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Structural characterization and neuroprotective effect of a polysaccharide from Corydalis yanhusuo.

Abstract：

:In the present study, we investigated the neuroprotective effects of a purified Corydalis yanhusuo polysaccharide (CYP) on Aβ (25-35)-induced neurotoxicity and explored its underlying molecular mechanisms in PC12 cells. The results showed pretreatment with CYP (25, 50, and 100 μg/ml) prior to Aβ (25-35) exposure significantly protected PC12 cells from Aβ (25-35)-induced cell death, lactate dehydrogenase (LDH) release, DNA fragmentation, mitochondrial dysfunction and mitochondrial cytochrome c release. Moreover, Aβ (25-35)-induced increase of ratio between Bax and Bcl-2 protein expression was dramatically reversed by CYP pretreatment. Furthermore, the addition of CYP led to a significant repressing effect on the elevated protein expression of cleaved caspase-8, caspase-9, and caspase-3 in Aβ (25-35)-treated PC12 cells. Taken together, these findings indicated that protective effect of CYP against Aβ (25-35)-induced toxicity in PC12 cells was probably mediated by inhibition of apoptosis via both mitochondrial apoptotic pathway and death receptor pathway.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

He Y,Xu W,Qin Y

doi

10.1016/j.ijbiomac.2020.01.180

subject

Has Abstract

pub_date

2020-08-15 00:00:00

pages

759-768

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)38740-9

journal_volume

157

pub_type

杂志文章

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