当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Molecular recognition between pancreatic lipase and natural and synthetic inhibitors.

Molecular recognition between pancreatic lipase and natural and synthetic inhibitors.

Abstract：

:Pancreatic lipase (PL) is a primary lipase critical for triacylglyceride digestion in humans and is considered as a promising target for the treatment of obesity. Although the current synthetic drugs available for treating obesity have been demonstrated to be effective in inhibiting PL, their prolonged usage results in severe side effects. Based on this argument, in this study, we evaluated the structural and energetic features linked to molecular recognition between two well-known PL inhibitors, orlistat (ORL, synthetic inhibitor) and (-)-epigallocatechin gallate (EGCG, natural inhibitor) and PL through molecular dynamics simulations and free energy calculations of ORL and EGCG at the PL binding site when it is isolated (PL) from the heterodimer complex, forming the heterodimer complex with colipase (PLCL) and lacking structural calcium. Our study showed that the binding free energy of ORL and EGCG to the target correlates with their experimental affinity tendency. The presence of the heterodimer PLCL state, the presence of structural calcium and the type of inhibitor resulted in differences in structural stability and in the map of protein-ligand and protein-protein interactions. Overall, our results suggest that the heterodimer complex and structural calcium are linked to the binding properties of PL.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Bello M,Basilio-Antonio L,Fragoso-Vázquez J,Avalos-Soriano A,Correa-Basurto J

doi

10.1016/j.ijbiomac.2017.01.150

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

855-868

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(17)30036-3

journal_volume

98

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • The effect of alkaline pretreatment on the biochemical characteristics and fibril-forming abilities of types I and II collagen extracted from bester sturgeon by-products.

    abstract：:Non-mammalian collagens have attracted increasing attention for industrial and biomedical use. We have therefore evaluated extraction conditions and the biochemical properties of collagens from aquacultured sturgeon. Pepsin-soluble type I and type II collagen were respectively extracted from the skin and notochord of ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.03.091

    authors： Meng D,Tanaka H,Kobayashi T,Hatayama H,Zhang X,Ura K,Yunoki S,Takagi Y

    更新日期：2019-06-15 00:00:00

  • Doxorubicin-loaded fucoidan capped gold nanoparticles for drug delivery and photoacoustic imaging.

    abstract：:Polymer nanoparticles are emerging as a useful tool for a wide variety of biomedical and therapeutic applications. The present study demonstrates the multifunctional doxorubicin-loaded fucoidan capped gold nanoparticles (DOX-Fu AuNPs) for drug delivery and photoacoustic imaging (PAI). Biocompatible AuNPs were synthesi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.06.007

    authors： Manivasagan P,Bharathiraja S,Bui NQ,Jang B,Oh YO,Lim IG,Oh J

    更新日期：2016-10-01 00:00:00

  • Facile synthesis of a high efficiency and durability L-citrulline flame retardant for cotton.

    abstract：:A novel flame retardant (FR), the ammonium salt of citrulline-penta (methylphosphonic acid) (ACPMPA) based on L-citrulline was synthesized, and its structure was characterized by 13C, 1H, and 31P nuclear magnetic resonance (NMR) spectroscopy. The ACPMPA flame retardant molecule contains five ammonium salts of phosphor...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.11.022

    authors： Chen Y,Liu S,Wan C,Zhang G

    更新日期：2021-01-01 00:00:00

  • Synthesis, structural characterization, QSAR and docking studies of a new binuclear nickel (II) complex based on the flexible tetradentate N-donor ligand as a potent antibacterial and anticancer agent.

    abstract：:A new nickel (II)complex namely [Ni2(Lt)Cl4] derived from the NiCl2.6H2O and 1,1,3,3-tetrakis(3,5-dimethyl-1-pyrazolyl)propane (Lt) has been synthesized and fully characterized by the single crystal X-ray diffraction, elemental analysis, FT-IR, UV-vis, density functional theory (DFT) calculations, antibacterial and an...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.06.098

    authors： Beheshti A,Hashemi F,Behavndi F,Zahedi M,Kolahi M,Motamedi H,Mayer P

    更新日期：2017-11-01 00:00:00

  • Development of behenic acid-ethyl cellulose oleogel stabilized Pickering emulsions as low calorie fat replacer.

    abstract：:This study investigated the optimization of thermal, functional and rheological properties of Ethyl Cellulose (EC)-based oleogel considering different concentrations of Behenic Acid (BA) and stability of water in oleogel (w/og) emulsions. The results showed that the combination of EC and BA improved the oleogel proper...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.10.205

    authors： Ahmadi P,Tabibiazar M,Roufegarinejad L,Babazadeh A

    更新日期：2020-05-01 00:00:00

  • Glucose-sensitive delivery of metronidazole by using a photo-crosslinked chitosan hydrogel film to inhibit Porphyromonas gingivalis proliferation.

    abstract：:A novel glucose-sensitive drug delivery system with controlled release of metronidazole was synthesized by using biocompatible photo-crosslinked chitosan hydrogel film. Specifically, methacrylic anhydride, as photosensitive substance, was firstly grafted on chitosan molecular chains and then UV irradiation was applied...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.09.202

    authors： Liu J,Xiao Y,Wang X,Huang L,Chen Y,Bao C

    更新日期：2019-02-01 00:00:00

  • Amylopectin-g-poly(methylacrylate-co-sodium acrylate): An efficient Cd(II) binder.

    abstract：:Synthesis, characterization and Cd(II) adsorption studies of a novel biodegradable graft copolymer based on partially hydrolysed polymethylacrylate (PMA) grafted amylopectin was reported, which was prepared by first grafting of PMA chains onto the amylopectin backbone followed by partial alkaline hydrolysis. The hydro...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.06.022

    authors： Sasmal D,Kolya H,Tripathy T

    更新日期：2016-10-01 00:00:00

  • WITHDRAWN: Long non-coding RNA H19 promotes angiogenesis in microvascular endothelial cells by down-regulating miR-181a.

    abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. ...

    journal_title：International journal of biological macromolecules

    pub_type： 撤回出版物

    doi：10.1016/j.ijbiomac.2018.08.091

    authors： Zhu A,Chu L,Ma Q,Li Y

    更新日期：2018-08-19 00:00:00

  • Molecular interactions in self-assembled nano-structures of chitosan-sodium alginate based polyelectrolyte complexes.

    abstract：:We report here the self-assembled structures of polyelectrolyte complexes (PECs) of polyanionic sodium alginate with the polycationic chitosan at room temperature. The PECs prepared at different pH values exhibited two distinct morphologies. The chitosan-alginate PECs self-assembled into the fibrous structure in a low...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.03.075

    authors： Wasupalli GK,Verma D

    更新日期：2018-07-15 00:00:00

  • Immobilization of tyrosinase and alcohol oxidase in conducting copolymers of thiophene functionalized poly(vinyl alcohol) with pyrrole.

    abstract：:Immobilization of tyrosinase and alcohol oxidase is achieved in the copolymer of pyrrole with vinyl alcohol with thiophene side groups (PVATh-co-PPy) which is a newly synthesized conducting polymer. PVATh-co-PPy/alcohol oxidase and PVATh-co-PPy/tyrosinase electrodes are constructed by the entrapment of enzyme in condu...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2007.04.006

    authors： Yildiz HB,Sahmetlioglu E,Boyukbayram AE,Toppare L,Yagci Y

    更新日期：2007-08-01 00:00:00

  • Isoenzyme-specific thermostability of human cytosolic creatine kinase.

    abstract：:Creatine kinase (CK) is a key enzyme involved in intracellular energy homeostasis. The distinct tissue distribution of muscle CK (MMCK) and brain CK (BBCK) implies that they function under conditions facing dissimilar environmental stresses. We found that MMCK and BBCK were significantly different in their stability a...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2010.03.025

    authors： Gao YS,Zhao TJ,Chen Z,Li C,Wang Y,Yan YB,Zhou HM

    更新日期：2010-07-01 00:00:00

  • Chitosan oligosaccharide-g-linalool polymer as inhibitor of hyaluronidase and collagenase activity.

    abstract：:In this study, chitosan oligosaccharide (COS) was modified by grafting Linalool (Lin) on its backbone to improve its anti-inflammatory activity. By changing the molar ratios of COS to Lin, three different degrees of substitution COS-g-Lin1-3 were prepared. The degrees of substitution of derivatives were 0.65, 0.80 and...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.11.036

    authors： Mao S,Liu X,Xia W

    更新日期：2021-01-01 00:00:00

  • Production and physicochemical characterization of bacterial poly gamma- (glutamic acid) to investigate its performance on enhanced oil recovery.

    abstract：:Bacillus licheniformis LMG 7559, which is capable of producing extracellular poly gamma- (glutamic acid) (PGA), was provided for the biopolymer synthesis. Using a modified PGA medium for PGA production, the isolated biopolymer, undergone dialysis process mainly for desalination and removal of other impurities. The bac...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.10.090

    authors： Azarhava H,Bajestani MI,Jafari A,Vakilchap F,Mousavi SM

    更新日期：2020-03-15 00:00:00

  • The effect of deep eutectic solvents on catalytic function and structure of bovine liver catalase.

    abstract：:Aqueous solutions of reline and glyceline, the most common deep eutectic solvents, were used as a medium for Catalase reaction. By some spectroscopic methods such as UV-vis, fluorescence and circular dichroism (CD) function and structure of Catalase were investigated in aqueous solutions of reline and glyceline. These...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.11.043

    authors： Harifi-Mood AR,Ghobadi R,Divsalar A

    更新日期：2017-02-01 00:00:00

  • Thermoplastic cassava starch/poly(lactic acid) blend reinforced with coir fibres.

    abstract：:One way to obtain more benefit from coconut waste is to utilise coir fibre (CF) as reinforcement in biodegradable plastics. The current work aims to study the effect of CF on the performance of a thermoplastic starch (TPS)/poly(lactic acid) (PLA) blend. TPS/PLA/CF biocomposites with a constant TPS: PLA ratio of 60:40 ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.121

    authors： Chotiprayon P,Chaisawad B,Yoksan R

    更新日期：2020-08-01 00:00:00

  • Fabrication of nanostructured mesoporous starch encapsulating soy-derived phytoestrogen (genistein) by well-tuned solvent exchange method.

    abstract：:The present research was concerned with preparation of mesoporous starch (MPS) as a carrier for genistein, a model of poorly water-soluble phytoestrogen isoflavone; and exploration of the impact of different fabrication parameters on structural and loading properties. MPS is considered as a highly porous biomaterial w...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.05.124

    authors： Soleimanpour M,Tamaddon AM,Kadivar M,Abolmaali SS,Shekarchizadeh H

    更新日期：2020-09-15 00:00:00

  • Preparation and evaluation of β-glucan hydrogel prepared by the radiation technique for drug carrier applications.

    abstract：:β-Glucan can provide excellent environment to apply to drug carrier due to its immunological and anti-inflammatory effect. Minocycline hydrochloride (MH) has excellent oral bioavailability pharmacological properties. Specifically, MH is effectively absorbed into the gingiva for periodontal disease treatment. In this s...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.06.068

    authors： Park JS,Lim YM,Baik J,Jeong JO,An SJ,Jeong SI,Gwon HJ,Khil MS

    更新日期：2018-10-15 00:00:00

  • Potential of Potentilla inclinata and its polyphenolic compounds in α-glucosidase inhibition: Kinetics and interaction mechanism merged with docking simulations.

    abstract：:In the present study we aimed to identify the α-glucosidase enzyme inhibitory potential of Potentilla inclinata Vill. MeOH and n-BuOH extracts which possessed remarkable α-glucosidase enzyme inhibitory effects with IC50 values of 1.06±0.02 and 0.93±0.01μg/ml respectively, compared to that of acarbose (IC50 31.92±0.17)...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.11.151

    authors： Şöhretoğlu D,Sari S,Šoral M,Barut B,Özel A,Liptaj T

    更新日期：2018-03-01 00:00:00

  • Biochemical, immunological and kinetic characterization and partial sequence analysis of a thiol proteinase inhibitor from Bubalus bubalis kidney: An attempt targeting kidney disorders.

    abstract：:In the present study a thiol proteinase inhibitor was isolated from buffalo kidney making use of ammonium sulphate precipitation and gel filtration chromatography on Sephacryl S-100HR column. Purified inhibitor is homogeneous as it displayed a single band in gel electrophoresis both under reducing and non-reducing env...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.12.084

    authors： Shamsi A,Ahmed A,Bano B

    更新日期：2017-01-01 00:00:00

  • Anti-glioma properties of DVL, a lectin purified from Dioclea violacea.

    abstract：:Plant lectins have been studied owing to their structural properties and biological effects that include agglutinating activity, antidepressant-like effect and antitumor property. The results from this work showed the effects of the lectin extracted from the Dioclea violacea plant (DVL) on the C6 rat glioma cell line....

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.08.106

    authors： Nascimento APM,Knaut JL,Rieger DK,Wolin IAV,Heinrich IA,Mann J,Juarez AV,Sosa LDV,De Paul AL,Moreira CG,Silva IB,Nobre CS,Osterne VJS,Nascimento KS,Cavada BS,Leal RB

    更新日期：2018-12-01 00:00:00

  • Amorphous aggregate adducts of linker histone H1 turn highly immunologic in the cancers of oesophagus, stomach, gall bladder and ovary.

    abstract：:Hyperglycaemic influence on carcinogenesis and tumour progression is emerging as a link between diabetes and cancer. This work establishes the disturbed structural integrity of nucleosomal linker histone H1 by methyglyoxal (MG) and then correlates the role of modified H1 in the auto-immunopathogenesis of multiple canc...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.12.060

    authors： Mir AR,Moinuddin,Habib S

    更新日期：2017-03-01 00:00:00

  • Circular dichroism of the non-enzymatic browning products of poly-L-lysine and albumin.

    abstract：:Poly-L-lysine (PLL) and bovine serum albumin were used as models in the investigation of non-enzymatic glycation and browning reaction by circular dichroism measurements. Different sugars (glucose, glucose-6-P and ribose) induced different extents of reaction and produced different chromophores that absorbed light in ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/0141-8130(90)90009-y

    authors： Liang JN

    更新日期：1990-08-01 00:00:00

  • Chemical characterization of polysaccharides isolated from scrophularia ningpoensis and its protective effect on the cerebral ischemia/reperfusin injury in rat model.

    abstract：:This study was designed to investigate the chemical characterization of scrophularia ningpoensis polysaccharides (SNP) and its protective activity on the cerebral ischemia/reperfusin injury (CIRI) rats. SNP was successfully isolated and fractionated by anion exchange chromatography and gel filtration into different fa...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.08.040

    authors： Ma S,Liu X,Cheng B,Jia Z,Hua H,Xin Y

    更新日期：2019-10-15 00:00:00

  • Characterization of intermediate state of myoglobin in the presence of PEG 10 under physiological conditions.

    abstract：:The macromolecular crowding progressively has been gaining prominence in recent years as it acts as a sword with double-edge on protein stability and folding, i.e., showing assorted results of having both stabilizing and destabilizing effects. We studied the effects of different concentrations of polyethylene glycol (...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.02.084

    authors： Parray ZA,Shahid S,Ahmad F,Hassan MI,Islam A

    更新日期：2017-06-01 00:00:00

  • Synthesis of gum kondagogu-g-poly(N-vinyl-2-pyrrolidone) and its evaluation as a mucoadhesive polymer.

    abstract：:The purpose of the present study was to synthesize gum kondagogu-g-poly(N-vinyl-2-pyrrolidone) and to evaluate its mucoadhesive properties. UV-assisted graft co-polymerization of N-vinyl-2-pyrrolidone on gum kondagogu was carried out employing three-factor, three-level central composite experimental designs. It was ob...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.07.009

    authors： Malik S,Kumar A,Ahuja M

    更新日期：2012-12-01 00:00:00

  • Effect of increased PHA synthase activity on polyhydroxyalkanoates biosynthesis in Synechocystis sp. PCC6803.

    abstract：:Polyhydroxyalkanoate (PHA) synthase activity in Synechocystis sp. PCC6803 was increased two-fold by introducing the PHA biosynthetic genes of Ralstonia eutropha. The resulting recombinant Synechocystis sp. PCC6803 strain was subjected to conditions that favor PHA accumulation and the effects of various carbon sources ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(02)00010-7

    authors： Sudesh K,Taguchi K,Doi Y

    更新日期：2002-04-08 00:00:00

  • Characterization of films based on chitosan lactate and its blends with oxidized starch and gelatin.

    abstract：:Minimal inhibitory concentration (MIC) of chitosan lactate (CHL) was tested against bacteria and phytopathogenic fungi. Then, the structural, physicochemical and antimicrobial properties of films based on CHL, oxidized potato starch (OPS), and gelatin (GEL) were investigated. With the exception of Rhizopus nigricans, ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.03.032

    authors： Kowalczyk D,Kordowska-Wiater M,Nowak J,Baraniak B

    更新日期：2015-01-01 00:00:00

  • Novel bio-inspired three-dimensional nanocomposites based on montmorillonite and chitosan.

    abstract：:In this study, inspired by nacre-like structural natural shells, novel three-dimensional (3D) nanocomposites based on natural nanoplatelets of montmorillonite (MMT) and polysaccharide of chitosan (CS) were prepared with solution intercalation and self-assembly process. The CS-intercalated-MMT nanoplatelets units acted...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.10.070

    authors： Zheng X,Xu M,Yang S,Omonov S,Huang S,Zhao J,Ruan H,Zeng M

    更新日期：2020-12-15 00:00:00

  • Expression and biochemical characterization of recombinant α-l-rhamnosidase r-Rha1 from Aspergillus niger JMU-TS528.

    abstract：:A putative cDNA of α-l-rhamnosidase was PCR-cloned from Aspergillus niger JMU-TS528 and further extracellular over-expressed in Pichia pastoris GS115. The activity of the recombinant α-l-rhamnosidase r-Rha1 was 711.9U/mL, eightfold higher than the native α-l-rhamnosidase from A. niger JMU-TS528. r-Rha1 is a N-glycosyl...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.12.093

    authors： Li L,Yu Y,Zhang X,Jiang Z,Zhu Y,Xiao A,Ni H,Chen F

    更新日期：2016-04-01 00:00:00

  • Effect of diameter of poly(lactic acid) fiber on the physical properties of poly(ɛ-caprolactone).

    abstract：:Biodegradable polymer composites based on poly(ɛ-caprolactone) (PCL) and poly(lactic acid) (PLA) fibers with diameters of 18, 26, 180 μm were prepared by melt compounding. The PLA fiber content in the composites was constant at 20% by weight. The effects of fibers with different diameters on the physical properties an...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.01.059

    authors： Ju D,Han L,Guo Z,Bian J,Li F,Chen S,Dong L

    更新日期：2015-05-01 00:00:00