TRIP13 is a predictor for poor prognosis and regulates cell proliferation, migration and invasion in prostate cancer.


:Thyroid hormone receptor interactor 13 (TRIP13) has been reported to be overexpressed in serval types of human cancers, and regulate tumor cell proliferation, migration and invasion. However, the role of TRIP13 in prostate cancer was still unclear. In our study, the correlation between TRIP13 expression and clinical parameters including prognosis was evaluated in 160 prostate cancer patients. Moreover, the MTT assay, cell migration and invasion assays were performed to assess the effect of TRIP13 on prostate cancer cell biological behaviour. In our results, the expression status of TRIP13 was observed to be elevated in prostate cancer tissue samples through analyzing microarray (GSE55945). Furthermore, mRNA and protein TRIP13 expression were confirmed to be overexpressed in prostate cancer tissue samples and cell lines. High-expression of TRIP13 was correlated with present lymph node involvement, distant metastasis, high Gleason score, levels of serum PSA and poor prognosis in prostate cancer patients. The gain-of-function and loss-of-function studies suggested that TRIP13 functioned as oncogene to regulate prostate cancer cell proliferation, migration, invasion through controlling YWHAZ and epithelial-mesenchymal transition (EMT)-associated genes. In conclusion, TRIP13 is correlated with clinical progression and poor prognosis, and serves as oncogene in prostate cancer.


Int J Biol Macromol


Dong L,Ding H,Li Y,Xue D,Li Z,Liu Y,Zhang T,Zhou J,Wang P




Has Abstract


2019-01-01 00:00:00












  • A comparative study of the suitability of different cereal straws for lignocellulose nanofibers isolation.

    abstract::The aim of this work is to study the suitability of different soda cereal straw pulps (wheat, barley, corn and oats) to produce lignocellulose nanofibers (LCNF). For the study of the influence of the composition and physical characteristics, the pulps were characterized, observing that the physical characteristics do ...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Espinosa E,Sánchez R,Otero R,Domínguez-Robles J,Rodríguez A

    更新日期:2017-10-01 00:00:00

  • The antitumor activity of a red alga polysaccharide complexes carrying 5-fluorouracil.

    abstract::Porphyran is a sulfated galactan isolated from red algae Porphyra haitanensis, and have been reported to have many kinds of biological activities such as antitumor activity. In order to provide a water-soluble macromolecule prodrug of 5-Fu showing slow release of 5-Fu and reducing side-effect, we carried out fixation ...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Wang X,Zhang Z

    更新日期:2014-08-01 00:00:00

  • Structural features and antioxidant activities of Chinese quince (Chaenomeles sinensis) fruits lignin during auto-catalyzed ethanol organosolv pretreatment.

    abstract::Chinese quince fruits (Chaenomeles sinensis) have an abundance of lignins with antioxidant activities. To facilitate the utilization of Chinese quince fruits, lignin was isolated from it by auto-catalyzed ethanol organosolv pretreatment. The effects of three processing conditions (temperature, time, and ethanol concen...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Cheng XC,Guo XR,Qin Z,Wang XD,Liu HM,Liu YL

    更新日期:2020-12-01 00:00:00

  • NMR and the mobility of water in polysaccharide gels.

    abstract::An analysis of the possible modes of motion of water molecules in polysaccharide gels indicates that the interpretation of NMR results does not require the supposition of a class of 'bound water' with highly perturbed motional states. There may, however, be water molecules associated with junction zones in the gels wh...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章,评审


    authors: Belton PS

    更新日期:1997-08-01 00:00:00

  • Organisation of the external region of the starch granule as determined by infrared spectroscopy.

    abstract::Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) was used to study the external regions of starch granules. Native starches (wheat, potato, maize, waxy maize and amylomaize) were analysed and compared to gelatinised and acid-hydrolysed starches. The IR spectra of potato and amylomaize starches were c...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Sevenou O,Hill SE,Farhat IA,Mitchell JR

    更新日期:2002-12-20 00:00:00

  • Purification, physicochemical properties, and statistical optimization of fibrinolytic enzymes especially from fermented foods: A comprehensive review.

    abstract::Fibrinolytic enzymes are proteases responsible for cleavage of fibrin mesh in thrombus clots, which are the primary causative agents in cardiovascular diseases. Developing safe, effective and cheap thrombolytic agents are important for prevention and cure of thrombosis. Although a wide variety of sources have been dis...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章,评审


    authors: Moula Ali AM,Bavisetty SCB

    更新日期:2020-11-15 00:00:00

  • Tailoring the surface properties and flexibility of starch-based films using oil and waxes recovered from potato chips byproducts.

    abstract::Agrofood byproducts may be exploited as a source of biomolecules suitable for developing bioplastic materials. In this work, the feasibility of using starch, oil, and waxes recovered from potato chips byproducts for films production was studied. The recovered potato starch-rich fraction (RPS) contained an amylopectin/...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Gonçalves I,Lopes J,Barra A,Hernández D,Nunes C,Kapusniak K,Kapusniak J,Evtyugin DV,Lopes da Silva JA,Ferreira P,Coimbra MA

    更新日期:2020-11-15 00:00:00

  • A review on processing techniques of bast fibers nanocellulose and its polylactic acid (PLA) nanocomposites.

    abstract::The utilization of nanocellulose has increasingly gained attentions from various research fields, especially the field of polymer nanocomposites owing to the growing environmental hazardous of petroleum based fiber products. Meanwhile, the searching of alternative cellulose sources from different plants has become the...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章,评审


    authors: Kian LK,Saba N,Jawaid M,Sultan MTH

    更新日期:2019-01-01 00:00:00

  • Temperature variation of the relaxation time of alpha-dispersion for gamma-irradiated collagen.

    abstract::The effect of gamma irradiation, with doses from 10(2) to 10(3) kGy, on the dielectric relaxation time of solid-state collagen was studied. Temperature measurements of the relaxation time were made over a range of frequency of the electric field from 10(1) to 10(5) Hz and at temperatures from 298 to 480 K. The samples...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Marzec E

    更新日期:1995-02-01 00:00:00

  • Improved thermal stability of polylactic acid (PLA) composite film via PLA-β-cyclodextrin-inclusion complex systems.

    abstract::The effects of the incorporation of PLA-β-cyclodextrin-inclusion complex (IC) and β-cyclodextrin (β-CD) on biopolyester PLA films were investigated. Thermal stability, surface morphology, barrier, and mechanical properties of the films were measured at varying IC (1, 3, 5, and 7%) and β-CD (1 and 5%) concentrations. T...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Byun Y,Rodriguez K,Han JH,Kim YT

    更新日期:2015-11-01 00:00:00

  • Biosynthesis of Ag nanoparticles using isolated bacteria from contaminated sites and its application as an efficient catalyst for hydrazine electrooxidation.

    abstract::In the present study, a bacterium resistance to heavy metals was isolated from contaminated areas. An eco-friendly and simple method was found to biosynthesis of silver nanoparticles (AgNPs) by reducing of aqueous Ag+ using the heavy metals resistance MKH1 bacterium. The biosynthesized AgNPs were characterized by UV-v...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Rostami H,Khosravi F,Mohseni M,Rostami AA

    更新日期:2018-02-01 00:00:00

  • Interaction of hexa-His tag with acidic amino acids results in facilitated refolding of halophilic nucleoside diphosphate kinase.

    abstract::We have previously reported that amino-terminal extension sequence containing hexa-His facilitated refolding and assembly of hexameric nucleoside diphosphate kinase from extremely halophilic archaeon Halobacterium salinarum (NDK). In this study, we made various mutations in both the tag sequence and within NDK molecul...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Ishibashi M,Ida K,Tatsuda S,Arakawa T,Tokunaga M

    更新日期:2011-11-01 00:00:00

  • Development and characterization of an LDPE/chitosan composite antimicrobial film for chilled fish storage.

    abstract::An antimicrobial packaging material was developed by uniformly embedding 1, 3 and 5% chitosan (w/w) in low density polyethylene matrix using maleic anhydride grafted LDPE as a compatible agent. The materials were mixed by compounding and blown into monolayer films via blown film extrusion. The developed films showed g...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Reesha KV,Panda SK,Bindu J,Varghese TO

    更新日期:2015-08-01 00:00:00

  • Potential of Potentilla inclinata and its polyphenolic compounds in α-glucosidase inhibition: Kinetics and interaction mechanism merged with docking simulations.

    abstract::In the present study we aimed to identify the α-glucosidase enzyme inhibitory potential of Potentilla inclinata Vill. MeOH and n-BuOH extracts which possessed remarkable α-glucosidase enzyme inhibitory effects with IC50 values of 1.06±0.02 and 0.93±0.01μg/ml respectively, compared to that of acarbose (IC50 31.92±0.17)...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Şöhretoğlu D,Sari S,Šoral M,Barut B,Özel A,Liptaj T

    更新日期:2018-03-01 00:00:00

  • Spectroscopic analysis of the interaction of valproic acid with histone H1 in solution and in chromatin structure.

    abstract::Histone H1 is a basic chromosomal protein which links adjacent nucleosomes in chromatin structure. Valproic acid (VPA), a histone deacetylase inhibitor, is widely used as an antiepileptic drug for the treatment of various cancers. In this study the interaction between VPA and histone H1, chromatin and DNA in solution ...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Sargolzaei J,Rabbani-Chadegani A,Mollaei H,Deezagi A

    更新日期:2017-06-01 00:00:00

  • A gellan gum derivative as in-situ gelling cationic polymer for nasal drug delivery.

    abstract::The aim of the present study was the development of a novel gellan gum derivative exhibiting mucoadhesive properties for nasal application. Accomplishing this, amino groups have been introduced to the polymeric backbone. The resulting synthesis products were characterized in terms of the amount of attached amino group...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Jelkmann M,Leichner C,Zaichik S,Laffleur F,Bernkop-Schnürch A

    更新日期:2020-05-04 00:00:00

  • Characterization and antioxidant activities of the polysaccharides from Radix Cyathulae officinalis Kuan.

    abstract::A water-soluble polysaccharide (PSRC) was extracted and purified from the roots of Radix Cyathulae officinalis Kuan, and its chemical characteristics, monosaccharide composition and antioxidant activities were characterized. The average of molecular weight (Mw) of PSRC was 182 kDa. The majority of monosaccharide compo...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Han X,Shen S,Liu T,Du X,Cao X,Feng H,Zeng X

    更新日期:2015-01-01 00:00:00

  • Thermo-sensitive chitosan copolymer-gold hybrid nanoparticles as a nanocarrier for delivery of erlotinib.

    abstract::Here, using (poly(N-isopropylacrylamide)-co-oleic acid)-g-chitosan ((PNIPAAm-co-OA)-g-CS), CS copolymer-gold hybrid nanoparticles (CGH NPs) were synthesized by autoreduction of auric cations (HAuCl4) in aqueous solution in the absence of any other reducing agent. The engineered thermo-sensitive CS copolymer with free ...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Fathi M,Sahandi Zangabad P,Barar J,Aghanejad A,Erfan-Niya H,Omidi Y

    更新日期:2018-01-01 00:00:00

  • Dibutyrylchitin nanoparticles as novel drug carrier.

    abstract::Chitin is a ubiquitous renewable biopolymer that is significantly distributed in the natural world. Biopolymeric nanoparticles (Nps) have been developed for various biomedical applications by researchers. Here, chitin derivative, dibutyrylchitin Nps (DBC) was synthesized as a nanocarrier for drug delivery using butyri...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Jain T,Kumar S,Dutta PK

    更新日期:2016-01-01 00:00:00

  • Topoisomerase inhibition and albumin interaction studies of acridine-thiosemicarbazone derivatives.

    abstract::In the present study, acridine-thiosemicarbazones (ATD) derivatives were tested for their interaction properties with BSA through UV-Vis absorption and fluorescence spectroscopic studies. Both hyperchromic and hypochromic effects, as well as red or blue shifts were demonstrated after the derivatives were added to the ...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: da Silva Filho FA,de Freitas Souza T,Ribeiro AG,Alves JEF,de Oliveira JF,de Lima Souza TRC,de Moura RO,do Carmo Alves de Lima M,de Carvalho Junior LB,de Almeida SMV

    更新日期:2019-10-01 00:00:00

  • Biochemical and structural characterization of Cryptosporidium parvum Lactate dehydrogenase.

    abstract::The protozoan parasite Cryptosporidium parvum causes waterborne diseases worldwide. There is no effective therapy for C. parvum infection. The parasite depends mainly on glycolysis for energy production. Lactate dehydrogenase is a major regulator of glycolysis. This paper describes the biochemical characterization of ...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Cook WJ,Senkovich O,Hernandez A,Speed H,Chattopadhyay D

    更新日期:2015-03-01 00:00:00

  • Morphological and thermal studies of chitin-curcumin blends derived polyurethanes.

    abstract::The present study describes a novel ecofriendly series of chitin/curcumin/1,4-butane diol (BDO) blend derived polyurethanes (PUs), using hydroxy terminated polybutadiene (HTPB) and hexamethylene diisocyanate (HDI) along with different mole ratio of chitin, curcumin and BDO. The structural and morphological elucidation...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Mahmood K,Zia KM,Zuber M,Tabasum S,Rehman S,Zia F,Noreen A

    更新日期:2017-12-01 00:00:00

  • Binding mechanism of kinase inhibitors to EGFR and T790M, L858R and L858R/T790M mutants through structural and energetic analysis.

    abstract::Experimental studies have demonstrated that L858R mutation in the EGF receptor (EGFR) confers tumor sensitivity whereas T790M and L858R/T790M mutations cause resistance to tyrosine kinase inhibitors in patients with non-small cell lung cancer. Theoretical studies have been carried out to try to clarify the structural ...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Bello M

    更新日期:2018-10-15 00:00:00

  • Distortions in protein helices.

    abstract::alpha-helices are the most common secondary structures in observed proteins. However, they are not always found in ideal helical conformation and they often exhibit structural distortions. Quantification of these irregularities become essential in understanding the packing of helices and therefore, their role in the f...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Geetha V

    更新日期:1996-08-01 00:00:00

  • Synthesis, antimicrobial and release of chloroamphenicol loaded poly(L-lactic acid)/ZrO2 nanofibrous membranes.

    abstract::Electrospinning technique was used to fabricate chloroamphenicol loaded poly (L-lactic acid)/ZrO2 (CP-PLLA/ZrO2) nanofibrous membranes. The average diameter of drug carrier PLLA/ZrO2 nanofibers increased with ZrO2 concentration increasing and ribbon-shape fibers were present when ZrO2 content reached 3% and above. The...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Wang H,Ma X,Li Y,Jiang S,Zhai L,Jiang S,Li X

    更新日期:2013-11-01 00:00:00

  • Effects of supplementation with L. plantarum TN8 encapsulated in alginate-chitosan in broiler chickens.

    abstract::This study was undertaken to investigate the effects of supplementation of probiotic strain Lactobacillus plantarum TN8 encapsulated in sodium alginate-chitosan or a commercial blend of essential oils on total cholesterol, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL) and growth performance of broiler ...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Trabelsi I,Ktari N,Ben Slima S,Bouchaala K,Ben Salah R

    更新日期:2016-08-01 00:00:00

  • A new water-soluble polysaccharide from Echinops pungens Trautv roots. Part I. Isolation, purification, characterization and antioxidant activity.

    abstract::EPPS, a new heteropolysaccharide from Echinops pungens roots, was extracted by warm water (70 °C) and fortuitously purified using column chromatographies on DEAE-cellulose A52 and Sephadex G-100. Total carbohydrate content, specific optical rotation and molecular mass of EPPS were 98.3%, -88.2 and 65.7 kDa, respective...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Hoseiniyan Benvidi SM,Jahanbin K

    更新日期:2020-10-15 00:00:00

  • Analysis of Aspergillus sp. lipase immobilization for the application in organic synthesis.

    abstract::Nowadays, for the industrial implementations, especially in the area of organic synthesis, immobilized enzymes are preferred over their soluble forms. Present study aimed to find fast, cost-efficient, and effective way of lipase immobilization for the use in organic media. Lipase from Aspergillus sp. (Resinase A 2X) w...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Gricajeva A,Kazlauskas S,Kalėdienė L,Bendikienė V

    更新日期:2018-03-01 00:00:00

  • Novel tacrine/acridine anticholinesterase inhibitors with piperazine and thiourea linkers.

    abstract::A new series of substituted tacrine/acridine and tacrine/tacrine dimers with aliphatic or alkylene-thiourea linkers was synthesized and the potential of these compounds as novel human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE) inhibitors with nanomolar inhibition activity was evaluated. The m...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Hamulakova S,Imrich J,Janovec L,Kristian P,Danihel I,Holas O,Pohanka M,Böhm S,Kozurkova M,Kuca K

    更新日期:2014-09-01 00:00:00

  • Development of a novel pH sensitive silane crosslinked injectable hydrogel for controlled release of neomycin sulfate.

    abstract::Silane crosslinked biopolymer based novel pH-responsive hydrogels were fabricated by blending the cationic (chitosan) and anionic (alginate) polymers with poly(vinyl alcohol). Tetraethoxysilane (TEOS) was used, as a crosslinker in different amounts due to its nonhazardous nature, to study its impact on physical and ch...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Jabeen S,Islam A,Ghaffar A,Gull N,Hameed A,Bashir A,Jamil T,Hussain T

    更新日期:2017-04-01 00:00:00