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Antioxidant, antibacterial and antitumoural activities of kraft lignin from hardwood fractionated by acid precipitation.

Abstract：

:Kraft lignin, so far useful for energy generation, has been gathering considerable attention as an alternative material to replace fossil-based resources mainly due to its high phenolic content. However, the wide molecular weight distribution and chemical composition heterogeneity led to the development of fractionation methods. Herein, to narrow such characteristics we used eucalypt kraft lignin fractionated at pH's 9, 7, 5 and 3 by sequential acid precipitation. These lignin fractions were first characterised by simultaneous pyrolysis and trimethylsilylation (SPyT) with N-Methyl-N-(trimethylsilyl) trifluoroacetamide with posterior tests of antioxidant, antibacterial, and antitumour activities. We observed higher ratio of syringyl/guaiacyl groups and increase in antioxidant activity in those fractions with lower molecular weight (precipitated at lower pH's). Fractions precipitated at pH's 9 and 7 have shown an outstanding antibacterial activity against five bacteria. Moreover, fractions 7 and 5 presented at cytotoxicity tests higher ability to inhibit the growth of U87MG and T98G glioma cells, while only a slight inhibition of adult human fibroblasts (non-tumour cells) was detected.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Lourençon TV,de Lima GG,Ribeiro CSP,Hansel FA,Maciel GM,da Silva K,Winnischofer SMB,de Muniz GIB,Magalhães WLE

doi

10.1016/j.ijbiomac.2020.11.033

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

1535-1542

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(20)34958-8

journal_volume

166

pub_type

杂志文章

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