当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Polymer hydrogel from carboxymethyl guar gum and carbon nanotube for sustained trans-dermal release of diclofenac sodium.

Polymer hydrogel from carboxymethyl guar gum and carbon nanotube for sustained trans-dermal release of diclofenac sodium.

Abstract：

:Novel carboxymethyl guar gum (CMG)-chemically modified multiwalled carbon nanotube (MCNT) hybrid hydrogels were synthesized at different MCNT levels as potential device for sustained trans-dermal release of diclofenac sodium. Spectroscopy together with morphology, thermogravimetry, and rheological studies proved relatively strong CMG-MCNT interaction at 0.5 and 1 wt% levels of MCNT whereas de-wetting was increased with higher MCNT concentration. Drug encapsulation tendency increased with addition of MCNT; maximum entrapment was noticed at 1 wt% MCNT level. Hydrogels containing 0.5, 1 and 3 wt% MCNT exhibited slower trans-dermal release than neat CMG due to slightly higher gel viscosity and more drug entrapment. Slowest but steady release was obtained from 1 wt% MCNT loaded hydrogel due to highest viscous resistance among all other hybrid nanocomposites.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Giri A,Bhowmick M,Pal S,Bandyopadhyay A

doi

10.1016/j.ijbiomac.2011.08.003

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

885-93

issue

5

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(11)00303-5

journal_volume

49

pub_type

杂志文章

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