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Protein phosphatase inhibitor-1 (PPI-1) has protective activities in stress conditions in E. coli.

Abstract：

:Protein phosphatase inhibitor-1 (PPI-1) is a major inhibitor of protein phosphatase 1 (PP1), which regulates signal transduction in many eukaryotic cellular processes. Biophysical studies have shown that PPI-1 has a large Stokes radius and is heat stable, suggesting that it lacks extensive secondary structures. The unfolded structure of PPI-1 may enable it to interact with many proteins or ligands during stress conditions. Here we show that PPI-1 can act as a protective molecule, inhibiting protein aggregation and guarding E. coli cells against various stresses. Therefore, PPI-1 seems to have a physiological function as a protective molecule as well as regulator of protein serine/threonine phosphatases.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Kim TD

doi

10.1016/j.ijbiomac.2006.01.001

keywords:

subject

Has Abstract

pub_date

2006-02-28 00:00:00

pages

70-6

issue

1

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(06)00013-4

journal_volume

38

pub_type

杂志文章

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