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UV-mediated synthesis of carboxymethyl cellulose/poly-N-isopropylacrylamide composite hydrogels with triple stimuli-responsive swelling performances.

Abstract：

:Carboxymethyl cellulose (CMC)/pPoly-N-isopropylacrylamide (PNIPAM) hydrogels were prepared using nanoclay as physical cross-linker by UV irradiation. PNIPAM/CMC hydrogels exhibit 3D network structures with high porosity. PNIPAM/CMC hydrogels exhibit not only high water absorption capacity, but also temperature, pH and salt mutiple-responsive swelling performance. Besides, they exhibit reversible swelling behavior in alternate de-ionized water and NaCl solution. Moreover, the fabricated PNIPAM/CMC hydrogels display great compression mechanical property. Then, tetracycline hydrochloride (TCH) was loaded into the PNIPAM/CMC hydrogels to endow their antibacterial ability. TCH loaded PNIPAM/CMC hydrogels exhibit excellent antibacterial activity against E. coli and B. subtilis and good biocompatibility. Thus, the PNIPAM/CMC composite hydrogels with triple stimuli-responsive swelling performances reported herein have great potentials in many biomedical applications.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Su C,Liu J,Yang Z,Jiang L,Liu X,Shao W

doi

10.1016/j.ijbiomac.2020.06.094

subject

Has Abstract

pub_date

2020-10-15 00:00:00

pages

1140-1148

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(20)33535-2

journal_volume

161

pub_type

杂志文章

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