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Polymer coated mesoporous ceramic for drug delivery in bone tissue engineering.

Abstract：

:Treatment strategy for various bone fracture and defects the researchers are focusing to develop a new carrier for delivering the drug into injured area with controlled and sustained manner using biomaterials with dynamic architecture orientation. Ceramic materials are resembled with bone compositional architecture and better bioactivity, degradability as well as antimicrobial activity made its enormous application in bone tissue engineering (BTE). Current focus in regenerative medicine were orchestration of biomaterials with the capacity of loading the drugs, growth factors, ionic components to promote better healing of bone tissue. Mesoporous type materials owed a great look towards the delivery of drugs, growth factors, etc in BTE because of its unique geometry. So the guest molecules loaded with geometrically organized ceramics would deliver onto the site of injury in controlled manner also the guiding and regulation of delivery of molecules have been controlled with the polymers response to different stimulation or biochemical factors as either scaffold or encapsulated particles for bone regeneration. Hence the review aims to describing the recent progress in bone tissue engineering using the ceramic based mesoporous materials encapsulated with polymers respond to different physiochemical stimulation for the efficient and controlled delivery of drug/growth factors for better bone healing.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Subhapradha N,Abudhahir M,Aathira A,Srinivasan N,Moorthi A

doi

10.1016/j.ijbiomac.2017.11.146

subject

Has Abstract

pub_date

2018-04-15 00:00:00

pages

65-73

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(17)32760-5

journal_volume

110

pub_type

杂志文章,评审

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