当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Synthesis, characterization, and in vitro and in vivo 68Ga radiolabeling of thiosemicarbazone Schiff base derived from dialdehyde dextran as a promising blood pool imaging agent.

Synthesis, characterization, and in vitro and in vivo 68Ga radiolabeling of thiosemicarbazone Schiff base derived from dialdehyde dextran as a promising blood pool imaging agent.

Abstract：

:To be used as a carrier of 68Ga radioisotope for possible blood pool imaging studies, dialdehyde dextran thiosemicarbazone (DADTSC) Schiff base polymer with different thiosemicarbazone contents (TSCC) = 0.93, 2.43, and 3.4 mmol/g were synthesized and characterized by FT-IR, GPC, and CHNS. Although they were successfully radiolabeled at room temperature, stable radio-complexes were prepared at 60 °C. Effect of thiosemicarbazone content on the dissolution rate, cytotoxicity, coagulation and hemolysis activities, and radiolabeling efficiency of Schiff bases as well as on the in-vitro radio-complexes stability was investigated. DADTSC1 (TSCC = 0.93 mmol/g) showed a less cytotoxicity (cell viability, CV50 = 490 μg/ml), a better solubility, suitable coagulation and hemolytic activities, and a sufficient radiolabeling efficiency (Radiochemical purity (RCP) > 95%) and formed a stable (RCP > 90%) radio-complex, which be chosen for in-vivo biodistribution study in healthy rats through tissue sampling and counting for radioactivity. Like blood pool imaging agents, 68Ga-DADTSC1 presented a retention profile in blood circulation, though more studies, including imaging in larger mammals, are required.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Almasi T,Jabbari K,Gholipour N,Mokhtari Kheirabadi A,Beiki D,Shahrokhi P,Akhlaghi M

doi

10.1016/j.ijbiomac.2018.12.133

subject

Has Abstract

pub_date

2019-03-15 00:00:00

pages

915-921

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)33277-X

journal_volume

125

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Structure and properties of chitin/alginate blend membranes from NaOH/urea aqueous solution.

    abstract：:Chitin/alginate (CA) blend membranes were successfully prepared from 8 wt% NaOH/4 wt% urea aqueous solution by coagulating with 0.5M CaCl(2) aqueous solution containing 5 wt% HCl. Morphology, mechanical properties, thermal stability, and antimicrobial effects of the membranes were investigated by scanning electron mic...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.08.030

    authors： Li G,Li W,Deng H,Du Y

    更新日期：2012-12-01 00:00:00

  • Synthesis of antimicrobial Nisin-phosphorylated soybean protein isolate/poly(L-lactic acid)/ZrO2 membranes.

    abstract：:Electrospinning technique was used to fabricate the model drug Nisin loaded phosphorylated soybean protein isolate/poly(l-lactic acid)/zirconium dioxide (Nisin-PSPI/PLLA/ZrO2) nanofibrous membranes. The average diameter of drug carrier PSPI/PLLA/ZrO2 nanofibers increased with the increase of content PSPI and some spin...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.08.041

    authors： Jiang S,Wang H,Chu C,Ma X,Sun M,Jiang S

    更新日期：2015-01-01 00:00:00

  • Effect of sea buckthorn protein on the intestinal microbial community in streptozotocin-induced diabetic mice.

    abstract：:This study investigated the intestinal microbial community distribution of Type 2 diabetic mice and discussed the effects of the sea buckthorn protein on the regulation of gut microbes. Date was collected for 12 cases of normal mice (NC group), 12 cases of Type 2 diabetic mice (DC group), and 12 cases of highly concen...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.09.090

    authors： Yuan H,Shi F,Meng L,Wang W

    更新日期：2018-02-01 00:00:00

  • Understanding the adhesion mechanism of a mucin binding domain from Lactobacillus fermentum and its role in enteropathogen exclusion.

    abstract：:Lactobacillus species possesses surface exposed Mucin Binding Protein (MucBP) which plays a role in adhesion to gastrointestinal mucin. MucBP contains one or more mucin binding domain (MBD), the functionality of which has yet not been characterized thoroughly. Here, we have characterized a 93-amino acid MBD (MBD93) of...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.10.107

    authors： Chatterjee M,Pushkaran AC,Vasudevan AK,Menon KKN,Biswas R,Mohan CG

    更新日期：2018-04-15 00:00:00

  • Anti-inflammatory activity of polysaccharides from Phellinus linteus by regulating the NF-κB translocation in LPS-stimulated RAW264.7 macrophages.

    abstract：:Inflammatory response remains one of the most common and serious complications of disease. In order to profound understanding relationship between Phellinus linteus polysaccharides (TCM) and inflammation, inflammatory cell model was constructed by LPS acting RAW264.7 cell line. The results showed that TCM could decrea...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.02.023

    authors： Xie Z,Wang Y,Huang J,Qian N,Shen G,Chen L

    更新日期：2019-05-15 00:00:00

  • Extraction, purification and anti-osteoporotic activity of a polysaccharide from Epimedium brevicornum Maxim. in vitro.

    abstract：:Osteoporosis is the most widespread metabolic bone disease characterized by decreased bone mass and bone quality, and its diagnosis and treatment remains challenging. To date, medicinal plants have received increasing attention from researchers for researching effective and less toxic therapeutic ingredients, includin...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.11.145

    authors： Zheng H,He B,Wu T,Cai J,Wei J

    更新日期：2020-08-01 00:00:00

  • Synthesis of protocatechuic acid grafted chitosan copolymer: Structure characterization and in vitro neuroprotective potential.

    abstract：:Excessive free radicals can cause oxidative damage to human tissues, which results in a variety of diseases. Therefore, the development of antioxidant materials is one of the great projects in biomedical field. In this work, antioxidant protocatechuic acid (PCA) monomers were grafted onto chitosan (CS) backbones to de...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.12.019

    authors： Xu C,Guan S,Wang B,Wang S,Wang Y,Sun C,Ma X,Liu T

    更新日期：2018-04-01 00:00:00

  • Antitumor activity of polysaccharides from Lepista sordida against laryngocarcinoma in vitro and in vivo.

    abstract：:Four water-soluble polysaccharides (LSPa1, LSPb1, LSPb2 and LSPc1) extracted from the fruiting bodies of Lepista sordida were prepared by DEAE cellulose-52 anion-exchange and Sepharose 6 Fast Flow gel-permeation chromatography. LSPa1 was composed of Glc, Man and Gal with a molar ratio of 3.2: 1.3: 0.6. LSPb1, LSPb2 an...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.05.033

    authors： Miao S,Mao X,Pei R,Miao S,Xiang C,Lv Y,Yang X,Sun J,Jia S,Liu Y

    更新日期：2013-09-01 00:00:00

  • A comparative study of the suitability of different cereal straws for lignocellulose nanofibers isolation.

    abstract：:The aim of this work is to study the suitability of different soda cereal straw pulps (wheat, barley, corn and oats) to produce lignocellulose nanofibers (LCNF). For the study of the influence of the composition and physical characteristics, the pulps were characterized, observing that the physical characteristics do ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.05.156

    authors： Espinosa E,Sánchez R,Otero R,Domínguez-Robles J,Rodríguez A

    更新日期：2017-10-01 00:00:00

  • Characterization and application of a family B DNA polymerase from the hyperthermophilic and radioresistant euryarchaeon Thermococcus gammatolerans.

    abstract：:Thermococcus gammatolerans is anaerobic euryarchaeon which grows optimally at 88 °C and its genome encodes a family B DNA polymerase (Tga PolB). Herein, we cloned the gene of Tga PolB, expressed and purified the gene product, and characterized the enzyme biochemically. The recombinant Tga PolB can efficiently synthesi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.03.204

    authors： Zhang L,Jiang D,Shi H,Wu M,Gan Q,Yang Z,Oger P

    更新日期：2020-08-01 00:00:00

  • Effects of supplementation with L. plantarum TN8 encapsulated in alginate-chitosan in broiler chickens.

    abstract：:This study was undertaken to investigate the effects of supplementation of probiotic strain Lactobacillus plantarum TN8 encapsulated in sodium alginate-chitosan or a commercial blend of essential oils on total cholesterol, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL) and growth performance of broiler ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.05.044

    authors： Trabelsi I,Ktari N,Ben Slima S,Bouchaala K,Ben Salah R

    更新日期：2016-08-01 00:00:00

  • Oligo(lactic acid)-grafted starch: A compatibilizer for poly(lactic acid)/thermoplastic starch blend.

    abstract：:The objective of this study was to improve the compatibility between poly(lactic acid) (PLA) and thermoplastic starch (TPS) in PLA/TPS blown films by incorporating oligo(lactic acid)-grafted starch (OLA-g-starch) as a compatibilizer. OLA-g-starch with a degree of substitution of 1.2 and degree of polymerization of 2.0...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.05.178

    authors： Noivoil N,Yoksan R

    更新日期：2020-10-01 00:00:00

  • Purification, characterization and end product analysis of dextran degrading endodextranase from Bacillus licheniformis KIBGE-IB25.

    abstract：:Degradation of high molecular weight dextran for obtaining low molecular weight dextran is based on the hydrolysis using chemical and enzymatic methods. Current research study focused on production, purification and characterization of dextranase from a newly isolated strain of Bacillus licheniformis KIBGE-IB25. Dextr...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.04.007

    authors： Zohra RR,Aman A,Ansari A,Haider MS,Qader SA

    更新日期：2015-07-01 00:00:00

  • Xyloglucan-based hybrid nanocomposite with potential for biomedical applications.

    abstract：:Natural polymer-based hybrid nanocomposites have been proposed as one of the most promising tools for biomedical applications, including disease treatment and diagnosis procedures. Xyloglucan nanocapsules can simultaneously load magnetic iron oxide nanoparticles and bioactive for a specific tissue, reducing the proces...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.11.128

    authors： da Silva ACC,de Almeida RR,da Cruz Sousa AC,Martínez FNA,Denardin JC,de Morais SM,Ricardo NMPS

    更新日期：2021-01-31 00:00:00

  • Tyr320 is a molecular determinant of the catalytic activity of β-glucosidase from Neosartorya fischeri.

    abstract：:β-Glucosidases (BGL) are key members of the cellulase enzyme complex that determine efficiency of lignocellulosic biomass degradation, which have shown great functional importance to many biotechnological systems. A previous reported BGL from Neosartorya fischeri (NfBGL) showed much higher activity than other BGLs. Sc...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.02.117

    authors： Shanmugam R,Kim IW,Tiwari MK,Gao H,Mardina P,Das D,Kumar A,Jeya M,Kim SY,Kim YS,Lee JK

    更新日期：2020-05-15 00:00:00

  • M. leprae HSP18 suppresses copper (II) mediated ROS generation: Effect of redox stress on its structure and function.

    abstract：:Mycobacterium leprae, causative organism of leprosy, is known to counter redox stress generated by reactive oxygen species (ROS) during its survival inside host macrophages. But, the involvement of any antigenic protein(s) for countering such redox stress is still unknown. Interestingly, M. leprae HSP18, an important ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.12.215

    authors： Nandi SK,Chakraborty A,Panda AK,Biswas A

    更新日期：2020-03-01 00:00:00

  • Fabrication of cationic nanostructures from short self-assembling amphiphilic mixed α/β-pentapeptide: Potential candidates for drug delivery, gene delivery, and antimicrobial applications.

    abstract：:The present article describes designing and fabrication of nanostructures from a mixed α/β-pentapeptide, Lys-βAla-βAla-Lys-βAla, which majorly contains non-natural β-alanine residues in the backbone with two α-lysine residues at 1- and 4-positions. The amphiphilic pentapeptide showed the ability to self-assemble into ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.01.079

    authors： Goel R,Garg C,Gautam HK,Sharma AK,Kumar P,Gupta A

    更新日期：2018-05-01 00:00:00

  • Effect of cross-linking on the dimensional stability and biocompatibility of a tailored 3D-bioprinted gelatin scaffold.

    abstract：:Biocompatible and biodegradable gelatin is a good candidate bioink for use in 3D bioprinting technologies, but viscous gelatin solution has a low printability. In order to improve the poor printability of gelatin, we optimized the rheological properties of gelatin solution. 3D gelatin scaffolds were then cross-linked ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.05.207

    authors： Choi DJ,Kho Y,Park SJ,Kim YJ,Chung S,Kim CH

    更新日期：2019-08-15 00:00:00

  • Exploration of DNA binding mode, chemical nuclease, cytotoxic and apoptotic potentials of diketone based oxovanadium(IV) complexes.

    abstract：:Two diketone based oxovanadium complexes, viz., bis(4,4,4-trifluoro-1-phenylbutane-1,3-dionato)oxovanadium(IV) (1) and bis(1,1,1-trifluoropentane-2,4-dionato)oxovanadium(IV) (2), have been synthesized and characterized by spectroscopic and analytical techniques. The DNA binding and the cleaving ability of the complexe...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.02.027

    authors： Inamdar PR,Sheela A

    更新日期：2015-05-01 00:00:00

  • In-situ lignin drives lytic polysaccharide monooxygenases to enhance enzymatic saccharification.

    abstract：:Recently low-molecular lignin was reported to activate lytic polysaccharide monooxygenases (LPMOs) to oxidize cellulose. However, whether lignin formed in cell wall can play the role as electron donor for LPMOs is still largely unknown due to the complex ultrastructure of lignocellulosic biomass. In this study, we pre...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.06.014

    authors： Ni H,Li M,Li F,Wang L,Xie S,Zhang X,Yu H

    更新日期：2020-10-15 00:00:00

  • Internal structure of high degree substitution acetylated potato starch by chemical surface gelatinization.

    abstract：:To understand the contribution of granule inner portion to the pasting property of acetylated potato starch under the electric field and ultrasonic treatment, these starches were subjected to chemical surface gelatinization by 4.0 mol/L CaCl2 to obtain remaining granules with pasting time 0, 6, 12, 18, 24, 30 min, res...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.12.102

    authors： Cao M,Gao Q

    更新日期：2020-02-15 00:00:00

  • Thermo-sensitive chitosan based semi-IPN hydrogels for high loading and sustained release of anionic drugs.

    abstract：:Thermo-sensitive poly(N-isopropyl acrylamide-co-vinyl pyrrolidone)/chitosan [P(NIPAM-co-NVP)/CS] semi-IPN hydrogels with improved loading capacity and sustained release for anionic drugs NAP were prepared by free-radical polymerization. The LCST of hydrogels was adjusted to the vicinity of body temperature by introduc...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.02.013

    authors： Li G,Guo L,Chang X,Yang M

    更新日期：2012-05-01 00:00:00

  • Starch based biodegradable graft copolymer for the preparation of silver nanoparticles.

    abstract：:The synthesis and characterization of a novel biodegradable graft copolymer based on partially hydrolyzed polymethylacrylate (PMA) grafted amylopectin (AP) was reported which was developed for the synthesis of silver nanoparticles from silver nitrate solution by facile green technique. The prepared graft copolymer was...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.07.046

    authors： Das S,Sasmal D,Pal S,Kolya H,Pandey A,Tripathy T

    更新日期：2015-11-01 00:00:00

  • Common buckwheat-resistant starch as a suitable raw material for food production: A structural and physicochemical investigation.

    abstract：:Heat-moisture treatment (HMT) of starch is defined as a physical method to change its properties. Compared with maize and potato, starches from common buckwheat (Xinong9976 and Pingqiao2) were isolated and its morphology and physicochemical properties investigated by scanning electron microscope (SEM), X-ray diffracti...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.12.116

    authors： Gao L,Xia M,Li Z,Wang M,Wang P,Yang P,Gao X,Gao J

    更新日期：2020-02-15 00:00:00

  • The xylose-rich pectins from pea hulls.

    abstract：:The hot acid extract of pea hull, HSP, was rich in galacturonic acid, arabinose and xylose. It was fractionated by copper precipitation followed by ion-exchange chromatography. The copper-soluble fraction represented 26% of HSP and was mostly composed of an arabinan with a low degree of branching, some heteroxylans an...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(97)00055-x

    authors： Renard CM,Weightman RM,Thibault JF

    更新日期：1997-08-01 00:00:00

  • Interactions and compatibility of 11 S globulin from Vicia faba seeds and sodium salt of carboxymethylcellulose in an aqueous medium.

    abstract：:This work studies specific interactions and compatibility between a legumin and a linear carboxylated polysaccharide using gel permeation chromatography, sedimentation analysis, SDS gel electrophoresis, viscometry and phase analysis measurements. It uses the system water/11 S globulin/CMC as a model. Carboxymethylcell...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2005.12.011

    authors： Antonov YA,Dmitrochenko AP,Leontiev AL

    更新日期：2006-02-28 00:00:00

  • Structural characterization and neuroprotective effect of a polysaccharide from Corydalis yanhusuo.

    abstract：:In the present study, we investigated the neuroprotective effects of a purified Corydalis yanhusuo polysaccharide (CYP) on Aβ (25-35)-induced neurotoxicity and explored its underlying molecular mechanisms in PC12 cells. The results showed pretreatment with CYP (25, 50, and 100 μg/ml) prior to Aβ (25-35) exposure signi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.01.180

    authors： He Y,Xu W,Qin Y

    更新日期：2020-08-15 00:00:00

  • Characterization of an exopolysaccharide with distinct rheological properties from Paenibacillus edaphicus NUST16.

    abstract：:Microbial exopolysaccharides (EPSs) have been commercially used for decades owing to their distinct rheological properties. New EPSs with special traits are being explored continuously. The strain Paenibacillus edaphicus NUST16 was isolated in this study. NUST16 produces 12.5g/L EPS after 72h cultivation in shaker fla...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.06.030

    authors： Li J,Xu H,Chen X,Xu L,Cheng R,Zhang J,Wang S

    更新日期：2017-12-01 00:00:00

  • Molecular characterization, constitutive expression and GTP binding mechanism of Cirrhinus mrigala (Hamilton, 1822) Myxovirus resistance (Mx) protein.

    abstract：:Myxovirus resistance (Mx) proteins represents the subclass of the dynamin superfamily of large Guanosine triphosphates (GTPases), play esential role in intracellular vesicle trafficking, endocytosis, organelle homeostasis and mitochondria distribution. These proteins are key players of the vertebrate immune system, in...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.06.161

    authors： Roy P,Rout AK,Maharana J,Sahoo DR,Panda SP,Pal A,Nayak KK,Behera BK,Das BK

    更新日期：2019-09-01 00:00:00

  • Lysozyme-magnesium aluminum silicate microparticles: Molecular interaction, bioactivity and release studies.

    abstract：:The objectives of this study were to investigate the adsorption behavior of lysozyme (LSZ) onto magnesium aluminum silicate (MAS) at various pHs and to characterize the LSZ-MAS microparticles obtained from the molecular interaction between LSZ and MAS. The results showed that LSZ could be bound onto the MAS layers at ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.07.033

    authors： Kanjanakawinkul W,Medlicott NJ,Rades T,Puttipipatkhachorn S,Pongjanyakul T

    更新日期：2015-09-01 00:00:00