当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Identification and characterization of a polysaccharide from the roots of Morinda officinalis, as an inducer of bone formation by up-regulation of target gene expression.

Identification and characterization of a polysaccharide from the roots of Morinda officinalis, as an inducer of bone formation by up-regulation of target gene expression.

Abstract：

:Morinda officinalis is an important traditional tonic herbal medicine. In the present study, we found that crude polysaccharides extracted from M. officinalis, named MO90, could significantly increase the bone mineral density (BMD) of the whole femur, distal femur, and proximal femur in ovariectomized (OVX) rats. In addition, MO90 decreased the level of bone turnover markers and prevented the deterioration of trabecular microarchitecture. To investigate the fractions responsible for anti-osteoporosis activity, one novel inulin-type fructan, MOW90-1, was isolated from MOP90. Structural analysis indicated that MOW90-1 consists of a backbone of (2→1)-linked-β-D-Fruf, and is terminated with (1→)-linked-α-D-Glcp and (2→)-linked-β-D-Fruf. Furthermore, an in vitro anti-osteoporosis assay indicated that MOW90-1 promoted proliferation, differentiation, and mineralization of MC3T3-E1 cells by up-regulating the expression of runt-related transcription factor 2, osterix, osteopontin, and osteocalcin. In conclusion, our studies provide supporting evidence for future use of this novel M. officinalis fructan as a key nutrient of health products.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Yan C,Huang D,Shen X,Qin N,Jiang K,Zhang D,Zhang Q

doi

10.1016/j.ijbiomac.2019.04.084

subject

Has Abstract

pub_date

2019-07-15 00:00:00

pages

446-456

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)30768-8

journal_volume

133

pub_type

杂志文章

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