarzadeh A,Hamblin MR

    更新日期：2020-12-15 00:00:00

  • Characterization of a d-tagatose 3-epimerase from Caballeronia fortuita and its application in rare sugar production.

    abstract：:Recently, rare sugars have caused extensively attention due to their beneficial physiological functions and potential applications in food systems and medical fields. Ketose 3-epimerase (KEase) can catalyze reversibly the epimerization between ketoses which is the pivotal enzyme in Izumoring strategy and an effective ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.07.112

    authors： Li S,Chen Z,Zhang W,Guang C,Mu W

    更新日期：2019-10-01 00:00:00

  • Quantification of anti-aggregation activity of UV-irradiated α-crystallin.

    abstract：:Ultraviolet radiation is a risk factor for cataractogenesis. It is believed that enhanced rates of lens opacification and cataract formation are the results of gradual loss of chaperone-like efficiency of α-crystallin upon exposure to UV light. To characterize chaperone-like activity of α-crystallin damaged by UV irra...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.10.060

    authors： Borzova VA,Markossian KA,Muranov KO,Polyansky NB,Kleymenov SY,Kurganov BI

    更新日期：2015-02-01 00:00:00

  • Characterization of carbon nanofiber mats produced from electrospun lignin-g-polyacrylonitrile copolymer.

    abstract：:The graft copolymerization of acrylonitrile (AN) onto methanol-soluble kraft lignin (ML) was achieved through a two-step process in which AN was first polymerized with an α,α'-azobisisobutyronitrile initiator, followed by radical coupling with activated ML. A carbon nanofiber material was obtained by electrospinning a...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.10.022

    authors： Youe WJ,Lee SM,Lee SS,Lee SH,Kim YS

    更新日期：2016-01-01 00:00:00

  • Structure function relationships of transgenic starches with engineered phosphate substitution and starch branching.

    abstract：:Potato tuber starch was genetically engineered in the plant by the simultaneous antisense suppression of the starch branching enzyme (SBE) I and II isoforms. Starch prepared from 12 independent lines and three control lines were characterised with respect to structural and physical properties. The lengths of the amylo...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2005.05.006

    authors： Blennow A,Wischmann B,Houborg K,Ahmt T,Jørgensen K,Engelsen SB,Bandsholm O,Poulsen P

    更新日期：2005-08-01 00:00:00

  • Preparation of a novel Grifola frondosa polysaccharide-chromium (III) complex and its hypoglycemic and hypolipidemic activities in high fat diet and streptozotocin-induced diabetic mice.

    abstract：:Polysaccharide from Grifola frondosa is one of the best metal-ion chelating agents because of its structural characteristics and excellent functional activities. In this study, we synthesized and characterized a novel Grifola frondosa polysaccharide-chromium (III) [GFP-Cr(III)] complex. Response surface methodology (R...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.03.042

    authors： Guo WL,Shi FF,Li L,Xu JX,Chen M,Wu L,Hong JL,Qian M,Bai WD,Liu B,Zhang YY,Ni L,Rao PF,Lv XC

    更新日期：2019-06-15 00:00:00

  • Development and characterization of a fully human antibody targeting SCF/c-kit signaling.

    abstract：:CD117/c-kit, a tyrosine kinase receptor, plays a critical role in hematopoiesis, pigmentation, and fertility. The overexpression and activation of c-kit are thought to promote tumor growth and have been reported in various cancers, including leukemia, glioblastoma and mastocytosis. To disrupt the SCF/c-kit signaling a...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.05.045

    authors： Kim JO,Kim HN,Kim KH,Baek EJ,Park JY,Ha K,Heo DR,Seo MD,Park SG

    更新日期：2020-09-15 00:00:00

  • Efficiency of Ag(0)@chitosan gel beads in catalytic reduction of nitroaromatic compounds by sodium borohydride.

    abstract：:Metal-catalysed reduction of nitroaromatic compounds to aniline derivatives is a useful and important synthetic route in many applications. Metallic silver particles have gained much recent interest as efficient catalysts in catalytic reduction of nitroaromatic compounds by sodium borohydride. In the study metallic Ag...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.07.018

    authors： Sargin I

    更新日期：2019-09-15 00:00:00

  • A review: Recent advances in ultrasensitive and highly specific recognition aptasensors with various detection strategies.

    abstract：:One of the most studied topics in analytical chemistry and physics is to develop bio-sensors. Aptamers are small single-stranded RNA or DNA oligonucleotides (5-25 kDa), which have advantages in comparison to their antibodies such as physicochemical stability and high binding specificity. They are able to integrate wit...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2020.03.173

    authors： Yan SR,Foroughi MM,Safaei M,Jahani S,Ebrahimpour N,Borhani F,Rezaei Zade Baravati N,Aramesh-Boroujeni Z,Foong LK

    更新日期：2020-07-15 00:00:00

  • Synthesis of protocatechuic acid grafted chitosan copolymer: Structure characterization and in vitro neuroprotective potential.

    abstract：:Excessive free radicals can cause oxidative damage to human tissues, which results in a variety of diseases. Therefore, the development of antioxidant materials is one of the great projects in biomedical field. In this work, antioxidant protocatechuic acid (PCA) monomers were grafted onto chitosan (CS) backbones to de...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.12.019

    authors： Xu C,Guan S,Wang B,Wang S,Wang Y,Sun C,Ma X,Liu T

    更新日期：2018-04-01 00:00:00