Abstract:
:The aim of this study was to determine the antitumor and antiangiogenic effects of the Schisandra chinensis polysaccharides (SCP) in selected renal cell carcinoma (RCC) cells and evaluate its potential mechanism of action. In vitro, endothelial growth factor (VEGF) secretion by Caki-1 was blockaded in response to SCP treatment for 48h. In vivo, a significant tumor growth inhibition effect was observed after SCP administration for 4 weeks. Moreover, SCP treatment decreased the level of VEGF, CD31 and CD34 in RCC tumor tissues. Further analysis of the tumor inhibition mechanism indicated that the number of apoptotic tumor cells increased significantly; the expression of Bax and p53 increased; and the expression of Bcl-2 decreased dramatically in transplanted tumor tissues following SCP administration. These results indicated that the potential mechanisms involved by which SCP exerted its antitumor and antiangiogenic activity might be associated with the up-regulation of Bax and p53, downregulation of Bcl-2, as well as the reduction of VEGF, CD31 and CD34 in xenografted tumors. These findings demonstrated that the SCP is a potential antitumor agent for RCC treatment.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Qu HM,Liu SJ,Zhang CYdoi
10.1016/j.ijbiomac.2014.02.025subject
Has Abstractpub_date
2014-05-01 00:00:00pages
52-6eissn
0141-8130issn
1879-0003pii
S0141-8130(14)00109-3journal_volume
66pub_type
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journal_title:International journal of biological macromolecules
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journal_title:International journal of biological macromolecules
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journal_title:International journal of biological macromolecules
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journal_title:International journal of biological macromolecules
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更新日期:2018-07-01 00:00:00
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journal_title:International journal of biological macromolecules
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journal_title:International journal of biological macromolecules
pub_type: 杂志文章
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journal_title:International journal of biological macromolecules
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journal_title:International journal of biological macromolecules
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journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/s0141-8130(00)00158-6
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journal_title:International journal of biological macromolecules
pub_type: 杂志文章
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journal_title:International journal of biological macromolecules
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journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2013.06.024
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journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2015.06.031
更新日期:2015-09-01 00:00:00
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journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2017.03.173
更新日期:2017-08-01 00:00:00
abstract::Thebaine 6-O-demethylase (T6ODM) is an Fe(II)/2-oxoglutarate-dependent dioxygenase catalysing two oxidative O-demethylation reactions in morphine biosynthesis. Its crystal structure revealed a large active site pocket which is at least two times larger than necessary to accommodate a substrate (thebaine or oripavine) ...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2020.07.030
更新日期:2020-11-15 00:00:00
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journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2015.10.085
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journal_title:International journal of biological macromolecules
pub_type: 杂志文章,评审
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journal_title:International journal of biological macromolecules
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doi:10.1016/j.ijbiomac.2012.06.033
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journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2018.06.129
更新日期:2018-10-15 00:00:00
abstract::The cDNA of the β-1,4-endoxylanase of Aspergillus niger US368 was cloned and expressed in Pichia pastoris under the constitutive GAP promoter. The maximum activity obtained was 41 U mL(-1), which was about 3-fold higher than that obtained with the native species. The purified enzyme showed a specific activity of 910 U...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2015.04.053
更新日期:2015-08-01 00:00:00
abstract::In this present study, ternary nanocomposite films of chitosan/starch/halloysite nanotubes (ChSHT) were fabricated by solution casting process. The ternary nanocomposite films were characterized by using various techniques such as Fourier transform infrared (FTIR), X-ray Diffraction (XRD), water contact angle, water a...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2019.01.047
更新日期:2019-04-15 00:00:00
abstract::Debranching of (1, 6)-α-linkages in starch is of great significance as it is widely used in different industries. In recent years, identifying a single potential enzyme that could debranch (1, 6)-α-linkages and cleave (1, 4)-α-linkages brought great interest as amylopectin possessed both (1, 4)-α- and (1, 6)-α-linkage...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2017.03.129
更新日期:2017-08-01 00:00:00
abstract::α-Glucosidase is a critical associated enzyme with type 2 diabetes mellitus in humans. Inhibition of α-glucosidase is important due to the potential effect of down regulating glucose absorption in patients. In this study, the inhibitory activity of flavone luteolin on α-glucosidase and their interaction mechanism were...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2013.12.007
更新日期:2014-03-01 00:00:00
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journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2017.12.019
更新日期:2018-04-01 00:00:00
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journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2017.10.055
更新日期:2018-02-01 00:00:00
abstract::This paper introduces a cheap simple MWCNTs@paper biosensor for the detection of CA19-9, which is a biomarker of pancreatic cancer. By adding the CA19-9 antibody to the surface of MWCNTs which are deposited on the microporous filter paper, the correlation between the concentration of CA19-9 and resistance of biosensor...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2019.09.176
更新日期:2020-02-01 00:00:00
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journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2018.01.014
更新日期:2018-05-01 00:00:00
abstract::Wastewater contaminated with dyes is discharged by huge amount daily, and involved many hazardous materials. Thus, this study focused on introducing low cost, ecofriendly and available removal agent (lignin-based adsorbent). Three adsorbents, APKL-4, APKL-5 and APKL-6 were obtained using gradient acid precipitation te...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2020.12.206
更新日期:2020-12-31 00:00:00