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Development and characterization of a novel GHR antibody antagonist, GF185.

Abstract：

:Here, we describe the development of a panel of monoclonal antibodies targeting the growth hormone receptor (GHR). Of these monoclonal antibodies (Mabs), GF185 was selected for further characterization due to its activities. Competitive receptor-binding assays and Western blotting analyses were used to demonstrate that GF185's epitopes are localized within subdomain 1 of the growth hormone receptor extracellular domain (GHR-ECD). Subsequently, we evaluated GF185's antagonistic activities in vivo and in vitro and showed that GF185 was able to neutralize growth hormone (GH) signalling and inhibit GH-induced Ba/F3-GHR proliferation. Our findings suggest that GF185 may serve as an attractive tool for GHR-related research and has a potential future application for the treatment of GH-dependent disease.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Sun F,Liu Y,Sun H,Tian B

doi

10.1016/j.ijbiomac.2015.05.039

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

864-70

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(15)00380-3

journal_volume

79

pub_type

杂志文章

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