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The interaction of amino acids, peptides, and proteins with DNA.

Abstract：

:Amino acids that carry charges on their side groups can bind to double stranded DNA (dsDNA) and change the strength of the double helix. Measurement of the DNA melting temperature (Tm) confirmed that acidic amino acids (Glu, Asp) weaken the H-bonds between DNA strands, whereas basic amino acids (Arg, Lys) strengthen the interaction between the strands. A rank correlation exists between the amino acid isoelectric points and the observed changes in Tm. A similar dependence of the hyperchromic effect on the isoelectric point of a protein (pepsin, insulin, cortexin, and protamine) was observed for DNA-protein complexes at room temperature. Short peptides (KE, AEDG, and KEDP) containing a mixture of acidic and basic amino acid residues also affect Tm and the stability of the double helix. A model for binding Glu and Lys to dsDNA was explored by a docking simulation. The model shows that Glu, in an untwisted shape, binds to dsDNA in its major groove and disrupts three H-bonds between the strands, thereby destabilizing the double helix. Lys, in an untwisted shape, binds to the external side of the dsDNA and forms two bonds with O atoms of neighboring phosphodiester groups, thereby strengthening the DNA helix.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Solovyev AY,Tarnovskaya SI,Chernova IA,Shataeva LK,Skorik YA

doi

10.1016/j.ijbiomac.2015.03.054

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

39-45

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(15)00206-8

journal_volume

78

pub_type

杂志文章

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