Abstract:
:Two novel chitosan derivatives modified with quaternary phosphonium salts were successfully synthesized, including tricyclohexylphosphonium acetyl chitosan chloride (TCPACSC) and triphenylphosphonium acetyl chitosan chloride (TPPACSC), and characterized by FTIR, 1H NMR, and 13C NMR spectra. The degree of substitution was also calculated by elemental analysis results. Their antifungal activities against Colletotrichum lagenarium, Watermelon fusarium, and Fusarium oxysporum were investigated in vitro using the radial growth assay, minimal inhibitory concentration, and minimum bactericidal concentration assay. The fungicidal assessment revealed that the synthesized chitosan derivatives had superior antifungal activity compared with chitosan. Especially, TPPACSC exhibited the best antifungal property with inhibitory indices of over 75% at 1.0mg/mL. The results obviously showed that quaternary phosphonium groups could effectively enhance antifungal activity of the synthesized chitosan derivatives. Meanwhile, it was also found that their antifungal activity was influenced by electron-withdrawing ability of the quaternary phosphonium salts. The synthetic strategy described here could be utilized for the development of chitosan as antifungal biomaterials.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Tan W,Zhang J,Luan F,Wei L,Chen Y,Dong F,Li Q,Guo Zdoi
10.1016/j.ijbiomac.2017.04.073subject
Has Abstractpub_date
2017-09-01 00:00:00pages
704-711eissn
0141-8130issn
1879-0003pii
S0141-8130(16)33086-0journal_volume
102pub_type
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