当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > The biomedical potential of cellulose acetate/polyurethane nanofibrous mats containing reduced graphene oxide/silver nanocomposites and curcumin: Antimicrobial performance and cutaneous wound healing.

The biomedical potential of cellulose acetate/polyurethane nanofibrous mats containing reduced graphene oxide/silver nanocomposites and curcumin: Antimicrobial performance and cutaneous wound healing.

Abstract：

:In this study, nanofibrous scaffolds were prepared from polyurethane and cellulose acetate using electrospinning. Reduced graphene oxide/silver nanocomposites, rGO/Ag, were also used into the mats due to the strong antibacterial activity of rGO/Ag nanocomposites. In order to prevent the agglomeration of silver nanoparticles, AgNPs, the nanoparticles were decorated onto the reduced graphene oxide (rGO) sheets. Initially, Graphene oxide, briefly GO, was synthesized by the improved Hummer method. Then, nanocomposites of reduced graphene oxide were decorated with Ag and were fabricated via a green and facile hydrothermal method. Thereafter, the scaffold containing rGO/Ag nanocomposites, curcumin or both of them were prepared using the electrospinning method. The obtained scaffolds were characterized by scanning electron microscopy (SEM), contact angle, tensile analysis, porosity, and water vapor transmission rate (WVTR). 3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assay, MTT, confirmed the biocompatibility of the composite nanofibers. The scaffolds were able to hinder both of the Gram-negative and Gram-positive bacteria through direct contact with them. In vivo histopathological studies indicated that the scaffold incorporated rGO/Ag nanocomposites and curcumin has the most effect on wound healing and can promote the healing rate of artificial wounds, which indicates the good biomedical potential of nanomaterial in wound healing.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Esmaeili E,Eslami-Arshaghi T,Hosseinzadeh S,Elahirad E,Jamalpoor Z,Hatamie S,Soleimani M

doi

10.1016/j.ijbiomac.2020.02.295

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

418-427

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)40691-0

journal_volume

152

pub_type

杂志文章

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