当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Soy protein isolate supplemented silk fibroin nanofibers for skin tissue regeneration: Fabrication and characterization.

Soy protein isolate supplemented silk fibroin nanofibers for skin tissue regeneration: Fabrication and characterization.

Abstract：

:Biocompatible soy protein isolate/silk fibroin (SPI/SF) nanofibrous scaffolds were successfully fabricated through electrospinning a novel protein blend SPI/SF. Prepared nanofibers were treated with ethanol vapor to obtain an improved water-stable structure. Fabricated scaffolds were characterized through scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), UV-VIS spectrophotometry and image analysis. The mean diameters of SPI/SF electrospun fibers were observed ranging between 71 and 160 nm. The scaffolds were found significantly stable for a prolong duration at the room temperature as well as at 37 °C, when placed in phosphate buffered saline, nutrient medium, and lysozyme-containing solution. The potential of fabricated scaffolds for skin tissue regeneration was evaluated by in vitro culturing of standard cell lines i.e., fibroblast cells (L929-RFP (red fluorescent protein) and NIH-3T3) and melanocytes (B16F10). The outcomes revealed that all the fabricated nanofibrous scaffolds were non-toxic towards normal mammalian cells. In addition, healing of full-thickness wound in rats within 14 days after treatment with a nanofibrous scaffold demonstrated its suitability as a potential wound dressing material. Interestingly, we found that nanofibers induced a noticeable reduction in the proliferation rate of B16F10 melanoma cells.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Varshney N,Sahi AK,Poddar S,Mahto SK

doi

10.1016/j.ijbiomac.2020.05.090

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

112-127

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(20)33242-6

journal_volume

160

pub_type

杂志文章

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