当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Both beta sheet breaker and alpha helix forming pentapeptide inhibits protein fibrillation: Implication for the treatment of amyloid disorders.

Both beta sheet breaker and alpha helix forming pentapeptide inhibits protein fibrillation: Implication for the treatment of amyloid disorders.

Abstract：

:For the first time, the effect of two novel designed pentapeptides on amyloid growth of human insulin using combined biophysical, microscopic, cell viability and computational approaches. Collective experimental data from ThT, ANS, and TEM demonstrate that in spite of having contrasting features, both peptides can effectively inhibit amyloid formation by prolonging lag phase, slowing down aggregation rate, and reducing final fibril formation (up to 84.26% and 85.24% by P1 and P7 respectively). Although pure amyloid caused profound cellular toxicity in SH-SY5Y neuronal cells, amyloid formed in the presence of peptides showed much reduced cellular toxicity. Such an inhibitory effect can be attributed to interference with the structural transition of insulin toward β-sheet structure by peptides. Furthermore, molecular dynamic simulations confirm that peptide preferentially binds to nearby region which is more prone to form aggregates that consequently disrupts self-assembly into amyloid fibrils (P1 and P7 possess inhibition constant value of 0.000183 and 0.000216 nm, respectively), supporting our experimental observations. This study underscores the information about the sequence based inhibition mechanism of peptides that might dictate their inhibition or modulation capacity, which might be helpful in designing anti-amyloid therapeutics.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Siddiqi MK,Majid N,Alam P,Malik S,Alam A,Rajan S,Ajmal MR,Khan RH

doi

10.1016/j.ijbiomac.2019.11.222

subject

Has Abstract

pub_date

2020-01-15 00:00:00

pages

102-111

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)37679-2

journal_volume

143

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Structural analysis of homologous repeated domains in alpha-actinin and spectrin.

    abstract：:The amino acid sequences of chick and slime mould alpha-actinin each contain four repeats of approximately 122 residues. These repeats are homologous to the 18-22 repeats, each of approximately 106 residues, found in the alpha and beta subunits of spectrin and fodrin, and to the multiple repeats of approximately 110 r...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/0141-8130(89)90047-0

    authors： Davison MD,Baron MD,Critchley DR,Wootton JC

    更新日期：1989-04-01 00:00:00

  • A new water-soluble polysaccharide from Echinops pungens Trautv roots. Part I. Isolation, purification, characterization and antioxidant activity.

    abstract：:EPPS, a new heteropolysaccharide from Echinops pungens roots, was extracted by warm water (70 °C) and fortuitously purified using column chromatographies on DEAE-cellulose A52 and Sephadex G-100. Total carbohydrate content, specific optical rotation and molecular mass of EPPS were 98.3%, -88.2 and 65.7 kDa, respective...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.06.128

    authors： Hoseiniyan Benvidi SM,Jahanbin K

    更新日期：2020-10-15 00:00:00

  • Characterization of solvent stable extracellular protease from Bacillus koreensis (BK-P21A).

    abstract：:A total of 18 protease producing bacterial strains were isolated from detergent effluent in South Korea using skim milk agar medium. A strain (BK-P21A) was selected and identified as Bacillus koreensis based on morphological, biochemical and molecular characterizations (16S rRNA gene sequence analysis). Optimized cult...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.02.014

    authors： Anbu P

    更新日期：2013-05-01 00:00:00

  • Modulation in quality attributes of dough and starch digestibility of unleavened flat bread on replacing wheat flour with different minor millet flours.

    abstract：:The dough characteristics and flat bread quality parameters were studied on replacing a part of wheat flour with different minor millets (finger, foxtail, barnyard, kodo, little, proso) in the proportion 3:1. The dietary fiber and phytic acid increased while damaged starch decreased on replacing wheat flour with mille...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.08.252

    authors： Sharma B,Gujral HS

    更新日期：2019-12-01 00:00:00

  • Biochemical and molecular characterization of a novel dye-decolourizing peroxidase from Raoultella ornithinolytica OKOH-1.

    abstract：:The increase in industrial demand for peroxidases has necessitated the search for novel peroxidase with excellent industrial versatility. Raoultella ornithinolytica OKOH-1 is a new ligninolytic bacteria with peroxidase production potential. However, there is paucity of information on characterization of peroxidase fro...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.10.045

    authors： Falade AO,Mabinya LV,Okoh AI,Nwodo UU

    更新日期：2019-01-01 00:00:00

  • Structure and anti-tumor activity of a polysaccharide from Bletilla ochracea Schltr.

    abstract：:The polysaccharide fraction of Bletilla ochracea (BOP) was isolated from its tubers, and purified by DEAE-52 Cellulose and Sephadex G-200 column chromatography. The structural features of BOP were analyzed by GC-MS, HPLP, FT-IR, methylation and NMR. The average molecular weight of BOP was approximately 4.9 × 105 Da, a...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.11.039

    authors： Niu J,Wang S,Wang B,Chen L,Zhao G,Liu S,Wang S,Wang Z

    更新日期：2020-07-01 00:00:00

  • Characterization and optimization of schizophyllan production from date syrup.

    abstract：:This study demonstrates the efficient utilization of low-cost agricultural substrates, particularly date syrup, by Schizophyllum commune ATCC 38548 for schizophyllan production. Initially, one factor-at-a-time method was used to find the best carbon and nitrogen sources for schizophyllan production. Subsequently, resp...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.07.059

    authors： Jamshidian H,Shojaosadati SA,Vilaplana F,Mousavi SM,Soudi MR

    更新日期：2016-11-01 00:00:00

  • A polysaccharide from Hedyotis diffusa interrupts metastatic potential of lung adenocarcinoma A549 cells by inhibiting EMT via EGFR/Akt/ERK signaling pathways.

    abstract：:In this study we investigated the potential effects of a polysaccharide (HDP) from Hedyotis diffusa on the metastasis in human lung adenocarcinoma A549 cells. HDP (25, 50 and 100μg/ml) significantly suppressed the cell adhesion, invasion and migration of A549 cells in a dose dependent manner by downregulation of matri...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.02.040

    authors： Lin L,Cheng K,He Z,Lin Q,Huang Y,Chen C,Xie Z,Chen L,Liang Z

    更新日期：2019-05-15 00:00:00

  • Enhanced B-phycoerythrin production by the red microalga Porphyridium marinum: A powerful agent in industrial applications.

    abstract：:The production of B-phycoerythrin (B-PE) from the red microalga Porphyridium marinum was optimized before to purify it and subsequently study its antioxidant activities. NaNO3, K2HPO4 and metal traces concentrations of the culture medium, and luminosity parameters were chosen, according to the Plackett-Burman design, ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.09.037

    authors： Gargouch N,Karkouch I,Elleuch J,Elkahoui S,Michaud P,Abdelkafi S,Laroche C,Fendri I

    更新日期：2018-12-01 00:00:00

  • Anti-tumor and anti-virus activity of polysaccharides extracted from Sipunculus nudus(SNP) on Hepg2.2.15.

    abstract：:Many polysaccharides have biological activities and have been investigated for their antitumor effects. In this study, we investigated the anti-tumor activity and anti-virus activity of SNP-the water-soluble polysaccharides extracted from Sipunculus nudus on Hepg2.2.15. Flow cytometry analysis demonstrated that SNP in...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.03.022

    authors： Su J,Jiang L,Wu J,Liu Z,Wu Y

    更新日期：2016-06-01 00:00:00

  • Chitosan-derived biochars obtained at low pyrolysis temperatures for potential application in electrochemical energy storage devices.

    abstract：:N-rich biochars were obtained via pyrolysis treatment of chitosan (a low-cost biopolymer from natural biomasses) at mild conditions (in the 284 °C-540 °C range), thus offering an energy efficient and low carbon footprint synthesis. These low surface area N-doped biochars were morphologically and physicochemically char...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.08.017

    authors： Nisticò R,Guerretta F,Benzi P,Magnacca G

    更新日期：2020-12-01 00:00:00

  • Controlled release of drug and better bioavailability using poly(lactic acid-co-glycolic acid) nanoparticles.

    abstract：:Tamoxifen (Tmx) embedded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PLGA-Tmx) is prepared to evaluate its better DNA cleavage potential, cytotoxicity using Dalton's lymphoma ascite (DLA) cells and MDA-MB231 breast cancer cells. PLGA-Tmx nanoparticles are prepared through emulsified nanoprecipitation technique...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.04.065

    authors： Pandey SK,Patel DK,Maurya AK,Thakur R,Mishra DP,Vinayak M,Haldar C,Maiti P

    更新日期：2016-08-01 00:00:00

  • Exploring the effects of methylene blue on amyloid fibrillogenesis of lysozyme.

    abstract：:The 129-residue lysozyme has been shown to form amyloid fibrils in vitro. While methylene blue (MB), a compound in the phenothiazinium family, has been shown to dissemble tau fibril formation, its anti-fibrillogenic effect has not been thoroughly characterized in other proteins/peptides. This study examines the effect...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.08.038

    authors： How SC,Cheng YH,Lo CH,Lai JT,Lin TH,Bednarikova Z,Antosova A,Gazova Z,Wu JW,Wang SS

    更新日期：2018-11-01 00:00:00

  • Susceptibilities of bacterial cellulose containing N-acetylglucosamine residues for cellulolytic and chitinolytic enzymes.

    abstract：:Detailed characterization of enzyme susceptibility of bacterial cellulose containing N-acetylglucosamine (GlcNAc) residues (N-AcGBC) which possess high susceptibility for cellulase and lysozyme and slight susceptibility for chitinase was studied. Turbidimetric lysozyme assay of N-AcGBC showed that (i) the susceptibili...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(05)80076-5

    authors： Ogawa R,Miura Y,Tokura S,Koriyama T

    更新日期：1992-12-01 00:00:00

  • Vigilin interacts with CTCF and is involved in the maintenance of imprinting of IGF2 through a novel RNA-mediated mechanism.

    abstract：:Accumulating evidence has revealed the imprinting of insulin-like growth factor-2 gene (IGF2) is maintained by binding of CCCTC binding factor (CTCF) to the unmethylated imprinting control region (ICR) between IGF2 and H19 genes. We have previously reported that high-density lipoprotein binding protein (HDLBP/vigilin)...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.11.109

    authors： Yu X,Liu Q,He J,Huang Y,Jiang L,Xie X,Liu J,Chen L,Wei L,Qin Y

    更新日期：2018-03-01 00:00:00

  • Chromium (VI) detoxification by oxidation and flocculation of exopolysaccharides from Arthrobacter sp. B4.

    abstract：:The exopolysaccharides from Arthrobacter sp. B4 (B4-EPS) exhibited an excellent chromium (VI) (Cr(VI)) removal capability without any pH adjustment, whereby 50mgL(-1) of Cr(VI) could be completely removed by 4gL(-1) of B4-EPS. The kinetics tests revealed that the first-order rate constant was 8.3×10(-5)s(-1) and the o...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.07.013

    authors： Li Y,Li Q,Fengying Y,Bao J,Hu Z,Zhu W,Zhao Y,Lin Z,Dong Q

    更新日期：2015-11-01 00:00:00

  • Synthesis and characterization of lactic acid esterified starch by an in-situ solid phase method.

    abstract：:To improve the hydrophobicity and thermoplastic processability of starch, lactic acid esterified starch (LA-e-starch) was prepared by in-situ solid phase esterification with corn starch as the raw material and LA as the esterifying agent. Fourier transform infrared spectroscopy confirmed that the esterification reacti...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.11.171

    authors： Li P,He X,Zuo Y,Li X,Wu Y

    更新日期：2020-08-01 00:00:00

  • Unravelling property of polysaccharides from Sargassum sp. as an anti-wrinkle and skin whitening property.

    abstract：:In recent years, the natural ingredients are in high demand in formulating the cosmetic products. Seaweed polysaccharides signify the attractive natural ingredient with a wide range of functional properties that are expected for cosmeceutical formulations. The present work aimed to study the skin protection ability of...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.08.027

    authors： Jesumani V,Du H,Pei P,Zheng C,Cheong KL,Huang N

    更新日期：2019-11-01 00:00:00

  • Synthesis of chitosan based molecularly imprinted polymer for pipette-tip solid phase extraction of Rhodamine B from chili powder samples.

    abstract：:The purpose work is devoted to design of a simple, one-pot and green approach for the synthesis of molecularly imprinted polymer to construct a selective sorbent for pipette-tip solid phase extraction of Rhodamine B from chili powder samples and its subsequence separation and quantification by high performance liquid ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.07.196

    authors： Bagheri AR,Ghaedi M

    更新日期：2019-10-15 00:00:00

  • Structure characterization of one polysaccharide from Lepidium meyenii Walp., and its antioxidant activity and protective effect against H2O2-induced injury RAW264.7 cells.

    abstract：:The structural characterization, antioxidant activity and protective effect against H2O2-induced injury RAW264.7 cells of a new polysaccharide (MP1) isolated from Lepidium meyenii Walp. were investigated. The molecular weight was estimated to be 4.67 × 105 Da by HPLC-ELSD analysis. Monosaccharide composition was deter...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.06.117

    authors： Wang W,Zhang F,Li Q,Chen H,Zhang W,Yu P,Zhao T,Mao G,Feng W,Yang L,Wu X

    更新日期：2018-10-15 00:00:00

  • C-terminal modification of monoclonal antibody drugs: amidated species as a general product-related substance.

    abstract：:Twelve therapeutic mAbs, comprising 10 IgG1s and 2 IgG4s, were analyzed by a peptide mapping technique to detect and quantify C-terminal modifications. C-terminal amidated structures were found in 8 out of the 12 mAbs. An in vitro study using a commercially available peptidylglycine alpha-amidating monooxygenase (PAM)...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.09.016

    authors： Tsubaki M,Terashima I,Kamata K,Koga A

    更新日期：2013-01-01 00:00:00

  • Comparative proteomics analysis of whitetop (Lepidium draba L.) seedlings in response to exogenous glucose.

    abstract：:In this research, a comparative proteomics approach was conducted to understand the physiological processes behind the sulforaphane formation in whitetop seedlings in response to exogenous glucose. Initially, 5-day-old whitetop seedlings were elicited by different concentrations (0, 166, 250, 277, 360 mM) of glucose f...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.09.016

    authors： Rezaee F,Lahouti M,Maleki M,Ganjeali A

    更新日期：2018-12-01 00:00:00

  • Artificial chaperones based on thermoresponsive polymers recognize the unfolded state of the protein.

    abstract：:Stabilization of the enzymes under stress conditions is of special interest for modern biochemistry, bioengineering, as well as for formulation and target delivery of protein-based drugs. Aiming to achieve an efficient stabilization at elevated temperature with no influence on the enzyme under normal conditions, we st...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.10.031

    authors： Semenyuk P,Tiainen T,Hietala S,Tenhu H,Aseyev V,Muronetz V

    更新日期：2019-01-01 00:00:00

  • Density functional theory studies of Pb (II) interaction with chitosan and its derivatives.

    abstract：:Density functional theory (DFT) studies of Pb (II) ions interaction with biopolymer chitosan and its derivatives are presented. Schiff bases and N-alkylated/arylated derivatives of chitosan were characterized as adsorbents of lead ions and are studied at monomer level. Natural bond orbital (NBO) analysis was carried o...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.01.006

    authors： Hassan B,Muraleedharan K,Abdul Mujeeb VM

    更新日期：2015-03-01 00:00:00

  • Purification and characterization of a heterodimeric mycelial lectin from Penicillium proteolyticum with potent mitogenic activity.

    abstract：:In the present study, Penicillium proteolyticum lectin was purified by DEAE-Sepharose chromatography followed by Sephadex G-100 gel filtration chromatography. A sequence of ion-exchange and gel filtration chromatography resulted in 52.30 fold purified lectin with a high yield of 84.21%. The purified P. proteolyticum l...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.01.103

    authors： Singh RS,Walia AK,Kennedy JF

    更新日期：2019-05-01 00:00:00

  • Transcriptome analysis of the effects of Hericium erinaceus polysaccharide on the lymphocyte homing in Muscovy duck reovirus-infected ducklings.

    abstract：:Hericium erinaceus polysaccharide (HEP) is a bioactive substance present in the fruiting bodies of H. erinaceus. Previously we have shown that HEP can repair the intestinal injury caused by Muscovy duck reovirus (MDRV) infection in Muscovy ducklings. To examine the effect of HEP on intestine mucosal MDRV immunity and ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.08.130

    authors： Liu Z,Li M,Yan P,Zhu Z,Liao L,Chen Q,Luo Y,Li H,Li J,Wang Q,Huang Y,Wu Y

    更新日期：2019-11-01 00:00:00

  • Design of a pH-sensitive magnetic composite hydrogel based on salecan graft copolymer and Fe3O4@SiO2 nanoparticles as drug carrier.

    abstract：:Salecan, a novel water-soluble extracellular β-glucan, is very suitable for the hydrogel preparation. Here, pH-sensitive magnetic composite hydrogel was fabricated by the graft copolymerization of crotonic acid (CA) and N-(hydroxymethyl) acrylamide (HMAA) onto salecan in the presence of Fe3O4@SiO2 nanoparticles for do...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.10.043

    authors： Hu X,Wang Y,Zhang L,Xu M,Zhang J,Dong W

    更新日期：2018-02-01 00:00:00

  • The preparation, characterization and in vitro application evaluation of soluble soybean polysaccharide films incorporated with cinnamon essential oil nanoemulsions.

    abstract：:In this study, we developed the new bioactive film from soluble soybean polysaccharide (SSPS) incorporated with different concentrations of cinnamon essential oil nanoemulsions (CNO) and the functional properties of them were evaluated. Then CNO-SSPS film was applied on the meat during refrigerate for 8 days. The use ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.01.145

    authors： Ghani S,Barzegar H,Noshad M,Hojjati M

    更新日期：2018-06-01 00:00:00

  • Organisation of the external region of the starch granule as determined by infrared spectroscopy.

    abstract：:Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) was used to study the external regions of starch granules. Native starches (wheat, potato, maize, waxy maize and amylomaize) were analysed and compared to gelatinised and acid-hydrolysed starches. The IR spectra of potato and amylomaize starches were c...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(02)00067-3

    authors： Sevenou O,Hill SE,Farhat IA,Mitchell JR

    更新日期：2002-12-20 00:00:00

  • Reviewing Mimosoideae lectins: A group of under explored legume lectins.

    abstract：:Lectins are proteins capable of specific and reversible binding to mono- and/or oligosaccharides, and within this group, Legume lectins are the most studied. However, most of these studies focus on the Papilionoideae subfamily, with Caesalpinioideae and Mimosoideae lectins being significantly less explored in the lite...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2020.03.113

    authors： Cavada BS,Osterne VJS,Oliveira MV,Pinto-Junior VR,Silva MTL,Bari AU,Lima LD,Lossio CF,Nascimento KS

    更新日期：2020-07-01 00:00:00