当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Purification and neuroprotective effects of polysaccharides from Opuntia Milpa Alta in cultured cortical neurons.

Purification and neuroprotective effects of polysaccharides from Opuntia Milpa Alta in cultured cortical neurons.

Abstract：

:Opuntia is a traditional plant from China with medicinal applications. In this experiment, polysaccharides from Opuntia Milpa Alta (MAPs) were analyzed using gas chromatograph-mass spectrometer (GC-MS) method and result showed that MAPs contained mannose (6.37%), rhamnose (14.94%), xylose (1.99%), arabinose (24.07%), galactose (38.25%), ribose (2.63%) and glucose (11.48%). The neuroprotective effects of MAPs were evaluated at the mechanistic level in vitro models of cerebral ischemic injury. In vitro oxygen/glucose deprivation (OGD) model, MAPs (0.5 μg/ml, 5 μg/ml, 50 μg/ml) effectively increased cell viability by methyl thiazolyl tetrazolium (MTT) assay, inhibited cell cytotoxicity by lactate dehydrogenase (LDH) assay, reduced neuronal cell death, suppressed the production of intracellular reactive oxygen species (ROS), decreased of intracellular free Ca(2+) concentrations ([Ca(2+)](i)), and reduced extracellular glutamate level. Therefore, MAPs might prevent intracellular calcium overload and decreased glutamate excitotoxicity, both of which can cause neuronal injury and death in vitro models of cerebral ischemic injury.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Chen Y,Zhao B,Huang X,Zhan J,Zhao Y,Zhou M,Guo L

doi

10.1016/j.ijbiomac.2011.06.031

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

681-7

issue

4

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(11)00278-9

journal_volume

49

pub_type

杂志文章

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