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Tantalizing role of p53 molecular pathways and its coherent medications in neurodegenerative diseases.

Abstract：

:Neurodegenerative diseases are incongruous, commonly age-related disorders characterized by progressive neuronal loss, comprising the most prevalent being Alzheimer's disease, Parkinson's disease, and Huntington's disease. Perilous health states are anticipated following the neurodegeneration. Their etiology remains largely ambiguous, while various mechanisms are ascribed to their pathogenesis. A recommended conception is regarding the role of p53, as a transcription factor regulating numerous cellular pathways comprising apoptosis. Neuronal fates are a feasible occurrence that contributes to all neurodegenerative diseases. In this work, we review the research investigated the potential role of p53 in the pathogenesis of these diseases. We put special emphasis on intricate We not only describe aberrant changes in p53 level/activity observed in CNS regions affected by particular diseases but, most importantly, put special attention to the complicated reciprocal tuning connections prevailing between p53 and molecules considered in pathological hallmarks of these disorders. Natural and synthetic medications regulating p53 expression are regarded as well.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Talebi M,Talebi M,Kakouri E,Farkhondeh T,Pourbagher-Shahri AM,Tarantilis PA,Samarghandian S

doi

10.1016/j.ijbiomac.2021.01.042

subject

Has Abstract

pub_date

2021-01-10 00:00:00

pages

93-103

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(21)00060-X

journal_volume

172

pub_type

杂志文章,评审

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