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Anti-inflammatory activity of polysaccharides from Phellinus linteus by regulating the NF-κB translocation in LPS-stimulated RAW264.7 macrophages.

Abstract：

:Inflammatory response remains one of the most common and serious complications of disease. In order to profound understanding relationship between Phellinus linteus polysaccharides (TCM) and inflammation, inflammatory cell model was constructed by LPS acting RAW264.7 cell line. The results showed that TCM could decrease the pro-inflammatory cytokines (TNF-α, IL-1β, IL-2, IL-6 and IL-12) contents and the mRNA expression levels and increase the anti-inflammatory cytokines (IL-4 and IL-10) contents and the mRNA expression levels. Additionally, the levels of NF-κB translocation was significantly decreased, which associated with the IκBα phosphorylation level decreased and the AMPKα phosphorylation level increased. These results indicated that TCM could reduce the inflammatory responses in the LPS induced inflammatory cell model might be related to inhibit NF-κB translocation and regulate the balance of anti-inflammatory and pro-inflammatory factors.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Xie Z,Wang Y,Huang J,Qian N,Shen G,Chen L

doi

10.1016/j.ijbiomac.2019.02.023

subject

Has Abstract

pub_date

2019-05-15 00:00:00

pages

61-67

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)36831-4

journal_volume

129

pub_type

杂志文章

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