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Oral administration of chitin and chitosan prevents peanut-induced anaphylaxis in a murine food allergy model.

Abstract：

:Peanut allergy is IgE-mediated type-I hypersensitivity, and T helper 2 cytokines are central to those pathogenesis. We investigated the effects of the administration of chitin and chitosan on peanut-induced hypersensitivities in mouse food allergy models. Chitin and chitosan protected mice against peanut-induced anaphylaxis reactions, and the peanut-specific IgE production decreased by up to 47% with the administration of β-chitosan. The levels of IL-5, IL-13, and IL-10 were significantly suppressed in all groups (α-chitin≥β-chitin≥β-chitosan). These results suggested that the administration of chitin and chitosan from by-products of food processing are beneficial for the prevention of food allergies.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Bae MJ,Shin HS,Kim EK,Kim J,Shon DH

doi

10.1016/j.ijbiomac.2013.06.017

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

164-8

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(13)00345-0

journal_volume

61

pub_type

杂志文章

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