当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Osteochondral and bone tissue engineering scaffold prepared from Gallus var domesticus derived demineralized bone powder combined with gellan gum for medical application.

Osteochondral and bone tissue engineering scaffold prepared from Gallus var domesticus derived demineralized bone powder combined with gellan gum for medical application.

Abstract：

:Osteochondral (OC) lesions can occur in the knee and ankle. Such lesions induce a fracture in the cartilage protecting the bone joints. Cartilage tissue shows limited self-regeneration ability, hence the tissue is avascular and lack of vascular innervation, while the bone is a unique organ with the capacity to self-repair of small defects. In this present study, we have prepared a scaffold using demineralized bone powder (DBP) extracted from Gallus gallus var domesticus (GD), and Gellan gum (GG) for OC tissue regeneration. They were characterized for their chemical, physical, mechanical and biological properties using different available techniques, in vitro bioactivity was performed in simulated body fluid for 14 days confirming the formation of bone-like apatite. The in vitro biocompatibility was analyzed using chondrocyte cells and osteogenic and chondrogenic marker gene expression using RT-PCR, in vivo experiments performed by implanting scaffold in rabbit and characterized by histology and immunofluorescent stainings. The obtained results indicated that the prepared pores scaffold was biocompatible, and promote OC regeneration and integration of newly formed tissues with the host tissues in a rabbit. The prepared 1% DBP/GG scaffold can be used as a potential and promising alternate material for OC regeneration.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Kim D,Cho HH,Thangavelu M,Song C,Kim HS,Choi MJ,Song JE,Khang G

doi

10.1016/j.ijbiomac.2020.01.191

subject

Has Abstract

pub_date

2020-04-15 00:00:00

pages

381-394

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)35238-9

journal_volume

149

pub_type

杂志文章

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