当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Nanosheets-incorporated bio-composites containing natural and synthetic polymers/ceramics for bone tissue engineering.

Nanosheets-incorporated bio-composites containing natural and synthetic polymers/ceramics for bone tissue engineering.

Abstract：

:Bone is a highly integrative and dynamic tissue of the human body that is regularly modeled and remodeled by bone cells such as osteoblasts and osteoclasts. When a fraction of a bone is damaged or deformed, stem cells and bone cells under the influence of several signaling pathways regulate bone regeneration at the particular locale, but in a dilatory manner. To overcome this problem, the field of bone tissue engineering (BTE) utilizes various bio-composite scaffolds that incorporate cells and appropriate growth factors to promote osteogenesis. Nanosheets are in two-dimensional (2D)-atomic structures, and metallic and non-metallic nanosheets play a keen role in biomedical applications, including BTE. Due to their intrinsic mechanical properties such as durability and flexibility, nanosheets strengthen the bio-composite scaffolds containing natural polymers (chitosan, gelatin, and collagen), synthetic polymers, bio-ceramics, and bio-glasses. Incorporating nanosheets into bio-composites promotes the bio-functionality of the cells, such as cell adhesion and osteoblast differentiation. Hence, this review was aimed to provide a detailed study on the nanosheets-incorporated bio-composites and their properties for BTE applications.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Adithya SP,Sidharthan DS,Abhinandan R,Balagangadharan K,Selvamurugan N

doi

10.1016/j.ijbiomac.2020.08.053

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

1960-1972

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(20)34141-6

journal_volume

164

pub_type

杂志文章,评审

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