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Quantification of anti-aggregation activity of UV-irradiated α-crystallin.

Abstract：

:Ultraviolet radiation is a risk factor for cataractogenesis. It is believed that enhanced rates of lens opacification and cataract formation are the results of gradual loss of chaperone-like efficiency of α-crystallin upon exposure to UV light. To characterize chaperone-like activity of α-crystallin damaged by UV irradiation, a test system based on dithiothreitol-induced aggregation of holo-α-lactalbumin from bovine milk was used. The adsorption capacity of α-crystallin (AC0) with respect to the target protein (α-lactalbumin) was used as a measure of anti-aggregation activity of α-crystallin. The data on SDS-PAGE testify that UV irradiation of α-crystallin results in covalent cross-linking of subunits in α-crystallin oligomers. The dependence of AC0 value on the irradiation dose was compared with the UV-induced diminution of the portion of native α-crystallin estimated from the data on differential scanning calorimetry. On the basis of such comparison a conclusion has been made that the loss in chaperone-like activity is mainly due to UV-induced denaturation of α-crystallin subunits. Cross-linking of remaining native subunits leads to an additional decrease in anti-aggregation activity.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Borzova VA,Markossian KA,Muranov KO,Polyansky NB,Kleymenov SY,Kurganov BI

doi

10.1016/j.ijbiomac.2014.10.060

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

84-91

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(14)00745-4

journal_volume

73

pub_type

杂志文章

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